公开(公告)号：WO2005072306A2

公开(公告)日：2005-08-11

申请号：PCT/US2005/002177

申请日：2005-01-19

Applicant: MARTEK BIOSCIENCES CORPORATION ,  MORSEMAN, John, P. ,  MOSS, Mark, W. ,  ELLIS, Lorie, A.

Inventor： MORSEMAN, John, P. ,  MOSS, Mark, W. ,  ELLIS, Lorie, A.

CPC classification number: A61K31/20

Abstract: A method of measuring Reelin as a biomarker, to non-destructively assess or predict DHA levels in the brain and in other, currently inaccessible or difficult-to-access, key components of the central nervous system (CNS) is described. Also described is a method to prevent, delay the onset of, or treat Reelin deficiency or dysfunction and/or a disease or condition associated with Reelin deficiency or dysfunction, comprising administering to a patient diagnosed with or suspected of having a Reelin deficiency or dysfunction an amount of a PUFA, and particularly an omega-3 PUFA, and more particularly, docosahexaenoic acid (DHA) or a precursor or source thereof, to compensate for the effects of Reelin deficiency or dysfunction in the patient. Also described is a method to prevent or reduce development defects or disorders associated with Reelin dysfunction or deficiency through the supplemental use of polyunsaturated fatty acids (PUFAs- unsaturated fatty acids having two or more double bonds), and particularly highly unsaturated fatty acids (HUFAs- unsaturated fatty acids having three or more double bonds), and more particularly a HUFA selected from arachidonic acid (ARA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA), and even more particularly omega-3 HUFAs, and more particularly DHA, to: compensate for reduced fatty acid binding protein or function thereof in the patient; compensate for reduced brain lipid binding protein or function thereof in the patient; improve the activity of fatty acid binding proteins in the patient; increase the expression of brain lipid binding proteins (BLBPs) in the patient; improve at least one parameter of the mechanism of action of brain lipid binding proteins in the patient; overcome a deficiency of DHA in central nervous system (CNS) structures and improve the resulting function thereof; increase the incorporation of functional DHA and other PUFAs into the phospholipid membranes of glial cells and neurons in the patient; increase the level of Reelin and/or improve the activity of Reelin in the patient; and/or improve at least one symptom of a disease or condition associated with Reelin deficiency or dysfunction.

Abstract translation: 描述了测量作为生物标志物的Reelin的方法，以非破坏性地评估或预测中枢神经系统（CNS）的大脑和其他目前难以接近或难以进入的关键组分中的DHA水平。 还描述了一种防止，延迟开始或治疗Reelin缺陷或功能障碍和/或与Reelin缺陷或功能障碍相关的疾病或病症的方法，包括对诊断患有或怀疑具有Reelin缺陷或功能障碍的患者施用 PUFA，尤其是ω-3 PUFA，尤其是二十二碳六烯酸（DHA）或其前体或来源的量，以补偿患者的Reelin缺陷或功能障碍的作用。 还描述了通过补充使用多不饱和脂肪酸（具有两个或更多个双键的PUFA-不饱和脂肪酸），特别是高度不饱和脂肪酸（HUFAs-不饱和脂肪酸）来预防或减少与Reelin功能障碍或缺陷相关的发育缺陷或障碍的方法， 更具体地说，选自花生四烯酸（ARA），二十碳五烯酸（EPA），二十二碳六烯酸（DHA）和二十二碳五烯酸（DPA），甚至更特别是ω-3 HUFA的HUFA的不饱和脂肪酸 更具体地，DHA，以补偿患者中的降低的脂肪酸结合蛋白或其功能; 补偿患者脑组织中的脂质结合蛋白或其功能; 改善患者脂肪酸结合蛋白的活性; 增加患者脑部脂质结合蛋白（BLBPs）的表达; 改善患者脑组织结合蛋白的作用机制的至少一个参数; 克服中枢神经系统（CNS）结构中DHA的缺陷，改善其功能; 增加功能性DHA和其他PUFA掺入患者胶质细胞和神经元的磷脂膜中; 增加Reelin的水平和/或改善患者的Reelin的活性; 和/或改善与Reelin缺陷或功能障碍相关的疾病或病症的至少一种症状。

