公开(公告)号：WO2010099526A1

公开(公告)日：2010-09-02

申请号：PCT/US2010/025737

申请日：2010-03-01

Applicant: SUNESIS PHARMACEUTICALS, INC. ,  HAWTIN, Rachael, E. ,  FOX, Judith, A.

Inventor： HAWTIN, Rachael, E. ,  FOX, Judith, A.

IPC: A61K31/045 ,  A61K31/4375 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/4375 ,  A61K31/045 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  A61K2300/00

Abstract: Methods of using SNS-595 for treatment of a subject having cancer with BRCA2 mutation are described. In certain embodiments, the methods comprise administering a therapeutically effective amount of SNS-595 to a subject in need thereof.

Abstract translation: 描述了使用SNS-595治疗具有BRCA2突变的癌症患者的方法。 在某些实施方案中，所述方法包括向有需要的受试者施用治疗有效量的SNS-595。

公开(公告)号：WO2014036040A2

公开(公告)日：2014-03-06

申请号：PCT/US2013056914

申请日：2013-08-27

Applicant: NODALITY INC ,  PTACEK JASON ,  EVENSEN ERIK ,  HAWTIN RACHAEL

Inventor： PTACEK JASON ,  EVENSEN ERIK ,  HAWTIN RACHAEL

IPC: G01N33/50

CPC classification number: G01N33/5091 ,  G01N33/50 ,  G01N33/5017 ,  G01N33/502 ,  G01N33/5041 ,  G01N33/5094 ,  G01N2800/24 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/60 ,  G01N2800/7028

Abstract: The invention provides methods, compositions, and systems for diagnosis, evaluation of status, and/or determination of treatment for pathological conditions.

Abstract translation: 本发明提供用于诊断，评估状态和/或病理状态治疗的确定的方法，组合物和系统。

公开(公告)号：WO2013188469A2

公开(公告)日：2013-12-19

申请号：PCT/US2013/045273

申请日：2013-06-11

Applicant: NODALITY, INC. ,  CESANO, Alessandra ,  ROSEN, David ,  FANTL, Wendy, J. ,  HAWTIN, Rachael

Inventor： CESANO, Alessandra ,  ROSEN, David ,  FANTL, Wendy, J. ,  HAWTIN, Rachael

IPC: G01N33/68

CPC classification number: G01N33/57415 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y301/02015 ,  G01N33/5011 ,  G01N33/505 ,  G01N33/57449 ,  G01N33/6875 ,  G01N33/6893 ,  G01N2333/9108 ,  G01N2510/00 ,  G01N2800/52

Abstract: The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.

Abstract translation: 本发明提供用于在含有遗传改变的细胞中表征细胞途径的方法，组合物和试剂盒。

公开(公告)号：WO2017123659A1

公开(公告)日：2017-07-20

申请号：PCT/US2017/013051

申请日：2017-01-11

Applicant: NODALITY, INC. ,  HOTSON, Andrew ,  HAWTIN, Rachael

Inventor： HOTSON, Andrew ,  HAWTIN, Rachael

IPC: A61K39/00 ,  A61P1/00 ,  A61P1/04

CPC classification number: G01N33/5091 ,  G01N33/5023 ,  G01N33/56972 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2800/52

Abstract: Disclosed herein are methods and compositions for determining the proclivity of immune cells to polarize to one or more immune cell subpopulations (e.g., Th17 population) and/or to produce one or more intracellular substances (e.g., after stimulation).

Abstract translation: 本文公开了用于确定免疫细胞极化至一个或多个免疫细胞亚群（例如Th17群）和/或产生一种或多种细胞内物质（例如，之后）的倾向性的方法和组合物 刺激）。

公开(公告)号：WO2013188469A3

公开(公告)日：2015-04-02

申请号：PCT/US2013045273

申请日：2013-06-11

Applicant: NODALITY INC ,  CESANO ALESSANDRA ,  ROSEN DAVID ,  FANTL WENDY J ,  HAWTIN RACHAEL

Inventor： CESANO ALESSANDRA ,  ROSEN DAVID ,  FANTL WENDY J ,  HAWTIN RACHAEL

IPC: C12Q1/68 ,  G01N33/566

CPC classification number: G01N33/57415 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y301/02015 ,  G01N33/5011 ,  G01N33/505 ,  G01N33/57449 ,  G01N33/6875 ,  G01N33/6893 ,  G01N2333/9108 ,  G01N2510/00 ,  G01N2800/52

Abstract: The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.

Abstract translation: 本发明提供用于在含有遗传改变的细胞中表征细胞途径的方法，组合物和试剂盒。

公开(公告)号：WO2014036040A3

公开(公告)日：2014-03-06

申请号：PCT/US2013/056914

申请日：2013-08-27

Applicant: NODALITY INC. ,  PTACEK, Jason ,  EVENSEN, Erik ,  HAWTIN, Rachael

Inventor： PTACEK, Jason ,  EVENSEN, Erik ,  HAWTIN, Rachael

IPC: C12Q1/02 ,  G01N33/53

Abstract: The invention provides methods, compositions, and systems for diagnosis, evaluation of status, and/or determination of treatment for pathological conditions.

公开(公告)号：WO2011056566A3

公开(公告)日：2011-06-30

申请号：PCT/US2010054086

申请日：2010-10-26

Applicant: SUNESIS PHARMACEUTICALS INC ,  SUDHAKAR ANANTHA ,  HAWTIN RACHAEL E ,  STOCKETT DAVID

Inventor： SUDHAKAR ANANTHA ,  HAWTIN RACHAEL E ,  STOCKETT DAVID

IPC: C07D471/04 ,  A61K31/4375 ,  A61P35/02

CPC classification number: C07D471/04

Abstract: Compounds for treating, preventing or managing cancer are disclosed. Also provided are methods for using the compounds in treatment of various cancers. Also provided are methods of treatment using the compounds together with another chemotherapy, radiation therapy, hormonal therapy, biological therapy, or immunotherapy. Pharmaceutical compositions suitable for use in the methods are also disclosed.

Abstract translation: 公开了用于治疗，预防或控制癌症的化合物。 还提供了使用这些化合物治疗各种癌症的方法。 还提供了将化合物与另一种化学疗法，放射疗法，激素疗法，生物疗法或免疫疗法一起使用的治疗方法。 也公开了适用于该方法的药物组合物。

公开(公告)号：WO2011056566A2

公开(公告)日：2011-05-12

申请号：PCT/US2010/054086

申请日：2010-10-26

Applicant: SUNESIS PHARMACEUTICALS, INC. ,  SUDHAKAR, Anantha ,  HAWTIN, Rachael, E. ,  STOCKETT, David

Inventor： SUDHAKAR, Anantha ,  HAWTIN, Rachael, E. ,  STOCKETT, David

IPC: C07D471/04 ,  A61K31/4375 ,  A61P35/02

CPC classification number: C07D471/04

Abstract: Compounds for treating, preventing or managing cancer are disclosed. Also provided are methods for using the compounds in treatment of various cancers. Also provided are methods of treatment using the compounds together with another chemotherapy, radiation therapy, hormonal therapy, biological therapy, or immunotherapy. Pharmaceutical compositions suitable for use in the methods are also disclosed.

Abstract translation: 公开了用于治疗，预防或控制癌症的化合物。 还提供了使用该化合物治疗各种癌症的方法。 还提供了使用化合物与另一种化学疗法，放射疗法，激素治疗，生物疗法或免疫治疗一起治疗的方法。 还公开了适用于该方法的药物组合物。