公开(公告)号：WO0233059A9

公开(公告)日：2003-09-12

申请号：PCT/US0132493

申请日：2001-10-17

Applicant: IMMUNEX CORP ,  HOLLAND PAMELA M ,  VIRCA G DUKE ,  BIRD TIMOTHY A ,  GARKA KIRSTEN

Inventor： HOLLAND PAMELA M ,  VIRCA G DUKE ,  BIRD TIMOTHY A ,  GARKA KIRSTEN

IPC: C12N9/88 ,  C12N15/60 ,  C07K16/40 ,  C12N5/10 ,  C12N5/12 ,  C12N15/62 ,  C12Q1/52

CPC classification number: C12N9/88 ,  C07K2319/00

Abstract: The present invention discloses a novel polypeptide that contains an amino acid decarboxylase domain, and is a substrate for caspase-3. Nucleic acids that encode the novel polypeptide and antibodies to the polypeptide are also part of the present invention. Methods of using the polypeptide, the nucleic acids and antibodies are also provided.

Abstract translation: 本发明公开了含有氨基酸脱羧酶结构域的新型多肽，并且是胱天蛋白酶-3的底物。 编码新多肽的核酸和该多肽的抗体也是本发明的一部分。 还提供了使用多肽，核酸和抗体的方法。

公开(公告)号：WO1992002638A1

公开(公告)日：1992-02-20

申请号：PCT/US1991005571

申请日：1991-08-06

Applicant: CETUS CORPORATION ,  GELFAND, David, H. ,  HOLLAND, Pamela, M. ,  SAIKI, Randall, K. ,  WATSON, Robert, M.

Inventor： CETUS CORPORATION

IPC: C12Q01/68

CPC classification number: C12Q1/686 ,  C07H21/00 ,  C12Q1/6818 ,  C12Q1/6823 ,  C12Q1/6827 ,  C12Q1/703 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S436/815 ,  C12Q2521/101 ,  C12Q2565/1015 ,  C12Q2531/113 ,  C12Q2521/319 ,  C12Q2535/131 ,  C12Q2521/325 ,  C12Q2537/157 ,  C12Q2561/101 ,  C12Q2525/186 ,  C12Q2525/131

Abstract: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.

公开(公告)号：WO2010033315A1

公开(公告)日：2010-03-25

申请号：PCT/US2009/052789

申请日：2009-08-05

Applicant: AMGEN INC. ,  TETRALOGIC PHARMACEUTICALS ,  HOLLAND, Pamela, M. ,  PIASECKI, Julia, C. ,  BENETATOS, Christopher, A. ,  CHUNDURU, Srinivas, K. ,  MCKINLAY, Mark, A.

Inventor： HOLLAND, Pamela, M. ,  PIASECKI, Julia, C. ,  BENETATOS, Christopher, A. ,  CHUNDURU, Srinivas, K. ,  MCKINLAY, Mark, A.

IPC: G01N33/48

CPC classification number: A61K45/06 ,  A61K38/177 ,  A61K38/1793 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/2878 ,  C07K2317/76 ,  A61K2300/00

Abstract: The invention provides methods for inducing apoptosis. comprising treatment of a patient with a TNFα inhibitor as well as with an IAP inhibitor and a TRAIL receptor agonist. The methods ameliorate the risk of unwanted effects, thereby resulting in an improved therapeutic index for IAP inhibitors in combination with a TRAIL receptor agonist.

Abstract translation: 本发明提供诱导凋亡的方法。 包括用TNFα抑制剂以及IAP抑制剂和TRAIL受体激动剂治疗患者。 该方法改善不需要的作用的风险，从而导致IAP抑制剂与TRAIL受体激动剂组合改善的治疗指数。

公开(公告)号：WO0233059A3

公开(公告)日：2003-05-22

申请号：PCT/US0132493

申请日：2001-10-17

Applicant: IMMUNEX CORP ,  HOLLAND PAMELA M ,  VIRCA G DUKE ,  BIRD TIMOTHY A ,  GARKA KIRSTEN

Inventor： HOLLAND PAMELA M ,  VIRCA G DUKE ,  BIRD TIMOTHY A ,  GARKA KIRSTEN

IPC: C12N9/88 ,  C12N15/60 ,  C07K16/40 ,  C12N5/10 ,  C12N5/12 ,  C12N15/62 ,  C12Q1/52

CPC classification number: C12N9/88 ,  C07K2319/00

Abstract: The present invention discloses a novel polypeptide that contains an amino acid decarboxylase domain, and is a substrate for caspase-3. Nucleic acids that encode the novel polypeptide and antibodies to the polypeptide are also part of the present invention. Methods of using the polypeptide, the nucleic acids and antibodies are also provided.

Abstract translation: 本发明公开了一种含有氨基酸脱羧酶结构域的新型多肽，是胱天蛋白酶-3的底物。 编码新多肽的核酸和多肽的抗体也是本发明的一部分。 还提供了使用多肽，核酸和抗体的方法。

公开(公告)号：WO2002098894A1

公开(公告)日：2002-12-12

申请号：PCT/US2002/018039

申请日：2002-06-04

Applicant: IMMUNEX CORPORATION ,  BIRD, Timothy, A. ,  HOLLAND, Pamela, M. ,  PESCHON, Jacques, J. ,  VIRCA, George, D.

Inventor： BIRD, Timothy, A. ,  HOLLAND, Pamela, M. ,  PESCHON, Jacques, J. ,  VIRCA, George, D.

IPC: C07H21/02

CPC classification number: C12N9/1205

Abstract: This invention relates to DAKAR, a new member of the serine/threonine kinase family, methods of making such polypeptides, and to methods of using them to treat conditions associated with apoptosis and epithelial proliferation and differentiation, as well as methods to identify compounds that alter DAKAR-associated cellular activities.

Abstract translation: 本发明涉及DAKAR，丝氨酸/苏氨酸激酶家族的新成员，制备这些多肽的方法，以及使用它们来治疗与凋亡和上皮细胞增殖和分化相关的病症的方法，以及鉴定化合物的方法 DAKAR相关细胞活性。