公开(公告)号：WO2005039914A2

公开(公告)日：2005-05-06

申请号：PCT/US2004019212

申请日：2004-06-16

Applicant: GHSP DIVISION OF JSJ CORP ,  DE JONGE ROBERT A ,  HAWVER DENNIS M ,  MITTEER DAVID M ,  BRATKOWSKI EDWARD J ,  BRYANT ERIC W ,  FISHER DANIEL J ,  WOLFFIS CRAIG A ,  MOSS MARK A

Inventor： DE JONGE ROBERT A ,  HAWVER DENNIS M ,  MITTEER DAVID M ,  BRATKOWSKI EDWARD J ,  BRYANT ERIC W ,  FISHER DANIEL J ,  WOLFFIS CRAIG A ,  MOSS MARK A

IPC: F16H59/02 ,  F16H61/22 ,  B60K

CPC classification number: F16H59/0217 ,  F16H59/0204 ,  F16H59/0278 ,  F16H61/22 ,  F16H61/24 ,  F16H63/48 ,  F16H2061/226 ,  Y10T74/20085

Abstract: A shifter includes a powered pawl mechanism that selectively engages a shift gate. The powered pawl mechanism may include an electrically operated solenoid or the like, and may be mounted to the base of the shifter or to the shift lever. The pawl engages a shift gate that is mounted on the other of the shift lever and the base. A mechanical override may be utilized to disengage the pawl. The shifter includes an electrically operated push button or the like on the shift knob, and may utilize sensors that determine the shift lever position for controlling a transmission.

Abstract translation: 换档器包括选择性地接合换档闸门的动力棘爪机构。 动力棘爪机构可以包括电操作的螺线管等，并且可以安装到换档器的底座或变速杆。 棘爪接合安装在变速杆和底座中的另一个上的换挡门。 可以利用机械超驰来使棘爪脱离。 换档器包括在换档手柄上的电动按钮等，并且可以利用确定用于控制变速器的变速杆位置的传感器。

公开(公告)号：WO2014093849A3

公开(公告)日：2014-09-18

申请号：PCT/US2013075064

申请日：2013-12-13

Applicant: SYNVENTIVE MOLDING SOLUTIONS ,  ANTUNES SERGIO RIBEIRO DE OLIVEIRA ,  ZHUANG RUI TAN ,  MOSS MARK ,  LEE CHRISTOPHER ,  FENG LING ,  GALATI VITO

Inventor： ANTUNES SERGIO RIBEIRO DE OLIVEIRA ,  ZHUANG RUI TAN ,  MOSS MARK ,  LEE CHRISTOPHER ,  FENG LING ,  GALATI VITO

IPC: B29C45/28 ,  B29C45/76 ,  B29C45/77

CPC classification number: B29C45/281 ,  B29C2045/822

Abstract: An injection molding apparatus comprising: a pneumatically driven actuator having a piston mounted within a fluid sealed chamber for slidable axial movement along or against an interior surface of the fluid sealed chamber via a non-elastomeric engagement or with a non-elastomeric material disposed between the piston and the interior surface of the fluid sealed chamber, the piston forming first and second drive chambers within the fluid sealed chamber, each drive chamber having respective fluid flow ports, a source of pressurized gas that generates gas flow at a selected maximum pressure or flow rate, a gas metering mechanism, a controller interconnected to the gas metering mechanism, the controller controllabiy moving the gas metering mechanism to selectable positions that correspond to reduced pressures or reduced flow rates during the course of pin travel from the fully downstream gate closed position to the fully upstream gate open position.

Abstract translation: 一种注射成型装置，包括：气动驱动的致动器具有安装的流体密封室，用于沿着或针对经由非弹性接合或与配置在之间的非弹性材料中的流体密封室的内表面可滑动的轴向运动的活塞 活塞和流体密封腔室的内表面，活塞在流体密封腔室内形成第一和第二驱动腔室，每个驱动腔室具有相应的流体流动端口，加压气体源，其以选定的最大压力或流量产生气流 率，气体计量机构，互连到气体计量机构的控制器，所述控制器controllabiy移动所述气体计量机构，以可选择的是销行程的过程中对应于降低的压力或降低的流率的位置从完全下游门关闭位置，以 完全上游门打开位置。

