公开(公告)号：WO2019157359A1

公开(公告)日：2019-08-15

申请号：PCT/US2019/017322

申请日：2019-02-08

申请人： FARAPULSE, INC.

发明人： VISWANATHAN, Raju

IPC分类号： A61B18/12 ,  A61B18/14 ,  A61N1/362 ,  A61N1/32 ,  A61N1/05

CPC分类号： A61B18/1492 ,  A61B18/1206 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00708 ,  A61B2018/00827 ,  A61B2018/00988 ,  A61B2018/124 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61N1/05 ,  A61N1/08 ,  A61N1/327 ,  A61N1/362 ,  A61N1/3621

摘要： Systems, devices, and methods for current control of energy delivery to ablate tissue are disclosed. A generator may include a set of electrode channels coupled to a set of electrodes during use. Each electrode channel from the set of electrode channels may include a first switch from a first set of switches and a second switch from a second set of switches. A set of energy sources may be coupled to a third set of switches. The third set of switches may be configured to switch from an OFF state to an ON state to couple the set of energy sources to the set of electrodes. A set of resistors may be coupled to the second set of switches. The second set of switches may be configured to switch from an OFF state to an ON state to couple the set of resistors to the set of electrodes.

公开(公告)号：WO2019089539A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058140

申请日：2018-10-30

申请人： CARDIAC PACEMAKERS, INC.

发明人： SHUROS, Allan C. ,  CASAVANT, David Arthur

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61N1/362 ,  A61N1/368

CPC分类号： A61N1/368 ,  A61B5/0452 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36507 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/371 ,  A61N1/3712

摘要： Systems and methods for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses for delivery at or near a His bundle of the heart. A control circuit may time the delivery of the HBP pulses within a tissue refractory period subsequent to an intrinsic His-bundle activation of a first His-bundle portion. Based on an evoked His-bundle activation of a second His-bundle portion, the system may determine whether correction of intra-Hisian block has occurred. The system additionally includes a threshold test circuit to determine an individualized pacing threshold representing minimal energy to excite the His bundle and to correct the cardiac conduction abnormality.

公开(公告)号：WO2019050438A1

公开(公告)日：2019-03-14

申请号：PCT/RU2018/050108

申请日：2018-09-07

申请人： АЛЕКСАНДРОВ, Александр Николаевич

发明人： АЛЕКСАНДРОВ, Александр Николаевич

IPC分类号： A61N1/362 ,  H01R31/06 ,  H01R103/00

CPC分类号： A61N1/362 ,  H01R31/06

摘要： Изобретение относится к медицинской технике, а именно к устройствам для временной электрической стимуляции сердечной мышцы. Переходник к деимплантированному кардиостимулятору для временной электрокардиостимуляции, имеет проксимальную часть в виде изоляционного корпуса с уплотнительными кольцами и первым и вторым контактными штырями, и дистальную часть с гибкой изоляционной трубкой, в полости которой размещены первый и второй спиральные токопроводящие провода, причем первый спиральный токопроводящий провод одним своим концом соединен с первым контактным штырем, причем второй спиральный токопроводящий провод одним своим концом соединен со вторым контактным штырем, который коаксиален первому контактному штырю, отличающийся тем, что первый спиральный токоприводящий провод другим своим концом соединен с первым электрическим разъемом типа «банан», предназначенным для подсоединения к отрицательному проксимальному полюсу электрода для временной электрокардиостимуляции, а второй спиральный токоприводящий провод другим своим концом соединен со вторым электрическим разъемом типа «банан», предназначенным для подсоединения к положительному проксимальному полюсу электрода для временной электрокардиостимуляции. Изобретение позволяет изменить функциональные возможности переходника и использовать постоянные имплантируемые электрокардиостимуляторы для временной электрокардиостимуляции без их имплантации пациенту.

公开(公告)号：WO2017132000A1

公开(公告)日：2017-08-03

申请号：PCT/US2017/013722

申请日：2017-01-17

申请人： MEDTRONIC, INC.

