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公开(公告)号：WO2013036684A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054022
申请日：2012-09-06
Applicant: SATORI PHARMACEUTICALS, INC , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
IPC: A01N43/38
CPC classification number: C07D491/052 , C07D311/78 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12 , C07D495/04 , C07J53/002 , C07J71/0005 , C07J71/0052 , C07J71/0057 , C07J71/0068
Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein each of the variables listed above are as defined and described herein, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中上述各变量如本文所定义和描述，其组合物及其使用方法。
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公开(公告)号：WO2013036679A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054013
申请日：2012-09-06
Applicant: SATORI PHARMACEUTICALS, INC. , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
CPC classification number: C07J71/0005
Abstract: The present invention provides compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R x is as defined and described herein, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供式（I）化合物或其药学上可接受的盐，其中Rx如本文所定义和描述，其组合物及其使用方法。
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公开(公告)号：WO2013036678A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054011
申请日：2012-09-06
Applicant: SATORI PHARMACEUTICALS, INC. , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
IPC: C07D311/78 , C07D311/94
CPC classification number: C07J71/0005
Abstract: The present invention provides compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 is as defined and described herein, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供式（I）化合物或其药学上可接受的盐，其中R 1如本文所定义和描述，其组合物及其使用方法。
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公开(公告)号：WO2013036674A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054007
申请日：2012-09-06
Applicant: SATORI PHARMACEUTICALS, INC. , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBB, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBB, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
IPC: A61K31/58 , C07J71/00 , C07C271/06
CPC classification number: C07J71/0005
Abstract: The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 and R 5 are as defined and described herein, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供式（I）化合物或其药学上可接受的盐，其中R 1和R 5如本文所定义和描述，其组合，及其使用方法。
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5.发明申请COMPOUNDS FOR USE IN TREATING NEURODEGENERATIVE DISORDERS, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO 审中-公开用于治疗神经损伤性疾病的化合物，其合成及其中间体
公开(公告)号：WO2013036665A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053997
申请日：2012-09-06
Applicant: SATORI PHARMACEUTICALS, INC. , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , SHEN, Ruichao
IPC: A61K31/58
CPC classification number: C07J71/0005
Abstract: The present invention provides methods for preparing compounds useful as modulators of amyloid-beta production. Such compounds are useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides intermediates useful in carrying out such synthetic methods. Compounds of this invention are further illustrated by the embodiments, sub-embodiments, and species disclosed herein.
Abstract translation: 本发明提供了制备可用作淀粉样蛋白-β生产调节剂的化合物的方法。 这样的化合物可用于治疗或减轻神经变性疾病的严重性。 本发明还提供了可用于进行这种合成方法的中间体。 本发明的化合物通过本文公开的实施方案，亚实施方案和物质进一步说明。
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Patent Agency Ranking
公开(公告)号：WO2011109657A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/027084
申请日：2011-03-03
Applicant: SATORI PHARMACEUTICALS, INC. , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FINDEIS, Mark, Arthur , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FINDEIS, Mark, Arthur , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
CPC classification number: C07J71/0005 , C07J71/0057
Abstract: As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
Abstract translation: 如本文所述，本发明提供了可用于治疗或减轻神经变性疾病严重程度的化合物。 本发明还提供了治疗或减轻此类疾病严重程度的方法，其中所述方法包括向患者施用本发明化合物或其组合物。 所述方法可用于治疗或减轻例如阿尔茨海默病的严重性。
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公开(公告)号：WO2014106102A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/078078
申请日：2013-12-27
Applicant: SMITH INTERNATIONAL, INC. , SCHLUMBERGER CANADA LIMITED , SERVICES PETROLIERS SCHLUMBERGER , SCHLUMBERGER HOLDINGS LIMITED , SCHLUMBERGER TECHNOLOGY B.V. , PRAD RESEARCH AND DEVELOPMENT LIMITED , MAHAJAN, Manoj, D. , BRIETZKE, Daniel, W. , FULLER, Nathan , BARNHOUSE, James , ISHAK, Georges
Inventor： MAHAJAN, Manoj, D. , BRIETZKE, Daniel, W. , FULLER, Nathan , BARNHOUSE, James , ISHAK, Georges
CPC classification number: E21B10/322 , E21B10/325
Abstract: An underreamer for increasing the diameter of a bore. The underreamer includes a substantially cylindrical body having an axial bore therein. A mandrel may extend axially through the axial bore. One or more cutter blocks are movably coupled to the body. A ratio of a height of the cutter block to a diameter of the body is between about 0.35:1 and about 0.50:1.
