公开(公告)号：WO2007136592A2

公开(公告)日：2007-11-29

申请号：PCT/US2007/011484

申请日：2007-05-10

Applicant: AMPHORA DISCOVERY CORPORATION ,  DICKSON, John, K. ,  CHEN, Ke ,  HODGE, Carl, Nicholas

Inventor： DICKSON, John, K. ,  CHEN, Ke ,  HODGE, Carl, Nicholas

CPC classification number: C07D215/227 ,  C07D215/22

Abstract: Certain quinolone-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

Abstract translation: 公开了一些具有ATP利用酶抑制活性的喹诺酮类化合物，使用表现出ATP-利用酶抑制活性的化合物的方法，以及包含表现出ATP-利用酶抑制活性的化合物的组合物。

公开(公告)号：WO2007067711A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/046769

申请日：2006-12-05

Applicant: AMPHORA DISCOVERY CORPORATION ,  MENDOZA, Jose S. ,  HODGE, Carl Nicholas ,  DICKSON, John K., Jr.

Inventor： MENDOZA, Jose S. ,  HODGE, Carl Nicholas ,  DICKSON, John K., Jr.

IPC: A61K31/4745 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Provided are chemical entities chosen from compounds of Formula (I) and pharmaceutically or cosmetically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof. The chemical entities modulate TRPV1 and are useful in the treatment of at least one disease or disorder modulated by TRPV1 activity.

Abstract translation: 提供了选自式（I）化合物和其药学上或化妆上可接受的盐，溶剂合物，螯合物，非共价复合物，前药及其混合物的化学实体。 化学实体调节TRPV1并可用于治疗至少一种由TRPV1活性调节的疾病或病症。

公开(公告)号：WO2007067619A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/046549

申请日：2006-12-05

Applicant: AMPHORA DISCOVERY CORPORATION ,  MENDOZA, Jose, S. ,  HODGE, Carl, Nicholas ,  DICKSON, John, K., Jr.

Inventor： MENDOZA, Jose, S. ,  HODGE, Carl, Nicholas ,  DICKSON, John, K., Jr.

IPC: A61K31/165

CPC classification number: C07C233/75 ,  C07C235/56 ,  C07C311/17

Abstract: Provided are chemical entities chosen from compounds of Formula I and pharmaceutically or cosmetically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof. The chemical entities modulate TRPV1and are useful in the treatment of at least one disease or disorder modulated by TRPV1activity.

Abstract translation: 提供了选自式I化合物和其药学上或化妆上可接受的盐，溶剂合物，螯合物，非共价复合物，前体药物及其混合物的化学实体。 化学实体调节TRPV1并且可用于治疗至少一种由TRPV1活性调节的疾病或病症。

公开(公告)号：WO2008022002A3

公开(公告)日：2008-02-21

申请号：PCT/US2007/075648

申请日：2007-08-09

Applicant: GENENTECH, INC. ,  DICKSON, John, K., JR. ,  HODGE, Carl, Nicholas ,  CHEN, Ke

Inventor： DICKSON, John, K., JR. ,  HODGE, Carl, Nicholas ,  CHEN, Ke

IPC: C07D471/04 ,  C07D417/14 ,  A61K31/427 ,  A61P35/00

Abstract: 2-Amido-4-isoxazolyl thiazole compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

公开(公告)号：WO2007149395A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/014195

申请日：2007-06-15

Applicant: AMPHORA DISCOVERY CORPORATION ,  MENDOZA, Jose S. ,  DICKSON, JR., John K. ,  HODGE, Carl Nicholas

Inventor： MENDOZA, Jose S. ,  DICKSON, JR., John K. ,  HODGE, Carl Nicholas

IPC: C07D263/32 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  A61K31/421 ,  A61K31/422 ,  A61P35/00

CPC classification number: C07D263/32 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

Abstract: Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

Abstract translation: 公开了具有ATP利用酶抑制活性的某些基于恶唑的化合物，使用表现出ATP利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

公开(公告)号：WO2007067619A3

公开(公告)日：2007-12-13

申请号：PCT/US2006046549

申请日：2006-12-05

Applicant: AMPHORA DISCOVERY CORP ,  MENDOZA JOSE S ,  HODGE CARL NICHOLAS ,  DICKSON JOHN K JR

Inventor： MENDOZA JOSE S ,  HODGE CARL NICHOLAS ,  DICKSON JOHN K JR

IPC: A61K31/428

CPC classification number: C07C233/75 ,  C07C235/56 ,  C07C311/17

Abstract: Provided are chemical entities chosen from compounds of Formula I and pharmaceutically or cosmetically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof. The chemical entities modulate TRPV1and are useful in the treatment of at least one disease or disorder modulated by TRPV1activity.

