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    PEPTIDE VACCINES COMPRISING SELF-ASSEMBLING POLYMER NANOPARTICLES
    6.
    发明申请
    PEPTIDE VACCINES COMPRISING SELF-ASSEMBLING POLYMER NANOPARTICLES 审中-公开
    包含自组装聚合物纳米颗粒的肽疫苗

    公开(公告)号：WO2017147597A1

    公开(公告)日：2017-08-31

    申请号：PCT/US2017/019748

    申请日：2017-02-27

    申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

    发明人： SEDER, Robert ,  LYNN, Geoffrey

    IPC分类号： A61K39/00 ,  A61K39/39

    CPC分类号： A61K39/0011 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/60 ,  A61K2039/6093

    摘要： Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.

    摘要翻译： 提供了用于将肽抗原递送至受试者以诱导针对肽抗原的免疫应答的新型平台的实施方案。 例如，提供了包含通过静电相互作用与肽缀合物连接的聚合物的纳米粒子复合物。 缀合物包含通过任选的接头连接至肽标签的肽抗原。 纳米颗粒多聚复合物中可以包含佐剂，其与聚合物或缀合物连接，或者与纳米颗粒混合。 纳米颗粒多聚复合物可以施用于受试者以诱导针对肽抗原的免疫应答。

    CYTOTOXIC IMMUNOSTIMULATING PARTICLES AND USES THEREOF
    9.
    发明申请
    CYTOTOXIC IMMUNOSTIMULATING PARTICLES AND USES THEREOF 审中-公开

    公开(公告)号：WO2017067592A1

    公开(公告)日：2017-04-27

    申请号：PCT/EP2015/074386

    申请日：2015-10-21

    申请人： BIONTECH AG

    发明人： PASCOLO, Steve

    IPC分类号： A61K39/39

    CPC分类号： A61K39/39 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/572

    摘要： The present invention relates to particles comprising RNA, in which the RNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid, wherein the RNA comprises a cytotoxic nucleotide or cytotoxic nucleotide analog and/or the RNA is covalently attached to a cytotoxin, pharmaceutical compositions containing said particles and pharmaceutical uses of the particles and pharmaceutical compositions. The particles of the present invention are particularly useful as an immunostimulating medicament capable to block proliferation or induce death in dividing cells such as tumor cells.