公开(公告)号：WO2005123127A2

公开(公告)日：2005-12-29

申请号：PCT/US2005/020418

申请日：2005-06-09

Applicant: CHIRON CORPORATION ,  JANATPOUR, Mary Jo ,  GARCIA, Pablo ,  REINHARD, Christoph

Inventor： JANATPOUR, Mary Jo ,  GARCIA, Pablo ,  REINHARD, Christoph

IPC: A61K39/395

CPC classification number: C12N9/6424

Abstract: PRSS 15, or human Lon protease, is upregulated in many cancers and contributes to the malignant phenotype. Detection of PRSS15 is useful to diagnose such cancers and modulation of PRSS 15 biological activity is useful to treat such cancers.

Abstract translation: PRSS 15或人类Lon蛋白酶在许多癌症中上调，并有助于恶性表型。 PRSS15的检测对于诊断这种癌症是有用的，并且调节PRSS 15生物活性可用于治疗这种癌症。

公开(公告)号：WO2006132907A2

公开(公告)日：2006-12-14

申请号：PCT/US2006021246

申请日：2006-06-02

Applicant: NOVARTIS VACCINES & DIAGNOSTIC ,  ZIMMERMAN DEBORAH LEE ,  JANATPOUR MARY JO

Inventor： ZIMMERMAN DEBORAH LEE ,  JANATPOUR MARY JO

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2866 ,  C07K2319/30

Abstract: The invention provides, inter alia, methods for treating cancer, compositions for treating cancer, and methods and compositions for diagnosing and/or detecting cancer. In particular, the present invention provides compositions and methods for treating, diagnosing and detecting cancers associated with EphB3 overexpression

Abstract translation: 本发明尤其提供了治疗癌症的方法，用于治疗癌症的组合物，以及用于诊断和/或检测癌症的方法和组合物。 特别地，本发明提供了用于治疗，诊断和检测与EphB3过度表达相关的癌症的组合物和方法

公开(公告)号：WO2006132907A3

公开(公告)日：2006-12-14

申请号：PCT/US2006/021246

申请日：2006-06-02

Applicant: NOVARTIS VACCINES AND DIAGNOSTICS INC. ,  ZIMMERMAN, Deborah, Lee ,  JANATPOUR, Mary, Jo

Inventor： ZIMMERMAN, Deborah, Lee ,  JANATPOUR, Mary, Jo

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00

Abstract: The invention provides, inter alia, methods for treating cancer, compositions for treating cancer, and methods and compositions for diagnosing and/or detecting cancer. In particular, the present invention provides compositions and methods for treating, diagnosing and detecting cancers associated with EphB3 overexpression

公开(公告)号：WO2016024195A1

公开(公告)日：2016-02-18

申请号：PCT/IB2015/056032

申请日：2015-08-07

Applicant: NOVARTIS AG ,  BIALUCHA, Carl Uli ,  COLLINS, Scott ,  DÜRR, Clemens ,  HU, Tiancen ,  JANATPOUR, Mary Jo ,  MEYER, Matthew John

Inventor： BIALUCHA, Carl Uli ,  COLLINS, Scott ,  HU, Tiancen ,  JANATPOUR, Mary Jo ,  MEYER, Matthew John

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K31/00

CPC classification number: C07K16/28 ,  A61K31/4738 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6889 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/705 ,  A61K2300/00 ,  A61K39/395

Abstract: The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract translation: 本发明涉及抗CDH6抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。