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    NOVEL BIOACTIVE LIPID DERIVATIVES, IMMUNE-DERIVED MOIETIES REACTIVE THERETO, AND METHODS OF MAKING AND USING THE SAME
    3.
    发明申请
    NOVEL BIOACTIVE LIPID DERIVATIVES, IMMUNE-DERIVED MOIETIES REACTIVE THERETO, AND METHODS OF MAKING AND USING THE SAME 审中-公开
    新型生物脂质衍生物，免疫衍生物，反应物及其制备和使用方法

    公开(公告)号：WO2007140431A2

    公开(公告)日：2007-12-06

    申请号：PCT/US2007070013

    申请日：2007-05-31

    Applicant: LPATH INC ,  SABBADINI ROGER A ,  GARLAND WILLIAM A ,  HANSEN GENEVIEVE

    Inventor： SABBADINI ROGER A ,  GARLAND WILLIAM A ,  HANSEN GENEVIEVE

    IPC: G01N33/53 ,  C07K14/47 ,  C07K16/18 ,  C12P21/04

    CPC classification number: C07K16/00 ,  A61K47/544 ,  A61K47/60 ,  A61K47/643 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/3076 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2500/44 ,  G01N33/6854 ,  G01N33/92

    Abstract: Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1 -phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

    Abstract translation: 描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。 这些组合物包括衍生的脂质，其中每一种都包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已经用 吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅氧烷珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。 还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

    ORALLY DELIVERABLE AND ANTI-TOXIN ANTIBODIES AND METHODS FOR MAKING AND USING THEM
    4.
    发明申请
    ORALLY DELIVERABLE AND ANTI-TOXIN ANTIBODIES AND METHODS FOR MAKING AND USING THEM 审中-公开
    ORALLY可交付和抗毒素抗体及其制备和使用它们的方法

    公开(公告)号：WO2006071877A2

    公开(公告)日：2006-07-06

    申请号：PCT/US2005047100

    申请日：2005-12-22

    Applicant: DIVERSA CORP ,  HANSEN GENEVIEVE ,  DEMAREST STEPHEN J

    Inventor： HANSEN GENEVIEVE ,  DEMAREST STEPHEN J

    IPC: A61K39/395

    CPC classification number: C07K16/1282 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/50 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

    Abstract: The invention provides antibodies with superior therapeutic efficacy and related methods of engineering such antibodies to increase their stability and resistance to proteases, e.g., in the digestive tract. Protease cleavage motifs are identified and subsequently modified to reduce or eliminate cleavage at that site. Methods of employing these orally deliverable antibodies as therapeutic compositions, particularly against gastrointestinal pathogens are also provided herein. In one aspect, the invention provides combinations of monoclonal antibodies, e.g., "synthetic polyclonals", that work synergistically to neutralize bacterial toxins, particularly enteric bacterial toxins such as Clostridium difficile toxin A.

    Abstract translation: 本发明提供具有优良治疗功效的抗体和相关的工程技术，以增加其对蛋白酶（例如在消化道中）的稳定性和抗性。 鉴定蛋白酶切割基序并随后进行修饰以减少或消除该位点处的切割。 本文还提供了使用这些口服递送抗体作为治疗组合物，特别是胃肠道病原体的方法。 一方面，本发明提供了协同作用以中和细菌毒素，特别是肠道细菌毒素如艰难梭菌毒素A的单克隆抗体，例如“合成多克隆”的组合。

    MONOCLONAL ANTIBODIES DIRECTED TO CD20
    5.
    发明申请
    MONOCLONAL ANTIBODIES DIRECTED TO CD20 审中-公开
    针对CD20的单克隆抗体

    公开(公告)号：WO2011109108A1

    公开(公告)日：2011-09-09

    申请号：PCT/US2011/000415

    申请日：2011-03-04

    Applicant: VET THERAPEUTICS INC. ,  HANSEN, Genevieve

    Inventor： HANSEN, Genevieve

    IPC: A61K39/395 ,  C07K16/00

    CPC classification number: C07K16/2887 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/92

    Abstract: The invention provides antibody to canine or feline or equine antigens. Specifically, antibodies directed to canine CD20 which have been caninized or felinized are provided. Also provided are methods for preparing high affinity antibodies to canine and feline CD20 as well as methods for treating B cell disorders in companion animals.

