公开(公告)号：WO2008000745A3

公开(公告)日：2008-04-17

申请号：PCT/EP2007056378

申请日：2007-06-26

Applicant: BIOVITRUM AB PUBL ,  HIGGINBOTTOM MICHAEL ,  SAVORY EDWARD DANIEL ,  BROWN GILES ALBERT ,  HORGAN VIET-ANH ANNE NEE NGUYE ,  CHAPMAN EMMA JANE

Inventor： HIGGINBOTTOM MICHAEL ,  SAVORY EDWARD DANIEL ,  BROWN GILES ALBERT ,  HORGAN VIET-ANH ANNE NEE NGUYE ,  CHAPMAN EMMA JANE

IPC: C07H19/16 ,  A61K31/7076 ,  A61P25/04

CPC classification number: C07H19/16

Abstract: Compounds of formula (I) are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation. In said Fomula, when X=Y=Z=OH, R 1 is OCH 2 CF 2 CF 3 , phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; or when X=Y=OH and Z=OMe, R 1 is OCH 3 , OCH 2 CHF 2 , OCH 2 cyclopentyl, O-(2,5- difluorophenyl) or (S)-sec-butylamino; or when X=H and Y=Z=OH, R 1 is n-hexylamino or cyclopentylamino; or when (IV) X=Z=OH and Y=H, R 1 is cyclopentylamino;or a pharmaceutically acceptable salt thereof.

Abstract translation: 公开了式（I）的化合物。 描述了它们作为药物的用途，特别是用于治疗疼痛或炎症。 在所述的Fomula中，当X = Y = Z = OH时，R 1是CH 2 CH 2 CH 2 CF 3 ，苯氧基（被3-（4-三氟甲基苯基），3,4-二氯，（3-三氟甲基，4-氟），（3-三氟甲基，4-氯），（3-氯，4-氰基） （三氟甲基）），1-哌嗪基（4-（3,4-二氯苯基）），苯基（被3,4-二氯，3,5-二氟，3,5-双（三氟甲基）或 3,4,5-三氟）或2-苯并呋喃基; 或当X = Y = OH且Z = OMe时，R 1是OCH 3，OCH 2 CHF 2， ，OCH 2 - 环戊基，O-（2,5-二氟苯基）或（S） - 仲丁基氨基; 或当X = H且Y = Z = OH时，R 1是正己基氨基或环戊基氨基; 或当（IV）X = Z = OH且Y = H时，R 1是环戊基氨基;或其药学上可接受的盐。

公开(公告)号：WO2009071668A3

公开(公告)日：2009-08-20

申请号：PCT/EP2008066899

申请日：2008-12-05

Applicant: BIOVITRUM AB PUBL ,  BOYD JOSEPH W ,  BROWN GILES A ,  HIGGINBOTTOM MICHAEL ,  SIMPSON IAIN ,  HORGAN VIET-ANH ANNE NEE NGUYE ,  OUZMAN JACQUELINE

Inventor： BOYD JOSEPH W ,  BROWN GILES A ,  HIGGINBOTTOM MICHAEL ,  SIMPSON IAIN ,  HORGAN VIET-ANH ANNE ,  OUZMAN JACQUELINE

IPC: C07D295/205 ,  A61K31/445 ,  A61K31/495 ,  A61P3/00

CPC classification number: C07D295/205

Abstract: The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds, to processes for their preparation, and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

Abstract translation: 本发明涉及新的式（I）化合物，包含这些化合物的药物组合物，其制备方法以及这些化合物作为瘦素受体调节剂模拟物在制备抗体与体重增加相关的病症中的用途， 2型糖尿病和血脂异常。

公开(公告)号：WO2009071678A3

公开(公告)日：2009-07-23

申请号：PCT/EP2008066917

申请日：2008-12-05

Applicant: BIOVITRUM AB PUBL ,  HIGGINBOTTOM MICHAEL ,  HORGAN VIET-ANH ANNE NEE NGUYE ,  SIMPSON IAIN

Inventor： HIGGINBOTTOM MICHAEL ,  HORGAN VIET-ANH ANNE NEE NGUYEN ,  SIMPSON IAIN

IPC: C07D211/34 ,  A61K31/445 ,  A61P3/00 ,  C07D295/205

CPC classification number: C07D211/34 ,  C07D295/205

Abstract: The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising the compounds, to processes for their preparation, and to the use of the compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

Abstract translation: 本发明涉及新的式（I）化合物，包含该化合物的药物组合物，其制备方法，以及该化合物作为瘦蛋白受体调节剂模拟物在制备抗体与增重相关的病症中的用途， 2型糖尿病和血脂异常。