公开(公告)号：WO2002074516A1

公开(公告)日：2002-09-26

申请号：PCT/US2002/008364

申请日：2002-03-19

Applicant: SYNVENTIVE MOLDING SOLUTIONS, INC. ,  FULLER, Nathan ,  MOSS, Mark ,  KAZMER, David ,  GALATI, Vito

Inventor： FULLER, Nathan ,  MOSS, Mark ,  KAZMER, David ,  GALATI, Vito

IPC: B29C45/23

CPC classification number: B29C45/2704 ,  B29C45/27 ,  B29C45/2806 ,  B29C45/322 ,  B29C45/76 ,  B29C2045/2687 ,  B29C2045/2722 ,  B29C2045/2761 ,  B29C2045/2882 ,  B29C2045/2886

Abstract: An injection molding machine (1000) having first and second nozzles (1093, 1095) for delivering melt material to first and second mold cavities (1308, 1328) of first and second molds (1010, 1020) respectively, apparatus for controlling delivery of the melt material from the nozzles to the mold cavities, each nozzle having an exit aperture communicating with a gate of a cavity of a respective mold and being associated with an actuator (1300, 1320) interconnected to a melt flow controller, the apparatus comprising a sensor (1304, 1306, 1324, 1326) for sensing a selected condition of the melt material through at least one of the nozzles; an actuator controller interconnected to each actuator, the actuator controller interconnected to the actuator associated with the at least one nozzle comprising a computer interconnected to the sensor, the computer receiving a signal representative of the selected condition sensed by the sensor, the computer including an algorithm utilizing a value corresponding to a signal received from the sensor.

Abstract translation: 一种注塑机（1000），其具有用于将熔体材料分别输送到第一和第二模具（1010,1020）的第一和第二模腔（1308,1328）的第一和第二喷嘴（1093,1095），用于控制 将材料从喷嘴熔化到模具腔，每个喷嘴具有与相应模具的空腔的浇口连通并与互连到熔体流动控制器的致动器（1300,1320）相关联的出口孔，该装置包括传感器 （1304,1306,1324,1326），用于通过所述喷嘴中的至少一个来感测所述熔体材料的选定状态; 与每个致动器相互连接的致动器控制器，所述致动器控制器互连到与所述至少一个喷嘴相关联的致动器，所述致动器包括与所述传感器互连的计算机，所述计算机接收代表由所述传感器感测的所选状态的信号，所述计算机包括算法 利用与从传感器接收的信号相对应的值。

公开(公告)号：WO0196383A3

公开(公告)日：2002-04-11

申请号：PCT/US0119440

申请日：2001-06-18

Applicant: MARTEK BIOSCIENCES CORP ,  MORSEMAN JOHN P ,  MOSS MARK W ,  ALLNUTT F C THOMAS

Inventor： MORSEMAN JOHN P ,  MOSS MARK W ,  ALLNUTT F C THOMAS

IPC: G01N33/533 ,  G01N33/542 ,  G01N33/58

CPC classification number: G01N33/582 ,  G01N33/533 ,  G01N33/542

Abstract: In a method for quantitating an analyte by measuring time resolved transfer of fluorescence energy to or from a label quantitatively associated with the analyte, the present invention provides an improvement comprising measuring the energy transferred from donor compounds having the ability to absorb light energy and then transfer this energy to cross-linked allophycocyanin in a time-resolved manner, where the cross-linked allophycocyanin used according to this invention has not been exposed to strongly chaotropic agents after cross-linking.

Abstract translation: 在通过测量与分析物定量相关的标记物的荧光能量的时间分辨转移的方法来定量分析物的方法，本发明提供了一种改进，其包括测量从具有吸收光能并且然后转移的能力的给体化合物转移的能量 该能量以时间分辨的方式交联别藻蓝蛋白，其中根据本发明使用的交联别藻蓝蛋白在交联后未暴露于强离液剂。

