RECOMBINANT NONPATHOGENIC MDV VECTOR PROVIDING MULTIVALENT IMMUNITY
    6.
    发明申请
    RECOMBINANT NONPATHOGENIC MDV VECTOR PROVIDING MULTIVALENT IMMUNITY 审中-公开
    重组非致病性MDV载体提供多重免疫

    公开(公告)号:WO2013057235A1

    公开(公告)日:2013-04-25

    申请号:PCT/EP2012/070727

    申请日:2012-10-19

    IPC分类号: A61K39/17 A61K39/12

    摘要: The present invention relates to the field of veterinary vaccines, in particular to that of vector vaccines for poultry based on recombinant nonpathogenic Marek's disease virus (npMDV). The recombinant npMDV of the invention expresses stably and effectively two heterologous genes each originating from a different micro-organism: the fusion protein gene from Newcastle disease virus, and the viral protein 2 gene from infectious bursal disease virus. A vaccine based on this recombinant npMDV can be used to induce in poultry a protective immune response not only against Marek's disease, but also against Newcastle disease and Infectious bursal disease. The invention also relates to methods and uses involving the recombinant npMDV, expression cassette, infected host cells, and vaccines.

    摘要翻译: 本发明涉及兽医疫苗领域,特别涉及基于重组非致病性马立克氏病病毒(npMDV)的禽类载体疫苗领域。 本发明的重组npMDV稳定而有效地表达了两种来自不同微生物的异源基因:来自新城疫病毒的融合蛋白基因和来自传染性法氏囊病病毒的病毒蛋白2基因。 基于该重组npMDV的疫苗可用于在家禽中诱导不仅对马立克氏病的保护性免疫应答,而且还针对新城疫和传染性法氏囊病。 本发明还涉及涉及重组npMDV,表达盒,感染的宿主细胞和疫苗的方法和用途。