公开(公告)号：WO2012054824A3

公开(公告)日：2012-07-19

申请号：PCT/US2011057271

申请日：2011-10-21

Applicant: VERMILLION INC ,  HOGDALL ESTRID ,  FUNG ERIC T ,  CHRISTENSEN IB JARLE ,  HOGDALL CLAUS

Inventor： HOGDALL ESTRID ,  FUNG ERIC T ,  CHRISTENSEN IB JARLE ,  HOGDALL CLAUS

IPC: G01N33/574 ,  G01N30/00 ,  G01N33/543 ,  G01N33/68

CPC classification number: G01N33/57449 ,  G01N27/44778 ,  G01N2030/8831 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56

Abstract: The present invention provides methods for assessing an ovarian cancer patient's survival status. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass spectrometry systems and other techniques.

Abstract translation: 本发明提供了评估卵巢癌患者生存状态的方法。 此外，本文描述了用于评估患者的卵巢癌状态的方法。 这些方法涉及生物样品中生物样本的检测，分析和分类。 使用例如质谱系统和其它技术获得生物学模式。

公开(公告)号：WO2008123948A1

公开(公告)日：2008-10-16

申请号：PCT/US2008/004088

申请日：2008-03-27

Applicant: VERMILLION, INC. ,  MD ANDERSON CANCER RESEARCH CENTER ,  FUNG, Eric, Thomas ,  BAST, Robert ,  PODUST, Vladimir ,  CLARKE, Charlotte

Inventor： FUNG, Eric, Thomas ,  BAST, Robert ,  PODUST, Vladimir ,  CLARKE, Charlotte

IPC: G01N33/53 ,  C07K16/00

CPC classification number: G01N33/57449 ,  G01N33/5091 ,  G01N2800/56 ,  G01N2800/60

Abstract: The present invention provides protein-based biomarkers andjbiomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, it has been found that the biomarkers set forth in Table 1 are biomarkers for ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.

Abstract translation: 本发明提供了可用于评估患者卵巢癌状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，已经发现表1中列出的生物标志物是卵巢癌的生物标志物。 生物标志物可以通过SELDI质谱检测。

公开(公告)号：WO2008057806A1

公开(公告)日：2008-05-15

申请号：PCT/US2007/082730

申请日：2007-10-26

Applicant: VERMILLION, INC. ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY ,  FUNG, Eric T. ,  COOKE, John ,  ZHANG, Fujun ,  WILSON, Andrew

Inventor： FUNG, Eric T. ,  COOKE, John ,  ZHANG, Fujun ,  WILSON, Andrew

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/72 ,  G01N33/74

CPC classification number: G01N33/66 ,  G01N33/6893 ,  G01N2333/4737 ,  G01N2333/70539 ,  G01N2333/8139 ,  G01N2800/323

Abstract: The invention provides biomarkers including ß -2-microglobulin, Cystatin C, hsCRP and glucose as well as methods for using the biomarkers for diagnosing and/or assessing the risk of peripheral artery disease in a subject. In some embodiments, the subject being tested may be suffering from or at risk of other circulatory diseases, including coronary artery disease.

Abstract translation: 本发明提供包括β-2-微球蛋白，半胱氨酸蛋白酶抑制剂C，hsCRP和葡萄糖的生物标志物，以及使用生物标志物来诊断和/或评价受试者中外周动脉疾病风险的方法。 在一些实施方案中，被测试的受试者可能患有或具有其他循环系统疾病（包括冠状动脉疾病）的风险。

公开(公告)号：WO2007106466A3

公开(公告)日：2007-12-13

申请号：PCT/US2007006276

申请日：2007-03-12

Applicant: UNIV LELAND STANFORD JUNIOR ,  CIPHERGEN BIOSYSTEMS INC ,  AJINOMOTO KK ,  COOKE JOHN ,  FUNG ERIC T ,  KIMURA EIICHIRO

Inventor： COOKE JOHN ,  FUNG ERIC T ,  KIMURA EIICHIRO

IPC: G01N33/566 ,  G01N33/567

CPC classification number: G01N33/564 ,  G01N33/6893 ,  G01N2800/323 ,  G01N2800/52

Abstract: The present invention provides ß2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.

Abstract translation: 本发明提供了β2微球蛋白作为用于鉴定或评估受试者中外周动脉疾病的生物标志物。

公开(公告)号：WO2007106466A2

公开(公告)日：2007-09-20

申请号：PCT/US2007/006276

申请日：2007-03-12

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  CIPHERGEN BIOSYSTEMS, INC. ,  AJINOMOTO CO., INC. ,  COOKE, John ,  FUNG, Eric T. ,  KIMURA, Eiichiro

Inventor： COOKE, John ,  FUNG, Eric T. ,  KIMURA, Eiichiro

IPC: G06F19/00 ,  G01N33/53

CPC classification number: G01N33/564 ,  G01N33/6893 ,  G01N2800/323 ,  G01N2800/52

Abstract: The present invention provides ß2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.

