公开(公告)号：WO2011130528A1

公开(公告)日：2011-10-20

申请号：PCT/US2011/032519

申请日：2011-04-14

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC. ,  HO, Chih-Hu

Inventor： HO, Chih-Hu

IPC: B01D3/00 ,  B01D61/00 ,  C02F1/44

CPC classification number: A61M1/3672 ,  A61K31/722 ,  A61K31/734 ,  A61M1/16 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3437 ,  A61M1/3455 ,  A61M1/3458 ,  A61M1/36 ,  A61M1/3673 ,  A61M1/3675 ,  A61M1/3679 ,  B01D61/28 ,  B01D67/0093 ,  B01D71/68 ,  B01D71/76 ,  B01D2323/04 ,  B01D2323/30 ,  B01D2325/38 ,  C02F1/44

Abstract: An extracorporeal blood treatment system includes means for withdrawing blood from a patient, and means for transporting the blood through a calcium trap. The calcium trap includes a substrate having an immobilized species, the species being adapted to reduce the calcium concentration in the blood to a concentration that prevents blood clotting in the extracorporeal blood treatment system, thereby producing calcium-depleted blood. The extracorporeal blood treatment system also includes means for treating the calcium-depleted blood downstream of the calcium trap by an extracorporeal blood treatment device, thereby producing treated calcium- depleted blood, means for infusing calcium into the treated calcium-depleted blood downstream of the extracorporeal blood treatment device to add calcium to the treated calcium-depleted blood, and means for returning treated blood back to the patient.

Abstract translation: 体外血液处理系统包括用于从患者抽出血液的装置，以及用于通过钙离子阱运送血液的装置。 钙捕获器包括具有固定化物质的底物，该物质适于将血液中的钙浓度降低到防止体外血液处理系统中血液凝固的浓度，由此产生贫血的血液。 体外血液处理系统还包括通过体外血液处理装置处理钙捕获器下游的贫血的血液的手段，从而产生经过处理的贫血的血液，用于将钙注入体外下游的经处理的贫血的血液中的手段 血液处理装置，用于向经处理的贫血血液中加入钙，以及将处理过的血液返回给患者的装置。

公开(公告)号：WO2006019891A3

公开(公告)日：2006-02-23

申请号：PCT/US2005/024960

申请日：2005-07-14

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC. ,  HO, Chih-Hu ,  TUOMINEN, Olli ,  STROUP, Eric, W.

Inventor： HO, Chih-Hu ,  TUOMINEN, Olli ,  STROUP, Eric, W.

IPC: A61M37/00 ,  A61F2/00 ,  A61L33/00

Abstract: A blood tubing set such as an arterial-venous blood tubing set used in hemodialysis is coated with a copolymer having a hydrophobic segment and a hydrophilic segment. For example, the coating can be PEO-PPO-PEO triblock copolymer. The hydrophobic segment attaches to the tubing set, and the hydrophilic segment prevents or reduces unwanted sorption on the blood tubing set.

公开(公告)号：WO2006019891A2

公开(公告)日：2006-02-23

申请号：PCT/US2005024960

申请日：2005-07-14

Applicant: FRESENIUS MED CARE HLDG INC ,  HO CHIH-HU ,  TUOMINEN OLLI ,  STROUP ERIC W

Inventor： HO CHIH-HU ,  TUOMINEN OLLI ,  STROUP ERIC W

IPC: A61M37/00 ,  A41D19/00

CPC classification number: A61M1/3672 ,  A61L29/085 ,  A61L33/068 ,  A61M1/3673 ,  A61M25/0045 ,  C08L71/02

Abstract: A blood tubing set such as an arterial-venous blood tubing set used in hemodialysis is coated with a copolymer having a hydrophobic segment and a hydrophilic segment. For example, the coating can be PEO-PPO-PEO triblock copolymer. The hydrophobic segment attaches to the tubing set, and the hydrophilic segment prevents or reduces unwanted sorption on the blood tubing set.

Abstract translation: 在血液透析中使用的诸如动脉 - 静脉血管组之类的血管装置涂覆有具有疏水段和亲水段的共聚物。 例如，涂层可以是PEO-PPO-PEO三嵌段共聚物。 疏水段连接到管组上，并且亲水段防止或减少血管套上的不期望的吸附。