公开(公告)号：WO2012115493A3

公开(公告)日：2012-12-20

申请号：PCT/KR2012001471

申请日：2012-02-27

Applicant: KOREA OCEAN RES & DEV INST ,  KANG SUNG GYUN ,  LEE HYUN SOOK ,  LEE JUNG-HYUN ,  KIM SANG-JIN ,  KWON KAE KYONG ,  YIM HYUNG-SOON ,  KIM YUN JAE ,  HWANG YOUNG OK ,  JIN WOOK ,  CHO YONG KYUN

Inventor： KANG SUNG GYUN ,  LEE HYUN SOOK ,  LEE JUNG-HYUN ,  KIM SANG-JIN ,  KWON KAE KYONG ,  YIM HYUNG-SOON ,  KIM YUN JAE ,  HWANG YOUNG OK ,  JIN WOOK ,  CHO YONG KYUN

IPC: G01N33/574 ,  C12N15/11 ,  C12N15/115 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N33/57438 ,  G01N33/5748

Abstract: The present invention relates to a kit for cancer diagnosis or prognosis analysis. An MEST according to the present invention is a marker for cancer having significantly improved accuracy and reliability. Particularly, the marker of the present invention has superior accuracy and reliability as a marker for breast cancer and liver cancer. The MEST of the present invention exhibits extremely superior accuracy and reliability as a marker for metastatic cancer. Moreover, according to the present invention, early cancer diagnosis and prognostic determination may be enabled in a very specific manner from a biological sample (for example, blood or serum) using the MEST, the expression of which specifically increases only in the cells and tissue of a cancer patient.

Abstract translation: 本发明涉及用于癌症诊断或预后分析的试剂盒。 根据本发明的MEST是具有显着提高的准确度和可靠性的癌症标志物。 特别是，本发明的标志物作为乳腺癌和肝癌的标志物具有优异的准确性和可靠性。 本发明的MEST作为转移癌的标记物显示出非常优异的准确度和可靠性。 此外，根据本发明，可以使用MEST以非常特定的方式从生物样品（例如血液或血清）中进行早期癌症诊断和预后判定，所述MEST仅在细胞和组织中表达特异性地增加 的癌症患者。

公开(公告)号：WO2012115493A2

公开(公告)日：2012-08-30

申请号：PCT/KR2012001471

申请日：2012-02-27

Applicant: KOREA OCEAN RES & DEV INST ,  KANG SUNG GYUN ,  LEE HYUN SOOK ,  LEE JUNG-HYUN ,  KIM SANG-JIN ,  KWON KAE KYONG ,  YIM HYUNG-SOON ,  KIM YUN JAE ,  HWANG YOUNG OK ,  JIN WOOK ,  CHO YONG KYUN

Inventor： KANG SUNG GYUN ,  LEE HYUN SOOK ,  LEE JUNG-HYUN ,  KIM SANG-JIN ,  KWON KAE KYONG ,  YIM HYUNG-SOON ,  KIM YUN JAE ,  HWANG YOUNG OK ,  JIN WOOK ,  CHO YONG KYUN

IPC: G01N33/574 ,  C12N15/11 ,  C12N15/115 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N33/57438 ,  G01N33/5748

Abstract: The present invention relates to a kit for cancer diagnosis or prognosis analysis. An MEST according to the present invention is a marker for cancer having significantly improved accuracy and reliability. Particularly, the marker of the present invention has superior accuracy and reliability as a marker for breast cancer and liver cancer. The MEST of the present invention exhibits extremely superior accuracy and reliability as a marker for metastatic cancer. Moreover, according to the present invention, early cancer diagnosis and prognostic determination may be enabled in a very specific manner from a biological sample (for example, blood or serum) using the MEST, the expression of which specifically increases only in the cells and tissue of a cancer patient.

Abstract translation: 本发明涉及用于癌症诊断或预后分析的试剂盒。 根据本发明的MEST是具有显着提高的准确性和可靠性的癌症标志物。 特别地，本发明的标记作为乳腺癌和肝癌的标志物具有优异的准确性和可靠性。 作为转移性癌症的标志物，本发明的MEST显示出极高的精度和可靠性。 此外，根据本发明，可以以非常特定的方式从使用MEST的生物学样品（例如血液或血清）中进行早期癌症诊断和预后测定，MEST的表达仅在细胞和组织中特异性增加 的癌症患者。

公开(公告)号：WO2007043777A1

公开(公告)日：2007-04-19

申请号：PCT/KR2006/004003

申请日：2006-10-04

Applicant: KOREA OCEAN RESEARCH AND DEVELOPMENT INSTITUTE ,  KIM, Sang-Jin ,  KANG, Sung-Gyun ,  HWANG, Young-Ok ,  WOO, Jeong-Hee ,  CHO, Jang-Cheon ,  KANG, Ji-Hyun ,  KWON, Kae-Kyoung

Inventor： KIM, Sang-Jin ,  KANG, Sung-Gyun ,  HWANG, Young-Ok ,  WOO, Jeong-Hee ,  CHO, Jang-Cheon ,  KANG, Ji-Hyun ,  KWON, Kae-Kyoung

IPC: C12N9/14 ,  C12P41/00

CPC classification number: C12P17/02 ,  C12N9/14 ,  C12P41/004

Abstract: The present invention relates to enantioselective epoxide hydrolase proteins isolated from marine microorganisms, which has high enantioselectivity to various epoxide substrates, and a method of preparing the epoxides with high enantio-purity by using the epoxide hydrolases. The enantioselective hydrolase protein of the present invention can be applied for the preparation of enantiopure epoxides with high bioactivity at a high yield.

Abstract translation: 本发明涉及从海洋微生物分离的对映选择性环氧化物水解酶蛋白质，其对各种环氧化物底物具有高对映体选择性，以及通过使用环氧化物水解酶制备具有高对映纯度的环氧化物的方法。 本发明的对映选择性水解酶蛋白可以以高产率应用于具有高生物活性的对映体纯环氧化物。