公开(公告)号：WO2010147820A1

公开(公告)日：2010-12-23

申请号：PCT/US2010/037943

申请日：2010-06-09

Applicant: ISP INVESTMENTS INC. ,  PREMACHANDRAN, Raman ,  GOMEZ, Blanca ,  NARAYANAN, Kolazi, S. ,  WINKOWSKI, Karen

Inventor： PREMACHANDRAN, Raman ,  GOMEZ, Blanca ,  NARAYANAN, Kolazi, S. ,  WINKOWSKI, Karen

IPC: A01N25/08 ,  A01N43/80

CPC classification number: A01N25/04 ,  A01N43/40 ,  A01N43/653 ,  A01N43/80 ,  A01N47/12

Abstract: A stabilized biocidal dispersion comprising a biocide coated or adsorbed onto stable sub-micron carrier particles and wherein sub-micronized particles are stabilized by additives having polar moieties, hydrophobic and hydrophilic segments. The sub-micron particles are selected from metal oxides like zinc oxide, titanium dioxide, cerium dioxide and silica, alumina, minerals, clays, stilbene and sub-micron carbons. Exemplary biocides include carbamates, isothiazolones, pyrithione chelates and/or trizoles. Also disclosed is a process for preparing stabilized sub- micronized carrier particles.

Abstract translation: 一种稳定的杀生物分散体，其包含涂覆或吸附在稳定的亚微米载体颗粒上的杀生物剂，并且其中亚微粉化颗粒通过具有极性部分，疏水和亲水链段的添加剂稳定。 亚微米颗粒选自金属氧化物如氧化锌，二氧化钛，二氧化铈和二氧化硅，氧化铝，矿物质，粘土，二苯乙烯和亚微米级的碳。 示例性杀生物剂包括氨基甲酸酯，异噻唑啉酮，吡啶硫酮螯合物和/或三唑。 还公开了制备稳定的亚微米粉末载体颗粒的方法。

公开(公告)号：WO2009121061A1

公开(公告)日：2009-10-01

申请号：PCT/US2009/038793

申请日：2009-03-30

Applicant: ISP INVESTMENTS INC. ,  PREMACHANDRAN, Raman ,  GOMEZ, Blanca ,  NARAYANAN, Kolazi, S. ,  WINKOWSKI, Karen

Inventor： PREMACHANDRAN, Raman ,  GOMEZ, Blanca ,  NARAYANAN, Kolazi, S. ,  WINKOWSKI, Karen

IPC: B01F3/00

CPC classification number: A01N25/04 ,  B01F17/0028 ,  B01F17/0092 ,  A01N25/30 ,  A01N47/12

Abstract: This invention provides a process of making a stable aqueous dispersion including concentrated, finely divided particles of a water insoluble biocide active, which comprises grinding the biocide in water in the presence of a non-ionic polymeric dispersant and optionally a co-dispersant, and compositions prepared by this process.

Abstract translation: 本发明提供了一种制备稳定的水分散体的方法，其包括浓缩的，细分散的水不溶性杀生物剂活性颗粒，其包括在非离子聚合物分散剂和任选的共分散剂的存在下，在水中研磨杀生物剂，以及组合物 通过这个过程准备。

公开(公告)号：WO2010148158A1

公开(公告)日：2010-12-23

申请号：PCT/US2010/038925

申请日：2010-06-17

Applicant: ISP INVESTMENTS INC. ,  PREMACHANDRAN, Raman ,  NARAYANAN, Kolazi, S. ,  GOMEZ, Blanca ,  WINKOWSKI, Karen ,  BROWN, Daniel, H.

Inventor： PREMACHANDRAN, Raman ,  NARAYANAN, Kolazi, S. ,  GOMEZ, Blanca ,  WINKOWSKI, Karen ,  BROWN, Daniel, H.