发明人： YODER, Matthew R. ,  ZHANG, Bo ,  KIVI, Gary P. ,  SANDEN, Richard A.

IPC分类号： A61N1/372 ,  A61N1/37 ,  A61N1/39 ,  A61M5/14 ,  A61N1/05 ,  A61N1/36 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61N1/37252 ,  A61M5/14276 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61M2205/52 ,  A61N1/0563 ,  A61N1/0568 ,  A61N1/0573 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/362 ,  A61N1/36507 ,  A61N1/36564 ,  A61N1/37217 ,  A61N1/3956 ,  G16H40/67

摘要： Systems, apparatus, methods and computer-readable storage media that facilitate monitoring the integrity of telemetry connectivity between an implantable device and an external device are provided. In one embodiment, an implantable device includes a monitoring component that monitors advertisement signal information identifying an amount of advertisement signals transmitted to the external device within a defined time period, and telemetry session information identifying an amount of the telemetry sessions that are established between the external device and the implantable device within the defined time period. A connectivity assessment component of the implantable device further determines whether a telemetry connectivity problem exists between the external device and the implantable device based on a degree of miscorrelation between the advertisement signal information and the telemetry session information.

摘要翻译： 提供了便于监测可植入设备和外部设备之间的遥测连接的完整性的系统，设备，方法和计算机可读存储介质。 在一个实施例中，可植入设备包括监视组件，该监视组件监视标识在定义的时间段内向外部设备传送的广告信号的量的广告信号信息，以及遥测会话信息，标识在外部设备之间建立的遥测会话的数量 装置和植入式装置在限定的时间段内。 可植入设备的连接性评估组件还基于广告信号信息和遥测会话信息之间的错误相关程度来确定外部设备和可植入设备之间是否存在遥测连接性问题。

公开(公告)号：WO2017127548A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014139

申请日：2017-01-19

申请人： CARDIAC PACEMAKERS, INC. ,  NDSU RESEARCH FOUNDATION

发明人： MAILE, Keith R. ,  BRAATEN, Benjamin ,  EWERT, Daniel

IPC分类号： A61N1/375 ,  A61N1/378 ,  A61N1/36 ,  A61N1/38 ,  A61N1/372 ,  H01Q1/38 ,  H01Q3/24 ,  H01Q9/42

CPC分类号： A61N1/3787 ,  A61N1/36 ,  A61N1/362 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/3756

摘要： Implantable medical devices such as leadless cardiac pacemakers may include a rechargeable battery, and a receiving antenna for receiving radiative energy from an external transmitter. Energy captured by the receiving antenna of the implantable medical device may be converted into electrical energy that may be used to recharge the rechargeable battery of the implantable medical device. Since the rechargeable battery does not have to initially store sufficient energy to power the implantable medical device over its entire useful life, the battery itself and thus the implanted medical device can be made smaller while still achieving device longevity expectations.

摘要翻译： 诸如无引线心脏起搏器的植入式医疗设备可以包括可充电电池和用于从外部发射器接收辐射能量的接收天线。 由可植入医疗装置的接收天线捕获的能量可以被转换成可用于对可植入医疗装置的可再充电电池进行再充电的电能。 由于可充电电池在其整个使用寿命中不必首先存储足够的能量来为植入式医疗装置供电，因此电池本身以及因此植入的医疗装置可以制造得更小，同时仍然实现装置寿命预期。