Abstract translation: 本发明提供β2微球蛋白作为用于鉴定或评估受试者中外周动脉疾病的生物标志物。

公开(公告)号：WO2007002527A9

公开(公告)日：2007-05-24

申请号：PCT/US2006024677

申请日：2006-06-23

Applicant: CIPHERGEN BIOSYSTEMS INC ,  FUNG ERIC THOMAS ,  DALMASSO ENRIQUE ,  PODUST VALDIMIR ,  WANG ZHENG

Inventor： FUNG ERIC THOMAS ,  DALMASSO ENRIQUE ,  PODUST VALDIMIR ,  WANG ZHENG

IPC: G01N33/574 ,  G01N33/68

CPC classification number: G01N33/6851 ,  G01N33/57449 ,  G01N2333/70539 ,  G01N2500/04

Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.

Abstract translation: 本发明提供了用于鉴定患者的卵巢癌状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌或非卵巢癌。 生物标记可以通过SELDI质谱法检测。

公开(公告)号：WO2007002069A2

公开(公告)日：2007-01-04

申请号：PCT/US2006023954

申请日：2006-06-20

Applicant: GONCALVES ANTHONY ,  BORG JEAN-PAUL ,  FUNG ERIC THOMAS ,  MENG XIAO-YING

Inventor： GONCALVES ANTHONY ,  BORG JEAN-PAUL ,  FUNG ERIC THOMAS ,  MENG XIAO-YING

IPC: G01N33/574 ,  A61P35/00 ,  C07K14/775 ,  C07K16/00 ,  G06F19/00

CPC classification number: G01N33/57415

Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention are useful to determine metastasis-free survival of breast cancer patients. The biomarkers can be detected by SELDI mass spectrometry.

Abstract translation: 本发明提供了可用于评估患者乳腺癌状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，本发明的生物标志物可用于确定乳腺癌患者的无转移生存。 生物标志物可以通过SELDI质谱检测。

公开(公告)号：WO2005098446A3

公开(公告)日：2005-10-20

申请号：PCT/US2005/010679

申请日：2005-03-30

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  CIPHERGEN BIOSYSTEMS, INC. ,  CHAN, Daniel, W. ,  ZHANG, Zhen ,  FUNG, Eric

Inventor： CHAN, Daniel, W. ,  ZHANG, Zhen ,  FUNG, Eric

IPC: G01N33/48 ,  C12Q1/00

Abstract: The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.

公开(公告)号：WO2005043111A2

公开(公告)日：2005-05-12

申请号：PCT/US2004/022777

申请日：2004-07-14

Applicant: CIPHERGEN BIOSYSTEMS, INC. ,  KANG, Xixiong ,  TANG, Hong ,  WU, Xiaoyi ,  FUNG, Eric ,  GUO, Junhua ,  XU, Yang ,  ZHANG, Fujun

Inventor： KANG, Xixiong ,  TANG, Hong ,  WU, Xiaoyi ,  FUNG, Eric ,  GUO, Junhua ,  XU, Yang ,  ZHANG, Fujun

IPC: G01N

CPC classification number: G01N33/56983 ,  G01N2333/165

Abstract: The present invention provides biomarkers and biomarker combinations that are useful in qualifying SARS status in a patient. In addition, the present invention provides diagnostic methodology employing these biomarkers and combinations thereof that can distinguish between SARS and normal.

Abstract translation: 本发明提供可用于鉴定患者中SARS状态的生物标志物和生物标志物组合。 此外，本发明提供了使用这些可以区分SARS和正常的生物标志物及其组合的诊断方法。

公开(公告)号：WO2004012588A2

公开(公告)日：2004-02-12

申请号：PCT/US2003/024636

申请日：2003-08-06

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  CIPHERGEN BIOSYSTEMS, INC. ,  CHAN, Daniel, W. ,  ZHANG, Zhen ,  FUNG, Eric ,  MENG, Xiao-Ying

Inventor： CHAN, Daniel, W. ,  ZHANG, Zhen ,  FUNG, Eric ,  MENG, Xiao-Ying

IPC: A61B

CPC classification number: G01N33/543 ,  G01N33/57449 ,  Y10S435/807 ,  Y10S435/967 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/815 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/24 ,  Y10T436/255

Abstract: The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.

Abstract translation: 本发明涉及鉴定受试者卵巢癌状态的方法，其包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量结果与卵巢癌状态 。 本发明进一步涉及用于鉴定受试者的卵巢癌状态的试剂盒。