IPC: A01N25/28

CPC classification number: A01N25/04 ,  A01N25/08 ,  A01N25/12 ,  A01N47/04 ,  A01N47/12 ,  A01N59/16 ,  C09D5/1612 ,  C09D5/1687 ,  A01N43/80 ,  A01N43/70 ,  A01N47/30 ,  A01N2300/00

Abstract: Disclosed herein is a process for the preparation of a stable sustained-release biocidal composition containing microencapsulated biocide and wherein the process comprises the steps of: (i) adsorbing the biocide onto an inert carrier by grinding to attain the required particle size and wherein the ratio of biocide; inert carrier is in the range of about 1:99 to about 99:1 (ii) optionally coating with an appropriate amine or imine compound or a water resistant film forming polymer and dispersing the resultant biocide encapsulated inert carrier in an aqueous medium in the presence of suitable dispersing agent (iii) adding at least one thickening agent to re-disperse the encapsulated biocide containing partial amount of non-encapsulated biocide if any and (iv) preparing an aqueous or solvent based sustained release biocide dispersion. Also disclosed is a stable, sustained-release biocidal composition prepared by such process and uses thereof.

Abstract translation: 本文公开了一种制备含有微囊化杀生物剂的稳定的缓释杀生物组合物的方法，其中该方法包括以下步骤：（i）通过研磨将杀生物剂吸附到惰性载体上以达到所需的粒度， 的杀菌剂; 惰性载体在约1:99至约99:1的范围内（ii）任选用合适的胺或亚胺化合物或防水成膜聚合物涂覆，并将所得的杀生物剂包封的惰性载体在存在的水性介质中分散 （iii）加入至少一种增稠剂以重新分散含有部分量的未包封的杀生物剂的包封的杀生物剂，如果有的话，以及（iv）制备基于水性或溶剂的缓释杀生物剂分散体。 还公开了通过其方法和用途制备的稳定的缓释杀生物组合物。

公开(公告)号：WO2006041506A2

公开(公告)日：2006-04-20

申请号：PCT/US2005/000825

申请日：2005-01-10

Applicant: ISP INVESTMENTS INC. ,  BERTZ, Steven, H. ,  OROFINO, Steven, A. ,  BOTSCHKA, Ellen, S. ,  GOMEZ, Blanca ,  GORCEA, Mihaela ,  MAKAROVSKY, Ilya ,  LAURA, Donna, N.

Inventor： BERTZ, Steven, H. ,  OROFINO, Steven, A. ,  BOTSCHKA, Ellen, S. ,  GOMEZ, Blanca ,  GORCEA, Mihaela ,  MAKAROVSKY, Ilya ,  LAURA, Donna, N.

IPC: A61K8/39 ,  C09G1/02

CPC classification number: A61K8/37 ,  A61K8/0229 ,  A61Q1/06 ,  A61Q5/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/08 ,  C07C67/03 ,  C07C67/08 ,  C09G1/06 ,  C07C69/78 ,  C07C69/80 ,  C07C69/76

Abstract: An active or functional organic compound is solubilized in a diaryl organic compound having a polar or polarizable functional group therein, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include those present in personal care products, e.g., sunscreens containing UVA/UVB absorbing compounds, such as avobenzone, benzophenone-3, and 4-methylbenzylidene camphor. Such compositions also show increased SPF, UVA/UVB absorbance ratio, and critical wavelength performance properties.

Abstract translation: 活性或功能性有机化合物溶解在其中具有极性或可极化官能团的二芳基有机化合物中，作为溶剂，共溶剂或添加剂，以形成其组合物。 代表性的活性或功能性有机化合物包括存在于个人护理产品中的那些，例如含有UVA / UVB吸收化合物的防晒剂，例如阿伏苯宗，二苯甲酮-3和4-甲基亚苄基樟脑。 这些组合物还显示增加的SPF，UVA / UVB吸光度比和临界波长性能。

