公开(公告)号：WO2012065095A3

公开(公告)日：2013-04-18

申请号：PCT/US2011060422

申请日：2011-11-11

Applicant: UNIV SOUTH CAROLINA ,  MUKHERJEE RUPAK ,  GOLD MICHAEL R ,  SPINALE FRANCIS G

Inventor： MUKHERJEE RUPAK ,  GOLD MICHAEL R ,  SPINALE FRANCIS G

IPC: G01N33/53

CPC classification number: G01N33/6887 ,  A61B18/12 ,  A61N1/362 ,  G01N33/573 ,  G01N2333/8146 ,  G01N2333/96494 ,  G01N2800/326

Abstract: Disclosed herein are methods of and systems for predicting recurrence of atrial fibrillation comprising protease and protease inhibitor profiling. An exemplary method comprises: measuring MMP-9, MMP-3, and TIMP-4 levels in a body fluid from a subject with a history of atrial fibrillation to produce an MMP/TIMP profile; and using the MMP/TIMP profile to determine whether the subject will have a recurrence of atrial fibrillation following a cardioversion procedure.

Abstract translation: 本文公开了用于预测心包颤动复发的方法和系统，其包括蛋白酶和蛋白酶抑制剂分析。 示例性方法包括：测量具有心房颤动史的患者的体液中的MMP-9，MMP-3和TIMP-4水平以产生MMP / TIMP谱; 并使用MMP / TIMP分布来确定受试者在心脏复律术后是否会复发房颤。

公开(公告)号：WO2012065095A2

公开(公告)日：2012-05-18

申请号：PCT/US2011/060422

申请日：2011-11-11

Applicant: MEDICAL UNIVERSITY OF SOUTH CAROLINA ,  MUKHERJEE, Rupak ,  GOLD, Michael, R. ,  SPINALE, Francis, G.

Inventor： MUKHERJEE, Rupak ,  GOLD, Michael, R. ,  SPINALE, Francis, G.

IPC: C12Q1/37

CPC classification number: G01N33/6887 ,  A61B18/12 ,  A61N1/362 ,  G01N33/573 ,  G01N2333/8146 ,  G01N2333/96494 ,  G01N2800/326

Abstract: Disclosed herein are methods of and systems for predicting recurrence of atrial fibrillation comprising protease and protease inhibitor profiling.

Abstract translation: 本文公开了用于预测心包颤动复发的方法和系统，其包括蛋白酶和蛋白酶抑制剂分析。

公开(公告)号：WO2008085895A3

公开(公告)日：2008-07-17

申请号：PCT/US2008/000125

申请日：2008-01-04

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT ,  MUKHERJEE, Rupak ,  GOLD, Michael, R. ,  SPINALE, Francis, G.

Inventor： MUKHERJEE, Rupak ,  GOLD, Michael, R. ,  SPINALE, Francis, G.

IPC: A61B5/02 ,  A61B5/04 ,  A61N1/08

Abstract: Disclosed herein are methods of and systems for predicting recurrence of atrial fibrillation comprising protease and protease inhibitor profiling. The levels of matrix metalloproteinases (MMPs) and/or tissue inhibitor metalloproteinases (TIMPs) are analyzed to predict the recurrence of atrial fibrillation, and further to predict whether cardioversion will provide a successful therapy.

公开(公告)号：WO2008085895A2

公开(公告)日：2008-07-17

申请号：PCT/US2008000125

申请日：2008-01-04

Applicant: MUSC FOUND FOR RES DEV ,  MUKHERJEE RUPAK ,  GOLD MICHAEL R ,  SPINALE FRANCIS G

Inventor： MUKHERJEE RUPAK ,  GOLD MICHAEL R ,  SPINALE FRANCIS G

IPC: A61B5/02

CPC classification number: G01N33/6893 ,  A61B5/046 ,  A61B18/1492 ,  A61B2018/00357 ,  A61N1/395 ,  G01N2333/8146 ,  G01N2333/96494 ,  G01N2800/326 ,  G01N2800/54

Abstract: Disclosed herein are methods of and systems for predicting recurrence of atrial fibrillation comprising protease and protease inhibitor profiling.

Abstract translation: 本文公开了用于预测心包颤动复发的方法和系统，其包括蛋白酶和蛋白酶抑制剂分析。