Abstract translation: 用于增加孔直径的扩孔器。 该扩孔器包括其中具有轴向孔的基本上圆柱形的主体。 心轴可以轴向延伸穿过轴向孔。 一个或多个切割块可移动地联接到主体。 切割块的高度与主体的直径的比率在约0.35:1和约0.50:1之间。
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8.发明申请APPARATUS AND METHOD FOR PROPORTIONALLY CONTROLLING FLUID DELIVERY TO STACKED MOLDS 审中-公开用于比例控制流体输送到堆叠模型的装置和方法
公开(公告)号：WO2002074516A1
公开(公告)日：2002-09-26
申请号：PCT/US2002/008364
申请日：2002-03-19
Applicant: SYNVENTIVE MOLDING SOLUTIONS, INC. , FULLER, Nathan , MOSS, Mark , KAZMER, David , GALATI, Vito
Inventor： FULLER, Nathan , MOSS, Mark , KAZMER, David , GALATI, Vito
IPC: B29C45/23
CPC classification number: B29C45/2704 , B29C45/27 , B29C45/2806 , B29C45/322 , B29C45/76 , B29C2045/2687 , B29C2045/2722 , B29C2045/2761 , B29C2045/2882 , B29C2045/2886
Abstract: An injection molding machine (1000) having first and second nozzles (1093, 1095) for delivering melt material to first and second mold cavities (1308, 1328) of first and second molds (1010, 1020) respectively, apparatus for controlling delivery of the melt material from the nozzles to the mold cavities, each nozzle having an exit aperture communicating with a gate of a cavity of a respective mold and being associated with an actuator (1300, 1320) interconnected to a melt flow controller, the apparatus comprising a sensor (1304, 1306, 1324, 1326) for sensing a selected condition of the melt material through at least one of the nozzles; an actuator controller interconnected to each actuator, the actuator controller interconnected to the actuator associated with the at least one nozzle comprising a computer interconnected to the sensor, the computer receiving a signal representative of the selected condition sensed by the sensor, the computer including an algorithm utilizing a value corresponding to a signal received from the sensor.
Abstract translation: 一种注塑机（1000），其具有用于将熔体材料分别输送到第一和第二模具（1010,1020）的第一和第二模腔（1308,1328）的第一和第二喷嘴（1093,1095），用于控制 将材料从喷嘴熔化到模具腔，每个喷嘴具有与相应模具的空腔的浇口连通并与互连到熔体流动控制器的致动器（1300,1320）相关联的出口孔，该装置包括传感器 （1304,1306,1324,1326），用于通过所述喷嘴中的至少一个来感测所述熔体材料的选定状态; 与每个致动器相互连接的致动器控制器，所述致动器控制器互连到与所述至少一个喷嘴相关联的致动器，所述致动器包括与所述传感器互连的计算机，所述计算机接收代表由所述传感器感测的所选状态的信号，所述计算机包括算法 利用与从传感器接收的信号相对应的值。
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公开(公告)号：WO2013036671A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054004
申请日：2012-09-06
Applicant: SATORI PHARMACEUTICALS, INC. , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
IPC: C07D413/12 , C07D407/14
CPC classification number: C07J71/0005
Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein L and Ring A are as defined and described herein, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中L和环A如本文所定义和描述，其组合物及其使用方法。
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公开(公告)号：WO2013036669A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054002
申请日：2012-09-06
Applicant: SATORI PHARMACEUTICALS, INC. , BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
Inventor： BRONK, Brian, Scott , AUSTIN, Wesley, Francis , CREASER, Steffen, Phillip , FULLER, Nathan, Oliver , HUBBS, Jed, Lee , IVES, Jeffrey, Lee , SHEN, Ruichao
IPC: A61K31/58
CPC classification number: C07J71/0005
Abstract: The present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
Abstract translation: 本发明提供了可用于治疗或减轻神经变性疾病严重程度的化合物。 本发明还提供了治疗或减轻此类疾病严重程度的方法，其中所述方法包括向患者施用本发明化合物或其组合物。 所述方法可用于治疗或减轻例如阿尔茨海默病的严重性。
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