公开(公告)号：WO2012178145A2

公开(公告)日：2012-12-27

申请号：PCT/US2012/043944

申请日：2012-06-25

Applicant: SYNVENTIVE MOLDING SOLUTIONS, INC. ,  MOSS, Mark, D. ,  GALATI, Vito

Inventor： MOSS, Mark, D. ,  GALATI, Vito

IPC: B29C44/10

CPC classification number: B29C44/348 ,  B29C44/3446 ,  B29C45/1704 ,  B29C45/1816 ,  B29C45/2701 ,  B29C45/2725 ,  B29C2045/1702

Abstract: An apparatus for expanding the matrix of a polymer material injected under pressure into the cavity (60c) of a mold (60), the apparatus comprising: an injection machine having a barrel (70) into which a selected polymer material is delivered, the barrel (70) comprising an elongated tubular passage terminating at a downstream end in a barrel exit port (74), the polymer material being converted within the barrel (70) to a fluid that travels as a flow under pressure; a manifold (50), one or more nozzles (64) each having a downstream exit port sealably communicating with a corresponding gate in the cavity (60c) of the mold (60); and, an injecting system (30, 30h, 30n) having an exit or outlet port (X) sealably communicating with an inlet (40) to the manifold (50) or with a channel to the manifold or with one or more of the nozzles, the injecting system injecting a selected inert fluid into the pressurized fluid polymer material.

Abstract translation: 一种用于将在压力下注入的聚合物材料的基质膨胀到模具（60）的空腔（60）中的装置，所述装置包括：注射机，其具有桶（70），所选择的聚合物材料被输送到其中 （70）包括在筒出口（74）的终止于下游端的细长管状通道，所述聚合物材料在筒体（70）内被转化为在压力下作为流动的流体; 歧管（50），一个或多个喷嘴（64），每个喷嘴具有与模具（60）的空腔（60c）中的对应浇口密封地连通的下游出口; 以及具有出口或出口（X）的注射系统（30,30h，30n），其与所述歧管（50）的入口（40）密封地连通或通向所述歧管或与所述歧管中的一个或多个喷嘴 ，所述注射系统将选定的惰性流体注入到加压流体聚合物材料中。

公开(公告)号：WO2005072306A3

公开(公告)日：2006-03-09

申请号：PCT/US2005002177

申请日：2005-01-19

Applicant: MARTEK BIOSCIENCES CORP ,  MORSEMAN JOHN P ,  MOSS MARK W ,  ELLIS LORIE A

Inventor： MORSEMAN JOHN P ,  MOSS MARK W ,  ELLIS LORIE A

IPC: A61K31/20

CPC classification number: A61K31/20

Abstract: A method of measuring Reelin as a biomarker, to non-destructively assess or predict DHA levels in the brain and in other, currently inaccessible or difficult-to-access, key components of the central nervous system (CNS) is described. Also described is a method to prevent, delay the onset of, or treat Reelin deficiency or dysfunction and/or a disease or condition associated with Reelin deficiency or dysfunction, comprising administering to a patient diagnosed with or suspected of having a Reelin deficiency or dysfunction an amount of a PUFA, and particularly an omega-3 PUFA, and more particularly, docosahexaenoic acid (DHA) or a precursor or source thereof, to compensate for the effects of Reelin deficiency or dysfunction in the patient. Also described is a method to prevent or reduce development defects or disorders associated with Reelin dysfunction or deficiency through the supplemental use of polyunsaturated fatty acids (PUFAs- unsaturated fatty acids having two or more double bonds), and particularly highly unsaturated fatty acids (HUFAs- unsaturated fatty acids having three or more double bonds), and more particularly a HUFA selected from arachidonic acid (ARA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA), and even more particularly omega-3 HUFAs, and more particularly DHA, to: compensate for reduced fatty acid binding protein or function thereof in the patient; compensate for reduced brain lipid binding protein or function thereof in the patient; improve the activity of fatty acid binding proteins in the patient; increase the expression of brain lipid binding proteins (BLBPs) in the patient; improve at least one parameter of the mechanism of action of brain lipid binding proteins in the patient; overcome a deficiency of DHA in central nervous system (CNS) structures and improve the resulting function thereof; increase the incorporation of functional DHA and other PUFAs into the phospholipid membranes of glial cells and neurons in the patient; increase the level of Reelin and/or improve the activity of Reelin in the patient; and/or improve at least one symptom of a disease or condition associated with Reelin deficiency or dysfunction.