公开(公告)号：WO2017123051A1

公开(公告)日：2017-07-20

申请号：PCT/KR2017/000480

申请日：2017-01-13

申请人： 민규식

发明人： 민규식

IPC分类号： A61N1/375 ,  A61N1/362 ,  A61B5/00

CPC分类号： A61B5/00 ,  A61N1/362 ,  A61N1/375

摘要： 본 개시에서는 제 1 면과 제 2 면을 가지는 부도체인 피드스루 기판과; 피드스루 기판의 제 1 면으로 노출된 단자와 단자에 연결되고 피드스루 기판 외부로 노출되지 않는 몸체를 갖는 하나 이상의 제 1 피드스루 전도체; 및, 피드스루 기판의 제 2 면으로 노출된 단자와 단자에 연결되고 피드스루 기판 외부로 노출되지 않는 몸체를 가지며, 제 1 피드스루 전도체 각각과 일대일로 대응되어 쌍을 이루는 하나 이상의 제 2 피드스루 전도체; 를 포함하고, 각각의 제 1 피드스루 전도체의 몸체와 그에 대응되는 제 2 피드스루 전도체의 몸체는 서로 용량성 결합(capacitive coupling) 되도록 배치되는 피드스루 장치를 제공한다.

摘要翻译： 本公开涉及一种馈通衬底，该馈通衬底是具有第一侧和第二侧的非导体; 馈通连接到终端，并暴露于所述基板的所述第一表面和终端通过基板供给具有不暴露于过导体的外侧的主体的一个或多个第一进料; 并且，如权利要求连接到该终端的一个馈通和终端暴露于所述基板的第二表面，并通过所述基板送入具有非身体暴露到外部，第一馈通导体与相关的每一个对一具有一个或多个第二馈通在一对 导体; 其中每个第一馈通导体的主体和第二馈通导体的相应主体被布置为彼此电容耦合。

公开(公告)号：WO2017118986A2

公开(公告)日：2017-07-13

申请号：PCT/IL2017/050020

申请日：2017-01-05

申请人： THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER

发明人： YANKELSON, Lior ,  SHEZIFI, Omer ,  PINHASOV, Dima

IPC分类号： A61N1/05

CPC分类号： A61N1/362 ,  A61B5/0422 ,  A61B5/6852 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00297 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61N1/056 ,  A61N1/057

摘要： An electrode array configured to be inserted at least partially into a blood vessel including: a self-expandable array body; at least two axially spaced-apart electrodes connected to said array body; wherein at least part of said array body expands to an open conformation and pushes at least one selected electrode against a blood vessel inner tissue with a force designed not to damage venous tissue.

公开(公告)号：WO2017062455A1

公开(公告)日：2017-04-13

申请号：PCT/US2016/055500

申请日：2016-10-05

申请人： WICHITA STATE UNIVERSITY ,  FARHOUD, Hussam

发明人： FARHOUD, Hussam ,  CHEN, Zheng ,  CLUFF, Kim ,  ASMATULU, Ramazan ,  PATTERSON, Jeremy

IPC分类号： A61N1/362 ,  A61F2/02 ,  A61F2/00

CPC分类号： A61N1/362 ,  A61M1/10 ,  A61M1/1058 ,  A61M1/1068 ,  A61M1/12 ,  A61M2205/0283

摘要： An electroactive polymer actuator useful in biomedical applications is disclosed. The electroactive polymer includes a dielectric elastomer film with a metallic mesh embedded therein, and two electrodes, each coating a respective major surface of the film. In some aspects, a cardiac assist device using such an electroactive polymer actuator is disclosed. The cardiac assist device includes a sleeve that substantially surrounds a persons heart and that is electrically insulated from its surroundings. Optionally, the cardiac assist device includes multiple regions connected to a power source in such a way that each region can be activated independently from the others. In other aspects, a method of using such a cardiac assist device to contract a heart is disclosed. A voltage is applied to the metallic mesh and the electrodes are grounded creating respective electric fields between the metallic mesh and each electrode, causing the cardiac assist device to contract.

