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公开(公告)号：WO2017151909A3
公开(公告)日：2017-09-08
申请号：PCT/US2017/020437
申请日：2017-03-02
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： MCLEAN, Will
Abstract: Provided are compositions and methods for using Wnt agonist, GSK3-alpha inhibitor, or GSK3-beta inhibitors in combination with TGF-beta inhibitors to induce the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining in the daughter cells the capacity to differentiate into hair cells.
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公开(公告)号：WO2020081838A1
公开(公告)日：2020-04-23
申请号：PCT/US2019/056771
申请日：2019-10-17
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： LOOSE, Christopher , TAIT, Bradley , MANCHANDA, Rajesh , MCLEAN, Will , HARRISON, Megan , STRECKER, Sara
Abstract: The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
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公开(公告)号：WO2020037323A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/047106
申请日：2019-08-19
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： LOOSE, Christopher , MCLEAN, Will , HARRISON, Megan
IPC: C12N5/0793 , A61P27/16 , A61K9/00 , A61K31/19 , A61K47/00
Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
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4.发明申请METHODS FOR CONTROLLED PROLIFERATION OF VESTIBULAR STEM CELLS / GENERATING INNER EAR HAIR CELLS USING WNT AND TGF-BETA INHIBITION 审中-公开用WNT和TGF-β抑制剂刺激前庭干细胞/内耳发细胞增殖的方法
公开(公告)号：WO2017151909A2
公开(公告)日：2017-09-08
申请号：PCT/US2017/020437
申请日：2017-03-02
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： MCLEAN, Will
Abstract: Provided are compositions and methods for using Wnt agonist, GSK3-alpha inhibitor, or GSK3-beta inhibitors in combination with TGF-beta inhibitors to induce the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining in the daughter cells the capacity to differentiate into hair cells.
Abstract translation: 提供了使用Wnt激动剂，GSK3-α抑制剂或GSK3-β抑制剂与TGF-β抑制剂组合以诱导干/祖细胞支持细胞的自我更新的组合物和方法，包括诱导 干/祖细胞增殖，同时维持子细胞分化成毛细胞的能力。
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公开(公告)号：WO2023081923A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/079480
申请日：2022-11-08
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： MAGAVI, Sanjay Shivayogi , PARKS, Daniel J. , TAIT, Bradley Dean , CHO, Jinhyung , AGRAWAL, Rajiv , SHAW, Patricia R.
IPC: C07D487/04 , C07D471/04 , A61P25/00 , A61P25/28 , A61P27/00 , A61K31/437
Abstract: The present disclosure provides compounds that can specifically target a PDGFRα, and thereby, reduce and/or inhibit the activation of the receptor ("PDGFRα inhibitor"). The present disclosure also provides methods of treating a demyelinating disease using the disclosed PDGFRα inhibitors.
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Patent Agency Ranking
公开(公告)号：WO2020163813A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/017353
申请日：2020-02-07
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： MCLEAN, Will , HARRISON, Megan , TAIT, Bradley
IPC: A61K9/00 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P27/16 , A61P43/00 , A61K31/19 , A61K31/4164 , A61K31/4178 , A61K31/4402
Abstract: Provided are compositions and methods comprising a TAZ activator and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
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公开(公告)号：WO2020037325A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/047109
申请日：2019-08-19
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： LOOSE, Christopher , MCLEAN, Will , HARRISON, Megan
IPC: C12N5/0793 , A61P27/16 , A61K9/00 , A61K31/19
Abstract: Provided are compositions and methods comprising PI3K agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
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公开(公告)号：WO2020163816A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/017356
申请日：2020-02-07
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： TAIT, Bradley , HARRISON, Megan , MCLEAN, Will
IPC: C07D217/26 , A61P27/16 , A61K31/473
Abstract: The present disclosure relates to quinolin-4-one and 4(1 H )-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
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公开(公告)号：WO2020072602A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/054236
申请日：2019-10-02
Applicant: FREQUENCY THERAPEUTICS, INC. , MCLEAN, Will
Inventor： MCLEAN, Will , MANCHANDA, Rajesh , KHEDKAR, Snehal , STRONG, JR., Richard A. , BANKS, Ashley , TAIT, Bradley , LOOSE, Christopher
Abstract: The present disclosure relates to pharmaceutical compositions (e.g., pre-lyophilized pharmaceutical compositions, lyophilized pharmaceutical compositions, and reconstituted solutions) comprising one or more otic therapeutic agents. The present disclosure also relates to methods of preparing the pharmaceutical compositions, and methods of using the pharmaceutical compositions for therapeutic purpose.
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公开(公告)号：WO2020037326A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/047110
申请日：2019-08-19
Applicant: FREQUENCY THERAPEUTICS, INC.
Inventor： LOOSE, Christopher , MCLEAN, Will , HARRISON, Megan , HILL-DRZEWI, Melissa
IPC: C12N5/0793 , A61P27/16 , A61K9/00 , A61K31/19 , A61K47/00
Abstract: Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
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