公开(公告)号：WO2023081840A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/079324

申请日：2022-11-04

Applicant: FRONTIER MEDICINES CORPORATION

Inventor： PATEL, Snahel ,  TANAKA, Hiroko ,  ERLANSON, Daniel A. ,  GERKEN, Philip A. ,  WIDEN, John C. ,  WILLIAMS, Monika Jane ,  DOTSENKO, Irina

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The present disclosure provides compounds and methods useful in the treatment and suppression of cancer, for example, useful for treating or suppressing cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

公开(公告)号：WO2023015237A1

公开(公告)日：2023-02-09

申请号：PCT/US2022/074512

申请日：2022-08-04

Applicant: FRONTIER MEDICINES CORPORATION

Inventor： ERLANSON, Daniel A. ,  WEBSTER, Kevin Richard

IPC: G01N33/68 ,  A61K47/55

Abstract: The present disclosure relates generally to biological entity-protein (e.g. protein-protein) interactions for potential therapeutic applications, and more specifically to high- throughput methods for identifying bridging molecules that induce the formation of recruited biological entity-bridging molecule-target protein complexes to effect said biological entity-protein interactions. The present disclosure also provides methods for using said bridging molecules for treatment of disorders mediated by the target protein of the recruited biological entity-molecule-target protein complex.

公开(公告)号：WO2022026726A1

公开(公告)日：2022-02-03

申请号：PCT/US2021/043724

申请日：2021-07-29

Applicant: FRONTIER MEDICINES CORPORATION

Inventor： DE OLIVEIRA, Saulo ,  HERMANN, Johannes ,  VARMA, Chris

IPC: G16B40/00 ,  C12Q1/37

Abstract: Techniques for characterizing protein candidate sites are provided. Experimental data comprising spectral data from an experimental data source is received. Based on the experimental data, a data set comprising a set of protein candidate sites within one or more proteins is created. For each protein candidate site of the set of protein candidate sites, a feature set characterizing the respective protein candidate site is generated. A characterization of the amenability for drug-discovery for one or more of the protein candidate sites is generated by applying a classifier to the respective feature set for the protein candidate site.

公开(公告)号：WO2021061858A1

公开(公告)日：2021-04-01

申请号：PCT/US2020/052322

申请日：2020-09-23

Applicant: FRONTIER MEDICINES CORPORATION

Inventor： SHAGHAFI, Michael B. ,  HERMANN, Johannes

IPC: C07K16/18 ,  C07K16/30 ,  C12Q1/6886

Abstract: Provided herein are methods and compounds for targeted autophagy.

公开(公告)号：WO2022026723A2

公开(公告)日：2022-02-03

申请号：PCT/US2021/043721

申请日：2021-07-29

Applicant: FRONTIER MEDICINES CORPORATION

Inventor： DE OLIVEIRA, Saulo ,  HERMANN, Johannes ,  VARMA, Chris

IPC: G16B40/00 ,  G01N2500/04 ,  G16B15/30 ,  G16B45/00 ,  G16B50/30

Abstract: Techniques for characterizing protein candidate sites are provided. Experimental data comprising spectral data from an experimental data source is received. Based on the experimental data, a data set comprising a set of protein candidate sites within one or more proteins is created. For each protein candidate site of the set of protein candidate sites, a feature set characterizing the respective protein candidate site is generated. A characterization of the amenability for drug-discovery for one or more of the protein candidate sites is generated by applying a classifier to the respective feature set for the protein candidate site.

公开(公告)号：WO2019183600A1

公开(公告)日：2019-09-26

申请号：PCT/US2019/023753

申请日：2019-03-22

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FRONTIER MEDICINES CORPORATION

Inventor： NOMURA, Daniel, K. ,  ZONCU, Roberto ,  WARD, Carl ,  FUNG, Sin, Ki ,  VARMA, Chris, Kumar ,  FONTAINE, Benjamin

IPC: C07K16/18 ,  C07K16/30 ,  C12Q1/6886

Abstract: Provided herein, inter alia , are methods and compounds for targeted autophagy.