Abstract translation: 描述了测量作为生物标志物的Reelin的方法，以非破坏性地评估或预测中枢神经系统（CNS）的大脑和其他目前难以接近或难以进入的关键组分中的DHA水平。 还描述了一种防止，延迟开始或治疗Reelin缺陷或功能障碍和/或与Reelin缺陷或功能障碍相关的疾病或病症的方法，包括对诊断患有或怀疑具有Reelin缺陷或功能障碍的患者施用 PUFA，尤其是ω-3 PUFA，尤其是二十二碳六烯酸（DHA）或其前体或来源的量，以补偿患者的Reelin缺陷或功能障碍的作用。 还描述了通过补充使用多不饱和脂肪酸（具有两个或更多个双键的PUFA-不饱和脂肪酸），特别是高度不饱和脂肪酸（HUFAs-不饱和脂肪酸）来预防或减少与Reelin功能障碍或缺陷相关的发育缺陷或障碍的方法， 更具体地说，选自花生四烯酸（ARA），二十碳五烯酸（EPA），二十二碳六烯酸（DHA）和二十二碳五烯酸（DPA），甚至更特别是ω-3 HUFA的HUFA的不饱和脂肪酸 更具体地，DHA，以补偿患者中的降低的脂肪酸结合蛋白或其功能; 补偿患者脑组织中的脂质结合蛋白或其功能; 改善患者脂肪酸结合蛋白的活性; 增加患者脑部脂质结合蛋白（BLBPs）的表达; 改善患者脑组织结合蛋白的作用机制的至少一个参数; 克服中枢神经系统（CNS）结构中DHA的缺陷，改善其功能; 增加功能性DHA和其他PUFA掺入患者胶质细胞和神经元的磷脂膜中; 增加Reelin的水平和/或改善患者的Reelin的活性; 和/或改善与Reelin缺陷或功能障碍相关的疾病或病症的至少一种症状。

公开(公告)号：WO2012178145A3

公开(公告)日：2013-07-04

申请号：PCT/US2012043944

申请日：2012-06-25

Applicant: SYNVENTIVE MOLDING SOLUTIONS ,  MOSS MARK D ,  GALATI VITO

Inventor： MOSS MARK D ,  GALATI VITO

IPC: B29C45/18 ,  B29C45/27

CPC classification number: B29C44/348 ,  B29C44/3446 ,  B29C45/1704 ,  B29C45/1816 ,  B29C45/2701 ,  B29C45/2725 ,  B29C2045/1702

Abstract: An apparatus for expanding the matrix of a polymer material injected under pressure into the cavity (60c) of a mold (60), the apparatus comprising: an injection machine having a barrel (70) into which a selected polymer material is delivered, the barrel (70) comprising an elongated tubular passage terminating at a downstream end in a barrel exit port (74), the polymer material being converted within the barrel (70) to a fluid that travels as a flow under pressure; a manifold (50), one or more nozzles (64) each having a downstream exit port sealably communicating with a corresponding gate in the cavity (60c) of the mold (60); and, an injecting system (30, 30h, 30n) having an exit or outlet port (X) sealably communicating with an inlet (40) to the manifold (50) or with a channel to the manifold or with one or more of the nozzles, the injecting system injecting a selected inert fluid into the pressurized fluid polymer material.

Abstract translation: 一种用于将在压力下注入的聚合物材料的基质膨胀到模具（60）的空腔（60）中的装置，所述装置包括：注射机，其具有桶（70），所选择的聚合物材料被输送到其中 （70）包括在筒出口（74）的终止于下游端的细长管状通道，所述聚合物材料在筒体（70）内被转化为在压力下作为流动的流体; 歧管（50），一个或多个喷嘴（64），每个喷嘴具有与模具（60）的空腔（60c）中的对应浇口密封地连通的下游出口; 以及具有出口或出口（X）的注射系统（30,30h，30n），其与所述歧管（50）的入口（40）密封地连通或通向所述歧管或与一个或多个所述喷嘴 ，所述注射系统将选定的惰性流体注入到加压流体聚合物材料中。