Abstract translation: 提供的是选自式I化合物和药学或化妆品可接受的盐，溶剂合物，螯合物，非共价复合物，前药及其混合物的化学实体。 化学实体调节TRPV1，可用于治疗由TRPV1活性调节的至少一种疾病或病症。

公开(公告)号：WO2007067757A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/047003

申请日：2006-12-05

Applicant: AMPHORA DISCOVERY CORPORATION ,  MENDOZA, Jose S. ,  HODGE, Carl Nicholas ,  DICKSON, John K., Jr.

Inventor： MENDOZA, Jose S. ,  HODGE, Carl Nicholas ,  DICKSON, John K., Jr.

IPC: A61K31/428

CPC classification number: C07D277/64

Abstract: Provided are chemical entities chosen from compounds of Formula (I) and pharmaceutically or cosmetically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof. The chemical entities modulate TRPVl and are useful in the treatment of at least one disease or disorder modulated by TRPVl activity.

Abstract translation: 提供的是选自式（I）的化合物和药学或化学上可接受的盐，溶剂合物，螯合物，非共价复合物，前药及其混合物的化学实体。 化学实体调节TRPV1，并且可用于治疗由TRPV1活性调节的至少一种疾病或病症。

公开(公告)号：WO2006020767A2

公开(公告)日：2006-02-23

申请号：PCT/US2005028549

申请日：2005-08-11

Applicant: AMPHORA DISCOVERY CORP ,  DICKSON JOHN K JR ,  HODGE CARL NICHOLAS ,  MENDOZA JOSE SERAFIN ,  CHEN KE

Inventor： DICKSON JOHN K JR ,  HODGE CARL NICHOLAS ,  MENDOZA JOSE SERAFIN ,  CHEN KE

IPC: A61K31/4709 ,  A61K31/426 ,  A61K31/4439 ,  C07D417/02

CPC classification number: C07D417/04 ,  C07D277/46 ,  C07D417/12 ,  C07D417/14

Abstract: 2-Amido-4-substituted-aryl-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

Abstract translation: 公开了具有ATP利用酶抑制活性的2-酰氨基-4-取代 - 芳基 - 噻唑基化合物，使用显示出ATP-利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

公开(公告)号：WO2005120509A1

公开(公告)日：2005-12-22

申请号：PCT/US2005/019255

申请日：2005-06-03

Applicant: AMPHORA DISCOVERY CORPORATION ,  DICKSON, John, K., Jr. ,  WILLIAMS, Kevin, P. ,  HODGE, Carl, Nicholas

Inventor： DICKSON, John, K., Jr. ,  WILLIAMS, Kevin, P. ,  HODGE, Carl, Nicholas

IPC: A61K31/496

CPC classification number: A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

Abstract: Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

Abstract translation: 公开了具有ATP利用酶抑制活性的喹啉和异喹啉基化合物，使用显示出ATP利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

公开(公告)号：WO2005033102A3

公开(公告)日：2005-07-28

申请号：PCT/US2004032448

申请日：2004-10-01

Applicant: AMPHORA DISCOVERY CORP ,  HODGE CARL NICHOLAS ,  JANZEN WILLIAM P ,  WILLIAMS KEVIN PETER ,  CHEATHAM LYNN A

Inventor： HODGE CARL NICHOLAS ,  JANZEN WILLIAM P ,  WILLIAMS KEVIN PETER ,  CHEATHAM LYNN A

IPC: A61K31/33 ,  A61K31/381 ,  A61P3/10 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D249/02 ,  C07D333/36 ,  C07D333/38 ,  C07D333/40 ,  C07D333/66 ,  C07D333/68 ,  C07D333/78 ,  C07D333/80 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D495/18 ,  C07D513/04

CPC classification number: C07D249/02 ,  C07D333/36 ,  C07D333/38 ,  C07D333/66 ,  C07D333/68 ,  C07D333/78 ,  C07D333/80 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: Thiophene-based compounds of formula (I) exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed. These compounds are useful in the treatment of Alzheimer's disease, stroke, diabetes, obesity, inflammation and cancer.

Abstract translation: 公开了具有ATP利用酶抑制活性的式（I）的噻吩类化合物，使用表现出ATP-利用酶抑制活性的化合物的方法，以及包含表现出ATP-利用酶抑制活性的化合物的组合物。 这些化合物可用于治疗阿尔茨海默病，中风，糖尿病，肥胖，炎症和癌症。