公开(公告)号：WO2017079473A1

公开(公告)日：2017-05-11

申请号：PCT/US2016/060383

申请日：2016-11-03

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： YU, Paul, B. ,  DICARLI, Marcelo

IPC: A61B3/16 ,  A61K51/00 ,  A61K39/395 ,  A61K39/00 ,  C07K16/00

CPC classification number: A61K51/103 ,  A61B6/032 ,  A61B6/037 ,  C07K16/22

Abstract: A method of detecting a disease associated with pulmonary vascular remodeling. The method includes administering a radioisotope-conjugated antibody against vascular endothelial growth factor (VEGF). The method further includes imaging said antibody using positron emission tomography (PET), computed tomography (CT), or magnetic resonance imaging (MIR). Retention of said antibody reflects vascular remodeling.

Abstract translation: 检测与肺血管重塑有关的疾病的方法。 该方法包括施用抗血管内皮生长因子（VEGF）的放射性同位素缀合的抗体。 该方法还包括使用正电子发射断层摄影术（PET），计算机断层摄影术（CT）或磁共振成像（MIR）对所述抗体进行成像。 所述抗体的保留反映血管重塑。

公开(公告)号：WO2016020791A1

公开(公告)日：2016-02-11

申请号：PCT/IB2015/055678

申请日：2015-07-27

Applicant: NOVARTIS AG ,  ABRAMS, Tinya ,  COHEN, Steven Bruce ,  DANIEL, Dylan ,  FINNER, Catrin ,  GEIERSTANGER, Bernhard Hubert ,  HUBER, Thomas ,  MALLET, William ,  MEYER, Matthew John ,  OU, Weijia ,  SCHLEYER, Siew Ho ,  TISSOT-DAGUETTE, Kathrin Ulrike

Inventor： ABRAMS, Tinya ,  COHEN, Steven Bruce ,  DANIEL, Dylan ,  FINNER, Catrin ,  GEIERSTANGER, Bernhard Hubert ,  HUBER, Thomas ,  MALLET, William ,  MEYER, Matthew John ,  OU, Weijia ,  SCHLEYER, Siew Ho ,  TISSOT-DAGUETTE, Kathrin Ulrike

IPC: A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  C07K16/28

CPC classification number: A61K47/6803 ,  A61K39/39558 ,  A61K47/6849 ,  A61K49/00 ,  A61K51/103 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2039/545 ,  A61P35/02 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract translation: 本发明涉及抗cKIT抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。

公开(公告)号：WO2011041319A2

公开(公告)日：2011-04-07

申请号：PCT/US2010/050559

申请日：2010-09-28

Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH ,  OLD, Lloyd, J. ,  JOHNS, Terrance, Grant ,  PANOUSIS, Con ,  SCOTT, Andrew, Mark ,  RENNER, Christoph ,  JUNGBLUTH, Achim ,  STOCKERT, Elizabeth ,  COLLINS, Peter ,  CAVENEE, Webster, K. ,  HUANG, Huei-Jen, Su ,  BURGESS, Antony, Wilks ,  NICE, Edouard, Collins ,  MURRAY, Anne ,  MARK, George ,  RITTER, Gerd

Inventor： OLD, Lloyd, J. ,  JOHNS, Terrance, Grant ,  PANOUSIS, Con ,  SCOTT, Andrew, Mark ,  RENNER, Christoph ,  JUNGBLUTH, Achim ,  STOCKERT, Elizabeth ,  COLLINS, Peter ,  CAVENEE, Webster, K. ,  HUANG, Huei-Jen, Su ,  BURGESS, Antony, Wilks ,  NICE, Edouard, Collins ,  MURRAY, Anne ,  MARK, George ,  RITTER, Gerd

IPC: A61K51/10

CPC classification number: C07K16/2863 ,  A61K39/39558 ,  A61K51/103 ,  A61K51/1045 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/30 ,  C07K16/4266 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2300/00

Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract translation: 本发明涉及结合扩增的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的特异性结合成员，特别是抗体及其片段。 特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。 这些特异性结合成员可用于癌症的诊断和治疗。 本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。

公开(公告)号：WO2005005615A3

公开(公告)日：2007-06-21

申请号：PCT/US2004022068

申请日：2004-07-08

Applicant: FOX CHASE CANCER CT ,  ADAMS GREGORY P ,  SIMMONS HEIDI H ,  YUAN QING-AN ,  MARASCO WAYNE ,  MEHTA SMITA

Inventor： ADAMS GREGORY P ,  SIMMONS HEIDI H ,  YUAN QING-AN ,  MARASCO WAYNE ,  MEHTA SMITA

IPC: C07K16/00 ,  A61K39/00 ,  C07K14/00 ,  C07K16/28 ,  C07K16/30 ,  C12N20060101 ,  C12N5/10 ,  C12N15/00

CPC classification number: C07K16/2869 ,  A61K51/103 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73

Abstract: Compositions and methods for detecting and treating cancers expressing Mullerian inhibiting substance Type II receptor (MISIIR) are provided.