公开(公告)号：WO2001060580A1

公开(公告)日：2001-08-23

申请号：PCT/US2001/004674

申请日：2001-02-13

Applicant: DYNISCO HOTRUNNERS, INC. ,  KAZMER, David ,  MOSS, Mark, D. ,  DOYLE, Mark

Inventor： KAZMER, David ,  MOSS, Mark, D. ,  DOYLE, Mark

IPC: B29C45/28

CPC classification number: B29C45/2701 ,  B29C45/2806 ,  B29C45/281 ,  B29C45/30 ,  B29C45/76 ,  B29C45/77 ,  B29C2045/2687 ,  B29C2045/2722 ,  B29C2045/279 ,  B29C2045/2817 ,  B29C2045/2872 ,  B29C2045/2882 ,  B29C2045/2886 ,  B29C2045/304 ,  B29C2045/306 ,  B29C2945/76006 ,  B29C2945/76083 ,  B29C2945/76187 ,  B29C2945/76277 ,  B29C2945/76381 ,  B29C2945/76545 ,  B29C2945/76752 ,  B29C2945/76765 ,  B29C2945/76859 ,  B29C2945/76943

Abstract: An injection molding apparatus and system are provided in which the rate of material flow during the injection cycle is controlled. According to one preferred embodiment, an injection molding system is provided that includes an injection molding machine including a hydraulic power source, a manifold for distributing material injected from said injection molding machine to a plurality of gates leading to one or more mold cavities, and a controller to individually control respective rates at which material is injected through said gates during an injection cycle. The controller is coupled to the hydraulic power source and the hydraulic power source supplies hydraulic power to both the injection molding machine and to control said respective rates.

Abstract translation: 提供注射成型装置和系统，其中控制注射循环期间的物料流速。 根据一个优选实施例，提供一种注射成型系统，其包括注射成型机，该注射成型机包括液压动力源，用于将从所述注射成型机注入的材料分配到通向一个或多个模腔的多个门的歧管，以及 控制器单独地控制在注射周期期间材料通过所述浇口注入的各个速率。 控制器耦合到液压动力源，液压动力源向注射成型机提供液压动力并控制所述相应的速率。

公开(公告)号：WO2014093849A2

公开(公告)日：2014-06-19

申请号：PCT/US2013/075064

申请日：2013-12-13

Applicant: SYNVENTIVE MOLDING SOLUTIONS, INC. ,  ANTUNES, Sergio Ribeiro De Oliveira ,  ZHUANG, Rui Tan ,  MOSS, Mark ,  LEE, Christopher ,  FENG, Ling ,  GALATI, Vito

Inventor： ANTUNES, Sergio Ribeiro De Oliveira ,  ZHUANG, Rui Tan ,  MOSS, Mark ,  LEE, Christopher ,  FENG, Ling ,  GALATI, Vito

IPC: B29C45/76

CPC classification number: B29C45/281 ,  B29C2045/822

Abstract: An injection molding apparatus comprising: a pneumatically driven actuator having a piston mounted within a fluid sealed chamber for slidable axial movement along or against an interior surface of the fluid sealed chamber via a non-elastomeric engagement or with a non-elastomeric material disposed between the piston and the interior surface of the fluid sealed chamber, the piston forming first and second drive chambers within the fluid sealed chamber, each drive chamber having respective fluid flow ports, a source of pressurized gas that generates gas flow at a selected maximum pressure or flow rate, a gas metering mechanism, a controller interconnected to the gas metering mechanism, the controller controllabiy moving the gas metering mechanism to selectable positions that correspond to reduced pressures or reduced flow rates during the course of pin travel from the fully downstream gate closed position to the fully upstream gate open position.

Abstract translation: 一种注射成型设备，包括：气动驱动的致动器，其具有安装在流体密封室内的活塞，用于通过非弹性接合或非弹性材料沿着或抵靠流体密封室的内表面可滑动地轴向运动， 活塞和流体密封室的内表面，活塞在流体密封室内形成第一和第二驱动室，每个驱动室具有相应的流体流动端口，在选定的最大压力或流动下产生气流的加压气体源 速率，气体计量机构，与气体计量机构相互连接的控制器，控制器可控制地将气体计量机构移动到可选择的位置，其对应于从完全下游门关闭位置到销的行程期间的减小的压力或降低的流速， 完全上游闸门打开位置。