公开(公告)号：WO2011071876A1

公开(公告)日：2011-06-16

申请号：PCT/US2010/059227

申请日：2010-12-07

Applicant: ISP INVESTMENTS INC. ,  PREMACHANDRAN, Raman ,  BROWN, Daniel, H. ,  GOMEZ, Blanca ,  WINKOWSKI, Karen

Inventor： PREMACHANDRAN, Raman ,  BROWN, Daniel, H. ,  GOMEZ, Blanca ,  WINKOWSKI, Karen

IPC: A01N43/38 ,  A61K31/40

CPC classification number: A01N47/12 ,  A01N47/04 ,  A01N25/04 ,  A01N25/08 ,  A01N25/26 ,  A01N2300/00

Abstract: An aqueous dispersion having a mixture of a hydrolysis-sensitive biocide, an iodo- derived hydrophobic biocide and an inert carrier dispersed in water. The iodo-derived hydrophobic biocide forms a complex with the inert carrier and the hydrolysis-sensitive biocide that is dispersible in water. The hydrophobic coating includes an inert carrier and the hydrolysis-sensitive biocide may be trihalogenomethylthio phthalimide or an analogue thereof and the iodo-derived hydrophobic biocide may be iodopropynyl butylcarbamate. The aqueous dispersion may also include a water-repelling layer coating the complex.

Abstract translation: 具有水解敏感性杀生物剂，碘衍生的疏水性杀生物剂和分散在水中的惰性载体的混合物的水分散体。 碘衍生的疏水性杀生物剂与惰性载体和可分散在水中的水解敏感性杀生物剂形成络合物。 疏水性涂层包括惰性载体，水解敏感性杀生物剂可以是三卤甲基硫代邻苯二甲酰亚胺或其类似物，碘衍生的疏水性杀生物剂可以是碘代丙炔基丁基氨基甲酸酯。 水分散体还可以包括涂覆复合物的防水层。

公开(公告)号：WO2006041506A3

公开(公告)日：2007-12-21

申请号：PCT/US2005000825

申请日：2005-01-10

Applicant: ISP INVESTMENTS INC ,  BERTZ STEVEN H ,  OROFINO STEVEN A ,  BOTSCHKA ELLEN S ,  GOMEZ BLANCA ,  GORCEA MIHAELA ,  MAKAROVSKY ILYA ,  LAURA DONNA N

Inventor： BERTZ STEVEN H ,  OROFINO STEVEN A ,  BOTSCHKA ELLEN S ,  GOMEZ BLANCA ,  GORCEA MIHAELA ,  MAKAROVSKY ILYA ,  LAURA DONNA N

IPC: A61K8/00 ,  A61K8/02 ,  A61K8/04 ,  A61K8/06 ,  A61K8/37 ,  A61Q15/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  C07C67/03 ,  C07C67/08

CPC classification number: A61K8/37 ,  A61K8/0229 ,  A61Q1/06 ,  A61Q5/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/08 ,  C07C67/03 ,  C07C67/08 ,  C09G1/06 ,  C07C69/78 ,  C07C69/80 ,  C07C69/76

Abstract: An active or functional organic compound is solubilized in a diaryl organic compound having a polar or polarizable functional group therein, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include those present in personal care products, e.g., sunscreens containing UVA/UVB absorbing compounds, such as avobenzone, benzophenone-3, and 4-methylbenzylidene camphor. Such compositions also show increased SPF, UVA/UVB absorbance ratio, and critical wavelength performance properties.

Abstract translation: 活性或功能性有机化合物溶解在其中具有极性或可极化官能团的二芳基有机化合物中，作为溶剂，共溶剂或添加剂，以形成其组合物。 代表性的活性或功能性有机化合物包括存在于个人护理产品中的那些，例如含有UVA / UVB吸收化合物的防晒剂，例如阿伏苯宗，二苯甲酮-3和4-甲基亚苄基樟脑。 这些组合物还显示增加的SPF，UVA / UVB吸光度比和临界波长性能。