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公开(公告)号：WO2014159242A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/022658
申请日：2014-03-10
Applicant: NOVARTIS AG , FRYER, Christy , HU, Tiancen , JENKINS, David
Inventor： FRYER, Christy , HU, Tiancen , JENKINS, David
IPC: C07K14/705 , C07K16/28
CPC classification number: C07K16/28 , C07K14/705 , G01N33/57488
Abstract: The present invention relates to the field of pharmacogenomics. In particular, the present invention relates to Notch 3 mutants and uses thereof.
Abstract translation: 本发明涉及药物基因组学领域。 特别地，本发明涉及Notch 3突变体及其用途。
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公开(公告)号：WO2014160160A3
公开(公告)日：2015-01-08
申请号：PCT/US2014025944
申请日：2014-03-13
Applicant: NOVARTIS AG , BATT JULIE LYNN , ETTENBERG SETH , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , MOSHER REBECCA , MEYER MATTHEW JOHN , PETROPOULOS KONSTANTIN
Inventor： ETTENBERG SETH , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , MOSHER REBECCA , MEYER MATTHEW JOHN , PETROPOULOS KONSTANTIN , BATT DAVID BRYANT
CPC classification number: C07K16/30 , A61K31/506 , A61K45/06 , A61K47/549 , A61K47/6803 , A61K47/6849 , A61K47/6879 , A61K2039/505 , C07K16/2863 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
Abstract translation: 本发明涉及抗FGFR2和FGFR4抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。
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公开(公告)号：WO2016024195A1
公开(公告)日：2016-02-18
申请号：PCT/IB2015/056032
申请日：2015-08-07
Applicant: NOVARTIS AG , BIALUCHA, Carl Uli , COLLINS, Scott , DÜRR, Clemens , HU, Tiancen , JANATPOUR, Mary Jo , MEYER, Matthew John
Inventor： BIALUCHA, Carl Uli , COLLINS, Scott , HU, Tiancen , JANATPOUR, Mary Jo , MEYER, Matthew John
IPC: C07K16/28 , A61K39/395 , A61P35/00 , A61K31/00
CPC classification number: C07K16/28 , A61K31/4738 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6889 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/92 , G01N33/57492 , G01N2333/705 , A61K2300/00 , A61K39/395
Abstract: The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
Abstract translation: 本发明涉及抗CDH6抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。
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公开(公告)号：WO2014163714A2
公开(公告)日：2014-10-09
申请号：PCT/US2014000052
申请日：2014-03-13
Applicant: BATT DAVID BRYANT , ETTENBERG SETH ALEXANDER , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , PETROPOULOS KONSTANTIN , MEYER MATTHEW JOHN , NOVARTIS AG
Inventor： BATT DAVID BRYANT , ETTENBERG SETH ALEXANDER , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , PETROPOULOS KONSTANTIN , MEYER MATTHEW JOHN
CPC classification number: C07K16/2863 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/662 , A61K45/06 , A61K47/48384 , A61K47/48561 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/565 , C07K2317/732 , C07K2317/92 , A61K2300/00
Abstract: The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
Abstract translation: 本发明涉及抗FGFR2抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。
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Patent Agency Ranking
公开(公告)号：WO2014159239A3
公开(公告)日：2015-02-19
申请号：PCT/US2014022642
申请日：2014-03-10
Applicant: NOVARTIS AG , DEPLAZES-LAUBER JOELLE , FRYER CHRISTY , HU TIANCEN , JENKINS DAVID , PETROPOULOS KONSTANTIN , THIEL PHILIPPE
Inventor： DEPLAZES-LAUBER JOELLE , FRYER CHRISTY , HU TIANCEN , JENKINS DAVID , PETROPOULOS KONSTANTIN , THIEL PHILIPPE
IPC: C07K16/28 , A61K39/395
CPC classification number: C07K16/28 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57484 , G01N2800/50 , G01N2800/7028
Abstract: The present disclosure relates to antibodies or fragments thereof that target at least one conformational epitope of a Notch 3 or mutant Notch 3 receptor; and compositions and methods of use thereof.
Abstract translation: 本公开涉及靶向Notch 3或突变型Notch 3受体的至少一个构象表位的抗体或其片段; 及其组合物和使用方法。
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公开(公告)号：WO2014163714A3
公开(公告)日：2014-10-09
申请号：PCT/US2014/000052
申请日：2014-03-13
Applicant: BATT, David, Bryant , ETTENBERG, Seth, Alexander , HAUBST, Nicole , HU, Tiancen , JENKINS, David , TOKSOZ, Engin , PETROPOULOS, Konstantin , MEYER, Matthew, John , NOVARTIS AG
Inventor： BATT, David, Bryant , ETTENBERG, Seth, Alexander , HAUBST, Nicole , HU, Tiancen , JENKINS, David , TOKSOZ, Engin , PETROPOULOS, Konstantin , MEYER, Matthew, John
Abstract: The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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公开(公告)号：WO2017019897A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044549
申请日：2016-07-28
Applicant: NOVARTIS AG , DANA-FARBER CANCER INSTITUTE, INC. , CHILDREN'S MEDICAL CENTER CORPORATION , DRANOFF, Glenn , SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
Inventor： DRANOFF, Glenn , SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
CPC classification number: A61K39/00 , C07K16/2803 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/94 , A61K2300/00
Abstract: Combination therapies comprising antibody molecules that specifically bind to TIM-3 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.
Abstract translation: 公开了包含特异性结合TIM-3的抗体分子的组合疗法。 联合治疗可用于治疗或预防癌性或感染性疾病和病症。
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公开(公告)号：WO2014160160A2
公开(公告)日：2014-10-02
申请号：PCT/US2014/025944
申请日：2014-03-13
Applicant: NOVARTIS AG , BATT, Julie Lynn , ETTENBERG, Seth , HAUBST, Nicole , HU, Tiancen , JENKINS, David , TOKSOZ, Engin , MOSHER, Rebecca , MEYER, Matthew John , PETROPOULOS, Konstantin
Inventor： ETTENBERG, Seth , HAUBST, Nicole , HU, Tiancen , JENKINS, David , TOKSOZ, Engin , MOSHER, Rebecca , MEYER, Matthew John , PETROPOULOS, Konstantin
IPC: A61K47/48
CPC classification number: C07K16/30 , A61K31/506 , A61K45/06 , A61K47/549 , A61K47/6803 , A61K47/6849 , A61K47/6879 , A61K2039/505 , C07K16/2863 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
Abstract translation: 本发明涉及抗FGFR2和FGFR4抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。
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公开(公告)号：WO2014159239A2
公开(公告)日：2014-10-02
申请号：PCT/US2014/022642
申请日：2014-03-10
Applicant: NOVARTIS AG , DEPLAZES-LAUBER, Joelle , FRYER, Christy , HU, Tiancen , JENKINS, David , PETROPOULOS, Konstantin , THIEL, Philippe
Inventor： DEPLAZES-LAUBER, Joelle , FRYER, Christy , HU, Tiancen , JENKINS, David , PETROPOULOS, Konstantin , THIEL, Philippe
CPC classification number: C07K16/28 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57484 , G01N2800/50 , G01N2800/7028
Abstract: The present disclosure relates to antibodies or fragments thereof that target at least one conformational epitope of a Notch 3 or mutant Notch 3 receptor; and compositions and methods of use thereof.
Abstract translation: 本公开涉及靶向Notch 3或突变型Notch 3受体的至少一个构象表位的抗体或其片段; 及其组合物和使用方法。
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