Abstract translation: 提供了用于检测和治疗表达穆勒抑制物质II型受体（MISIIR）的癌症的组合物和方法。

公开(公告)号：WO2002087497A2

公开(公告)日：2002-11-07

申请号：PCT/US2002/012502

申请日：2002-04-19

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： LI, Chun ,  VEGA, Javier, O. ,  KE, Shi ,  WALLACE, Sidney

IPC: A61K

CPC classification number: A61K51/1093 ,  A61K47/65 ,  A61K47/6889 ,  A61K51/103

Abstract: Conjugate molecules comprising a ligand or targeting moiety bonded to a polymer spacer, a polymer carrier bonded to the polymer spacer, and a therapeutic agent bound to the polymer carrier (with or without a linker) are disclosed. The conjugate molecules are useful for the selective delivery of therapeutic agents to tumors or other tissues expressing biological receptors.

Abstract translation: 公开了包含与聚合物间隔基结合的配体或靶向部分的结合物分子，与聚合物间隔基结合的聚合物载体和与聚合物载体结合的治疗剂（具有或不具有连接体）。 缀合物分子可用于将治疗剂选择性递送至表达生物受体的肿瘤或其他组织。

公开(公告)号：WO2016124781A1

公开(公告)日：2016-08-11

申请号：PCT/EP2016/052578

申请日：2016-02-05

Applicant: ABLYNX N.V.

Inventor： BOUTTON, Carlo ,  JANSSENS, Daniel ,  CASTEELS, Peter ,  SCHOTTE, Peter ,  DESCAMPS, Francis

IPC: C07K16/00 ,  A61K47/48 ,  A61P35/00 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/00 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  A61K51/103 ,  A61K51/1045 ,  C07K16/18 ,  C07K16/244 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/3007 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/60 ,  C07K2317/77

Abstract: The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain ( ISVD) and a C-terminal extension com prising a cysteine moiety (preferably at the C- terminus), wherein said first polypeptide and said second polypeptide are covalently linked via a disulfide bond between the cysteine moiety of said first polypeptide and the cysteine moiety of said second polypeptide, in which the dimer outperformed the benchmark constructs, e.g. cognate multivalent and multispecific constructs, in various assays. The present invention provides methods for making the dimers of the invention.

Abstract translation: 本发明涉及包含第一多肽和第二多肽的二聚体，其中所述第一和第二多肽中的每一个包含至少一个免疫球蛋白单可变结构域（ISVD）和半胱氨酸部分的C末端延伸（优选在C - 末端），其中所述第一多肽和所述第二多肽通过所述第一多肽的半胱氨酸部分和所述第二多肽的半胱氨酸部分之间的二硫键共价连接，其中二聚体优于基准构建体，例如 在多种测定中，同源多价和多特异性构建体。 本发明提供了制备本发明的二聚体的方法。

公开(公告)号：WO2014085821A2

公开(公告)日：2014-06-05

申请号：PCT/US2013/072668

申请日：2013-12-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： WU, Anna, M. ,  LI, Keyu

IPC: A47L13/257 ,  A47L13/60

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/48561 ,  A61K47/6849 ,  A61K51/103 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57423 ,  G01N2333/71 ,  G01N2333/91205

Abstract: Human antibody fragments against c-Met have been identified through phage display technology. The high affinity and low immunogenicity make them very useful for both in vivo and in vitro applications. These novel human antibodies can greatly help the study of drug resistance in EGFR targeted therapies, and improve the diagnosis and treatment of cancer patients.