    Abstract translation: 本发明提供针对犬或猫或马抗原的抗体。 具体地，提供了针对犬科CD20的已经被驯化或被熔化的抗体。 还提供了制备犬和猫CD20的高亲和力抗体的方法以及用于治疗伴侣动物的B细胞疾病的方法。

    ANTIBODY CONSTANT DOMAIN REGIONS AND USES THEREOF
    6.
    发明申请
    ANTIBODY CONSTANT DOMAIN REGIONS AND USES THEREOF 审中-公开
    抗体恒定区域及其用途

    公开(公告)号：WO2010110838A2

    公开(公告)日：2010-09-30

    申请号：PCT/US2010/000666

    申请日：2010-03-04

    Applicant: VET THERAPEUTICS INC. ,  HANSEN, Genevieve

    Inventor： HANSEN, Genevieve

    IPC: A61K39/395

    CPC classification number: C07K16/464 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/20 ,  C07K2317/52 ,  C07K2317/732 ,  C07K2317/734 ,  G01N33/6854

    Abstract: The invention provides recombinant protein (e.g., a recombinant antibody or soluble receptor) having (i) a binding domain capable of specific binding to an epitope (for example an antibody variable domains, a receptor, a growth factor, a cytokine, or a fragment of any of the foregoing which is capable of specifically binding the desired epitope) and (ii) an effector domain comprising a constant domain region which is derived from immunoglobulin of a first species which is a companion mammal, e.g. dog, cat, or horse, having engineered substitutions at one or more positions and having an altered interaction with one or more FcRs or other ligands, and optionally enhanced effector function, relative to the parent constant domain region.

    Abstract translation: 本发明提供重组蛋白（例如，重组抗体或可溶性受体），其具有（i）能够与表位特异性结合的结合结构域（例如抗体可变结构域，受体，生长因子，细胞因子或片段 能够特异性结合所需表位的任何前述物质）和（ii）包含源自免疫球蛋白的恒定结构域区域的效应结构域，所述第一物种是伴侣哺乳动物，例如 狗，猫或马，在一个或多个位置具有改造的取代并且与一个或多个FcR或其它配体具有改变的相互作用，以及相对于母体恒定域区域可选地增强的效应子功能。

    IMMUNE-DERIVED MOIETIES REACTIVE AGAINST LYSOPHOSPHATIDIC ACID
    7.
    发明申请
    IMMUNE-DERIVED MOIETIES REACTIVE AGAINST LYSOPHOSPHATIDIC ACID 审中-公开
    免疫衍生物对反应性物质的反应

    公开(公告)号：WO2007140434A2

    公开(公告)日：2007-12-06

    申请号：PCT/US2007070016

    申请日：2007-05-31

    Applicant: LPATH INC ,  SABBADINI ROGER A ,  GARLAND WILLIAM A ,  HANSEN GENEVIEVE

    Inventor： SABBADINI ROGER A ,  GARLAND WILLIAM A ,  HANSEN GENEVIEVE

    IPC: G01N33/53 ,  C07K14/47 ,  C07K16/18 ,  C12P21/04

    CPC classification number: G01N33/92 ,  A61K47/544 ,  A61K47/60 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/74

    Abstract: Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1 -phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

    Abstract translation: 描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。 这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已经用 吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。 还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

    METHODS AND REAGENTS FOR DETECTING BIOACTIVE LIPIDS
    8.
    发明申请
    METHODS AND REAGENTS FOR DETECTING BIOACTIVE LIPIDS 审中-公开
    检测生物活性脂肪酸的方法和试剂

    公开(公告)号：WO2007140433A2

    公开(公告)日：2007-12-06

    申请号：PCT/US2007/070015

    申请日：2007-05-31

    Applicant: LPATH, INC. ,  SABBADINI, Roger, A. ,  GARLAND, William, A. ,  HANSEN, Genevieve

    Inventor： SABBADINI, Roger, A. ,  GARLAND, William, A. ,  HANSEN, Genevieve

    IPC: G01N33/53 ,  C12P21/04 ,  C07K16/18 ,  C07K14/47

    CPC classification number: G01N33/92 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  G01N33/6854

    Abstract: Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1 -phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

    Abstract translation: 描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。 这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已经用 吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。 还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

    COMPOSITIONS AND METHODS FOR AMELIORATING TOXINS AND VIRULENCE FACTORS
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR AMELIORATING TOXINS AND VIRULENCE FACTORS 审中-公开

    公开(公告)号：WO2007061886A3

    公开(公告)日：2007-05-31

    申请号：PCT/US2006/044760

    申请日：2006-11-16

    Applicant: VERENIUM CORPORATION ,  DEMAREST, Stephen, J. ,  HANSEN, Genevieve

    Inventor： DEMAREST, Stephen, J. ,  HANSEN, Genevieve

    IPC: C12N15/00

    Abstract: The invention provides methods of ameliorating or preventing toxicity associated with a virulence factor or toxin (e.g., a microbial virulence factor, e.g., from Clostridium ) in a subject, comprising administering to the subject in need thereof, a therapeutically effective amount of polypeptide having a protease activity, e.g., an isolated, recombinant or synthetic protease or antibody having protease activity, wherein the polypeptide (e.g., protease) partially or completely neutralizes the virulence factor or a toxin, thereby ameliorating or preventing the toxicity associated with the virulence factor or toxin.

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