中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

12 records (took 0.024 seconds)

    CHIMERIC FACTOR H BINDING PROTEINS (FHBP) AND METHODS OF USE
    4.
    发明申请
    CHIMERIC FACTOR H BINDING PROTEINS (FHBP) AND METHODS OF USE 审中-公开
    CHIMERIC因子H结合蛋白（FHBP）及其使用方法

    公开(公告)号：WO2010127172A3

    公开(公告)日：2012-10-04

    申请号：PCT/US2010033048

    申请日：2010-04-29

    Applicant: CHILDRENS HOSP & RES CT OAK ,  GRANOFF DAN M ,  BEERNINK PETER ,  NOVARTIS VACCINES & DIAGNOSTIC

    Inventor： GRANOFF DAN M ,  BEERNINK PETER

    IPC: A61K39/02 ,  A61K39/00 ,  A61K39/095 ,  A61K39/116

    CPC classification number: A61K39/095 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/22 ,  C07K16/1217 ,  C07K2317/34 ,  C12N15/74

    Abstract: Provided are chimeric factor H binding proteins (fHbps) that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use fHbps. More specifically, the disclosure provides unique sequences in fHbp variable segment A through E, each assigned with a unique identifier beginning with a letter, A through E, to represent the segment. Further disclosed are chimeric fHbps including operably linked amino acid sequences derived from different variants. Methods of using the fHbps for treating Neisseria infection, especially N. meningitidis, are further disclosed.

    Abstract translation: 提供可以引发针对脑膜炎奈瑟氏球菌的不同fHbp变体菌株杀菌的抗体的嵌合因子H结合蛋白（fHbps）和使用fHbps的方法。 更具体地，本公开提供了fHbp可变段A至E中的唯一序列，每个分配有以字母A至E开头的唯一标识符来表示段。 进一步公开的是嵌合fHbps，包括衍生自不同变体的可操作地连接的氨基酸序列。 进一步公开了使用fHbps治疗奈瑟氏球菌感染，特别是脑膜炎奈瑟氏球菌的方法。

    POLYSACCHARIDE DERIVATIVES AND USES IN INDUCTION OF AN IMMUNE RESPONSE
    5.
    发明申请
    POLYSACCHARIDE DERIVATIVES AND USES IN INDUCTION OF AN IMMUNE RESPONSE 审中-公开
    多糖衍生物和诱导免疫应答的用途

    公开(公告)号：WO2006002402A2

    公开(公告)日：2006-01-05

    申请号：PCT/US2005/022590

    申请日：2005-06-23

    Applicant: CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND ,  MOE, Gregory, R. ,  GRANOFF, Dan, M.

    Inventor： MOE, Gregory, R. ,  GRANOFF, Dan, M.

    IPC: C08B37/00

    CPC classification number: C08L5/00 ,  A61K39/0258 ,  A61K39/095 ,  A61K2039/6037 ,  C08B37/0063 ,  Y02A50/474

    Abstract: The present invention generally provides compositions comprising a polysaccharide derivative, and methods of their preparation and use for the prevention or treatment of diseases caused by Neisseria meningitidis bacteria, particularly group B (NmB) strains, and by E . coli K1. The invention provides a de-N-acetylated PS derivative in which one or more residues of the PS has been modified by de-N-acetylation. The invention also includes derivatives in which one or more of the N-acetyl groups of PS containing de-N-acetylated PS are replaced with other N-acyl groups, usually a lower acyl group of C 2 - C 3 . Further, the invention includes de-N-acetylated PS derivatives containing long chain hydrocarbons, as well as conjugates in which the de-N-acetylated PS derivative is linked to a carrier, e.g., a carrier protein.

    Abstract translation: 本发明通常提供包含多糖衍生物的组合物及其制备和用途的方法，用于预防或治疗脑膜炎奈瑟菌，尤其是B组（NmB）菌株和大肠杆菌K1引起的疾病。 本发明提供了脱-N-乙酰化的PS衍生物，其中PS的一个或多个残基已被去N-乙酰化修饰。 本发明还包括衍生物，其中含有脱-N-乙酰化PS的PS的一个或多个N-乙酰基被其它N-酰基取代，通常为C 2 - ç 3 。 此外，本发明包括含有长链烃的脱-N-乙酰化PS衍生物，以及其中脱-N-乙酰化PS衍生物与载体例如载体蛋白连接的缀合物。

Patent Agency Ranking