公开(公告)号：WO2009137832A2

公开(公告)日：2009-11-12

申请号：PCT/US2009/043460

申请日：2009-05-11

Applicant: DUKE UNIVERSITY ,  PATZ, Edward, F., Jr. ,  CAMPA, Michael, J. ,  GOTTLIN, Elizabeth, B.

Inventor： PATZ, Edward, F., Jr. ,  CAMPA, Michael, J. ,  GOTTLIN, Elizabeth, B.

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/53 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/40 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/734 ,  C07K2317/76 ,  G01N33/574

Abstract: Methods, kits, and compositions for detecting and/or treating cancer based on detecting and/or administering an antibody, which can optionally be a bispecific antibody, having the immunoreaction characteristics of a cancer-associated autoantibody; an antigen for a cancer-associated autoantibody; or both an antibody having the immunoreaction characteristics of a cancer-associated autoantibody and an antigen for a cancer-associated autoantibody, in or to a subject in need thereof.

Abstract translation: 用于检测和/或治疗癌症的方法，试剂盒和组合物，其基于检测和/或施用具有癌症相关自身抗体免疫反应特征的抗体（其可任选地是双特异性抗体）; 用于癌症相关自身抗体的抗原; 或具有癌症相关的自身抗体的免疫反应特性的抗体和癌症相关的自身抗体的抗原，或在有需要的受试者中。

公开(公告)号：WO2009137832A3

公开(公告)日：2010-04-01

申请号：PCT/US2009043460

申请日：2009-05-11

Applicant: UNIV DUKE ,  PATZ EDWARD F JR ,  CAMPA MICHAEL J ,  GOTTLIN ELIZABETH B

Inventor： PATZ EDWARD F JR ,  CAMPA MICHAEL J ,  GOTTLIN ELIZABETH B

IPC: G01N33/574 ,  A61K39/395 ,  G01N33/53 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/40 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/734 ,  C07K2317/76 ,  G01N33/574

Abstract: Methods, kits, and compositions for detecting and/or treating cancer based on detecting and/or administering an antibody, which can optionally be a bispecific antibody, having the immunoreaction characteristics of a cancer-associated autoantibody; an antigen for a cancer-associated autoantibody; or both an antibody having the immunoreaction characteristics of a cancer-associated autoantibody and an antigen for a cancer-associated autoantibody, in or to a subject in need thereof.

Abstract translation: 用于检测和/或治疗癌症的方法，试剂盒和组合物，其基于检测和/或施用具有癌症相关自身抗体免疫反应特征的抗体（其可任选地是双特异性抗体）; 用于癌症相关自身抗体的抗原; 或具有癌症相关的自身抗体的免疫反应特性的抗体和癌症相关的自身抗体的抗原，或在有需要的受试者中。

公开(公告)号：WO2010042815A3

公开(公告)日：2010-04-15

申请号：PCT/US2009/060159

申请日：2009-10-09

Applicant: DUKE UNIVERSITY ,  PATZ, Edward, F., Jr. ,  GOTTLIN, Elizabeth, B. ,  CAMPA, Michael, J.

Inventor： PATZ, Edward, F., Jr. ,  GOTTLIN, Elizabeth, B. ,  CAMPA, Michael, J.

IPC: G01N33/574 ,  G01N33/563 ,  C07K16/32

Abstract: The presently disclosed subject matter provides ligands for detecting and imaging cancer cells and tumors, and for guided delivery of an active agent to cancer cells and tumors. In some embodiments the ligands comprise an antibody fragment, wherein the antibody fragment comprises a VHH domain. In some embodiments a composition is provided for targeting of cancer cells or tumors. Also provided are methods for delivery of a composition to a target tissue or tumor in a subject. Also provided are methods for imaging a target tissue or tumor in a subject. In some embodiments methods for treating a tumor in a subject are provided. Also provided are methods for diagnosing a tumor in a subject.

公开(公告)号：WO2010042815A2

公开(公告)日：2010-04-15

申请号：PCT/US2009060159

申请日：2009-10-09

Applicant: UNIV DUKE ,  PATZ EDWARD F JR ,  GOTTLIN ELIZABETH B ,  CAMPA MICHAEL J

Inventor： PATZ EDWARD F JR ,  GOTTLIN ELIZABETH B ,  CAMPA MICHAEL J

IPC: G01N33/574 ,  C07K16/32 ,  G01N33/563

CPC classification number: C07K16/2863 ,  A61K51/103 ,  C07K2317/22 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  G01N33/57492

Abstract: The presently disclosed subject matter provides ligands for detecting and imaging cancer cells and tumors, and for guided delivery of an active agent to cancer cells and tumors. In some embodiments the ligands comprise an antibody fragment, wherein the antibody fragment comprises a VHH domain. In some embodiments a composition is provided for targeting of cancer cells or tumors. Also provided are methods for delivery of a composition to a target tissue or tumor in a subject. Also provided are methods for imaging a target tissue or tumor in a subject. In some embodiments methods for treating a tumor in a subject are provided. Also provided are methods for diagnosing a tumor in a subject.

Abstract translation: 本发明公开的主题提供了用于检测和成像癌细胞和肿瘤以及用于将活性剂引导递送至癌细胞和肿瘤的配体。 在一些实施方案中，配体包含抗体片段，其中抗体片段包含VHH结构域。 在一些实施方案中，提供用于靶向癌细胞或肿瘤的组合物。 还提供了用于将组合物递送至受试者中的靶组织或肿瘤的方法。 还提供了用于对受试者中的靶组织或肿瘤进行成像的方法。 在一些实施方式中，提供了用于治疗受试者中的肿瘤的方法。 还提供了用于诊断受试者中的肿瘤的方法。