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    NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM
    3.
    发明申请
    NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM 审中-公开
    核酸和蛋白质及其制备和使用方法

    公开(公告)号：WO2008143679A8

    公开(公告)日：2009-01-29

    申请号：PCT/US2007070284

    申请日：2007-06-01

    申请人： VERENIUM CORP ,  UNIV CALIFORNIA ,  CALIFORNIA INST OF TECHN ,  CHANG CATHY ,  MATHUR ERIC J ,  CAYOUETTE MICHELLE ,  ROBERTSON DAN E ,  HUGENHOLTZ PHILIP ,  WARNECKE FALK ,  LEADBETTER JARED ,  IVANOVA NATALIA ,  LUGINBUHL PETER ,  HUTCHISON DON

    发明人： CHANG CATHY ,  MATHUR ERIC J ,  CAYOUETTE MICHELLE ,  ROBERTSON DAN E ,  HUGENHOLTZ PHILIP ,  WARNECKE FALK ,  LEADBETTER JARED ,  IVANOVA NATALIA ,  LUGINBUHL PETER ,  HUTCHISON DON

    IPC分类号： C12N9/24

    CPC分类号： C12Y302/01015 ,  C12N9/2437 ,  C12Y302/01004 ,  C12Y302/01006 ,  C12Y302/01039 ,  C12Y302/01067 ,  C12Y302/01082

    摘要： The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs. Polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to a biofuel (e.g., a bioethanol, biomethanol, biopropanol or biobutanol, a biodiesel, etc.), biodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.

    摘要翻译： 本发明提供多肽，包括酶，结构蛋白和结合蛋白，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 本发明的多肽，包括酶和抗体以及核酸可用于工业，实验，食品和饲料加工，营养和药物应用中，例如用于食品和饲料添加剂，着色剂，中性药物，化妆品和药物需求。 本发明的多肽可用于食品加工，酿造，浴添加剂，酒精生产，肽合成，对映选择性，皮革行业中的皮革制备，废物管理和动物降解，摄影工业中的银回收，医疗，丝绸脱胶， 生物膜降解，生物燃料转化为生物燃料（例如生物乙醇，生物甲醇，生物丙醇或生物丁醇，生物柴油等），生物防治剂，抗微生物剂和消毒剂，个人护理和化妆品，生物技术试剂，玉米湿法研磨和药物如 消化助剂和抗炎（抗炎）药剂。

    COMPOSITIONS AND METHODS FOR DOWNREGULATING PROKARYOTIC GENES
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR DOWNREGULATING PROKARYOTIC GENES 审中-公开
    用于下调原核生物基因的组合物和方法

    公开(公告)号：WO2010075424A2

    公开(公告)日：2010-07-01

    申请号：PCT/US2009069258

    申请日：2009-12-22

    申请人： UNIV CALIFORNIA ,  KUNIN VICTOR ,  YILMAZ SUSAN ,  SOREK ROTEM ,  HUGENHOLTZ PHILIP

    发明人： KUNIN VICTOR ,  YILMAZ SUSAN ,  SOREK ROTEM ,  HUGENHOLTZ PHILIP

    IPC分类号： A61K48/00

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2330/51

    摘要： An isolated polynucleotide is disclosed. The polynucleotide comprises a clustered, regularly interspaced short palindromic repeat (CRISPR) array nucleic acid sequence wherein at least one spacer of the CRISPR is sufficiently complementary to a portion of at least one prokaryotic gene so as to down-regulate expression of the prokaryotic gene. Uses of the polynucleotides and pharmaceutical compositions comprising the polynucleotides are also disclosed.

    摘要翻译： 公开了一种分离的多核苷酸。 多核苷酸包含聚集的，规则间隔的短回文重复（CRISPR）阵列核酸序列，其中CRISPR的至少一个间隔基与至少一个原核基因的一部分充分互补，以便下调原核基因的表达。 还公开了包含多核苷酸的多核苷酸和药物组合物的用途。