公开(公告)号：WO2003051831A3

公开(公告)日：2003-06-26

申请号：PCT/US2002/040001

申请日：2002-12-13

Applicant: PHARMACIA CORPORATION ,  GOETZ, Gilles, H. ,  HARRIGAN, George, G. ,  LIKOS, John, J. ,  KASTEN, Thomas, P.

Inventor： GOETZ, Gilles, H. ,  HARRIGAN, George, G. ,  LIKOS, John, J. ,  KASTEN, Thomas, P.

IPC: C07D209/02

Abstract: The present invention is directed toward a composition comprising a compound isolated from Dysidea species sponges that is capable of inhibiting serine proteases of the coagulation cascade. In particular, this composition inhibits the TF/VIIa complex of the coagulation cascade. The invention is also directed toward methods employing this composition as a part of anticoagulant therapy.

公开(公告)号：WO2003051831A2

公开(公告)日：2003-06-26

申请号：PCT/US2002/040001

申请日：2002-12-13

Applicant: PHARMACIA CORPORATION ,  GOETZ, Gilles, H. ,  HARRIGAN, George, G. ,  LIKOS, John, J. ,  KASTEN, Thomas, P.

Inventor： GOETZ, Gilles, H. ,  HARRIGAN, George, G. ,  LIKOS, John, J. ,  KASTEN, Thomas, P.

IPC: C07D

CPC classification number: C07D403/12

Abstract: The present invention is directed toward a composition comprising a compound isolated from Dysidea species sponges that is capable of inhibiting serine proteases of the coagulation cascade. In particular, this composition inhibits the TF/VIIa complex of the coagulation cascade. The invention is also directed toward methods employing this composition as a part of anticoagulant therapy.

Abstract translation: 本发明涉及包含从Dysidea物种海绵分离的化合物的组合物，其能够抑制凝血级联的丝氨酸蛋白酶。 特别是，该组合物抑制凝血级联的TF / VIIa复合物。 本发明还涉及使用该组合物作为抗凝血剂治疗的一部分的方法。