摘要翻译： 公开了一种可用于生物医学应用的电活性聚合物致动器。 电活性聚合物包括其中嵌有金属网的介电弹性体膜和两个电极，每个电极涂覆膜的相应主表面。 在一些方面，公开了使用这种电活性聚合物致动器的心脏辅助装置。 心脏辅助装置包括基本上围绕人的心并且与其周围环境电绝缘的套管。 可选地，心脏辅助装置包括连接到电源的多个区域，使得每个区域可以独立于其它区域被激活。 在其他方面，公开了一种使用这种心脏辅助装置收缩心脏的方法。 电压被施加到金属网上，电极接地，在金属网和每个电极之间产生相应的电场，引起心脏辅助装置收缩。

公开(公告)号：WO2017031173A8

公开(公告)日：2017-04-13

申请号：PCT/US2016047290

申请日：2016-08-17

申请人： UNIV OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： CUI XINYAN ,  SNYDER NOAH ,  CATT KASEY ,  ELES JAMES

IPC分类号： C07F13/00 ,  A61L27/28 ,  A61L29/08 ,  A61L31/08 ,  C07D487/22 ,  C07F3/02 ,  C07F15/02

CPC分类号： C07F13/005 ,  A61B5/04001 ,  A61B17/68 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61C8/0013 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0067 ,  A61L26/008 ,  A61L27/28 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/404 ,  A61M25/0017 ,  A61M2205/0205 ,  A61N1/3605 ,  A61N1/362 ,  C07D487/22 ,  C07F3/02 ,  C07F15/025 ,  C08K5/3432 ,  C09D5/1625 ,  C08L77/00

摘要： Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, antiinflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface. The porphyrine compounds are characterized by having the following group attached to the porphyrine core through a carboxylate ester group. A is independently an optionally substituted N-heterocyclic aromatic ring; x is independently an integer from 0 to 6; R2 is independently lower aminoalkyl or lower aminoaryl.

摘要翻译： 本文公开了新的胺官能化卟啉化合物，作为其药学上可接受的盐或酯的孔。 所公开的化合物可用于向有需要的表面或诸如医用植入物或海洋表面的表面赋予抗氧化剂，抗炎，抗微生物和/或细胞粘附特异性。 卟吩化合物的特征在于通过羧酸酯基团将下列基团连接到卟啉核心。 A独立地是任选取代的N-杂环芳环; x独立地为0至6的整数; R2独立地为低级氨基烷基或低级氨基芳基。

公开(公告)号：WO2017044269A1

公开(公告)日：2017-03-16

申请号：PCT/US2016/047375

申请日：2016-08-17

申请人： CPG TECHNOLOGIES, LLC.

发明人： CORUM, James, F. ,  CORUM, Kenneth, L. ,  CARLTON, Paul, Kendall ,  PINZONE, Joseph, F.

IPC分类号： A61N1/372 ,  A61N1/362 ,  A61N1/39 ,  A61N1/365

CPC分类号： H02J50/10 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/04001 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1107 ,  A61B5/14542 ,  A61B2560/0219 ,  A61N1/36007 ,  A61N1/36139 ,  A61N1/362 ,  A61N1/365 ,  A61N1/37211 ,  A61N1/3787 ,  A61N1/39 ,  H01P3/00 ,  H02J3/16 ,  H02J50/80

摘要： Disclosed is an implantable medical device and methods of using the medical device. The medical device may include a guided surface wave receive structure configured to receive a guided surface wave transmitted by a guided surface waveguide probe. The guided surface wave receive structure in the medical device generates an alternating current signal when the guided surface wave is received. The medical device includes a power circuit that is coupled to the guided surface wave receive structure. The power circuit includes a power storage circuit to store the power signal. The medical device includes a medical circuit that comprises a stimulus circuit, a monitoring circuit, and potentially other components. The stimulus circuit provides a stimulus to a human body. The monitoring circuit measures a characteristic of the human body.

摘要翻译： 公开了可植入医疗装置和使用该医疗装置的方法。 医疗装置可以包括被配置为接收由导向波导探针传输的引导表面波的引导表面波接收结构。 当接收到被引导表面波时，医疗装置中的引导表面波接收结构产生交流信号。 医疗装置包括耦合到被引导表面波接收结构的电力电路。 电源电路包括用于存储电力信号的电力存储电路。 医疗装置包括医疗电路，其包括刺激电路，监视电路和潜在的其他部件。 刺激电路为人体提供刺激。 监控电路测量人体的特征。