Abstract translation: 已经通过噬菌体展示技术鉴定了针对c-Met的人抗体片段。 高亲和力和低免疫原性使其对于体内和体外应用都非常有用。 这些新的人类抗体可以极大地帮助研究EGFR靶向治疗药物的耐药性，并改善癌症患者的诊断和治疗。

公开(公告)号：WO2010096434A3

公开(公告)日：2011-01-27

申请号：PCT/US2010024407

申请日：2010-02-17

Applicant: LUDWIG INST CANCER RES ,  OLD LLOYD J ,  JONHS TERRANCE GRANT ,  PANOUSIS CON ,  SCOTT ANDREW MARK ,  RENNER CHRISTOPH ,  RITTER GERD ,  JUNGBLUTH ACHIM ,  STOCKERT ELIZABETH ,  COLLINS PETER ,  CAVENEE WEBSTER K ,  HUANG HUEI-JEN SU ,  BURGESS ANTONY WILKS ,  NICE EDOUARD COLLINS ,  MURRAY ANNE ,  MARK GEORGE

Inventor： OLD LLOYD J ,  JONHS TERRANCE GRANT ,  PANOUSIS CON ,  SCOTT ANDREW MARK ,  RENNER CHRISTOPH ,  RITTER GERD ,  JUNGBLUTH ACHIM ,  STOCKERT ELIZABETH ,  COLLINS PETER ,  CAVENEE WEBSTER K ,  HUANG HUEI-JEN SU ,  BURGESS ANTONY WILKS ,  NICE EDOUARD COLLINS ,  MURRAY ANNE ,  MARK GEORGE

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  G01N33/50 ,  G01N33/574

CPC classification number: C07K16/40 ,  A61K31/495 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/6871 ,  A61K51/103 ,  A61K51/1045 ,  A61K51/1078 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/4258 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  A61K2300/00

Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

公开(公告)号：WO2010042815A2

公开(公告)日：2010-04-15

申请号：PCT/US2009060159

申请日：2009-10-09

Applicant: UNIV DUKE ,  PATZ EDWARD F JR ,  GOTTLIN ELIZABETH B ,  CAMPA MICHAEL J

Inventor： PATZ EDWARD F JR ,  GOTTLIN ELIZABETH B ,  CAMPA MICHAEL J

IPC: G01N33/574 ,  C07K16/32 ,  G01N33/563

CPC classification number: C07K16/2863 ,  A61K51/103 ,  C07K2317/22 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  G01N33/57492

Abstract: The presently disclosed subject matter provides ligands for detecting and imaging cancer cells and tumors, and for guided delivery of an active agent to cancer cells and tumors. In some embodiments the ligands comprise an antibody fragment, wherein the antibody fragment comprises a VHH domain. In some embodiments a composition is provided for targeting of cancer cells or tumors. Also provided are methods for delivery of a composition to a target tissue or tumor in a subject. Also provided are methods for imaging a target tissue or tumor in a subject. In some embodiments methods for treating a tumor in a subject are provided. Also provided are methods for diagnosing a tumor in a subject.

Abstract translation: 本发明公开的主题提供了用于检测和成像癌细胞和肿瘤以及用于将活性剂引导递送至癌细胞和肿瘤的配体。 在一些实施方案中，配体包含抗体片段，其中抗体片段包含VHH结构域。 在一些实施方案中，提供用于靶向癌细胞或肿瘤的组合物。 还提供了用于将组合物递送至受试者中的靶组织或肿瘤的方法。 还提供了用于对受试者中的靶组织或肿瘤进行成像的方法。 在一些实施方式中，提供了用于治疗受试者中的肿瘤的方法。 还提供了用于诊断受试者中的肿瘤的方法。

公开(公告)号：WO2009039207A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076722

申请日：2008-09-17

Applicant: ONCOFLUOR, INC. ,  LUIKEN, George, A.

Inventor： LUIKEN, George, A.

IPC: A61B5/00 ,  A61K51/00

CPC classification number: A61B5/417 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B6/037 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/005 ,  A61K51/0406 ,  A61K51/0491 ,  A61K51/083 ,  A61K51/088 ,  A61K51/103 ,  A61K51/1036 ,  A61K51/1048 ,  A61K51/1051 ,  A61K51/1054 ,  A61K51/1063 ,  A61K51/1072

Abstract: The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.

Abstract translation: 本发明提供用于检测和治疗哺乳动物的恶性组织，器官或细胞的方法和组合物。 该方法包括在一个基因组或通过提供对组织或器官的进入的途径中肠胃外注射哺乳动物受试者，该组合物包含用荧光团和治疗同位素分子标记的抗体/片段的组合物，其特异性结合靶向 器官，组织或细胞。