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公开(公告)号：WO2012115493A3
公开(公告)日：2012-12-20
申请号：PCT/KR2012001471
申请日：2012-02-27
Applicant: KOREA OCEAN RES & DEV INST , KANG SUNG GYUN , LEE HYUN SOOK , LEE JUNG-HYUN , KIM SANG-JIN , KWON KAE KYONG , YIM HYUNG-SOON , KIM YUN JAE , HWANG YOUNG OK , JIN WOOK , CHO YONG KYUN
Inventor： KANG SUNG GYUN , LEE HYUN SOOK , LEE JUNG-HYUN , KIM SANG-JIN , KWON KAE KYONG , YIM HYUNG-SOON , KIM YUN JAE , HWANG YOUNG OK , JIN WOOK , CHO YONG KYUN
IPC: G01N33/574 , C12N15/11 , C12N15/115 , C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57415 , G01N33/57438 , G01N33/5748
Abstract: The present invention relates to a kit for cancer diagnosis or prognosis analysis. An MEST according to the present invention is a marker for cancer having significantly improved accuracy and reliability. Particularly, the marker of the present invention has superior accuracy and reliability as a marker for breast cancer and liver cancer. The MEST of the present invention exhibits extremely superior accuracy and reliability as a marker for metastatic cancer. Moreover, according to the present invention, early cancer diagnosis and prognostic determination may be enabled in a very specific manner from a biological sample (for example, blood or serum) using the MEST, the expression of which specifically increases only in the cells and tissue of a cancer patient.
Abstract translation: 本发明涉及用于癌症诊断或预后分析的试剂盒。 根据本发明的MEST是具有显着提高的准确度和可靠性的癌症标志物。 特别是，本发明的标志物作为乳腺癌和肝癌的标志物具有优异的准确性和可靠性。 本发明的MEST作为转移癌的标记物显示出非常优异的准确度和可靠性。 此外，根据本发明，可以使用MEST以非常特定的方式从生物样品（例如血液或血清）中进行早期癌症诊断和预后判定，所述MEST仅在细胞和组织中表达特异性地增加 的癌症患者。
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公开(公告)号：WO2008066350A1
公开(公告)日：2008-06-05
申请号：PCT/KR2007/006150
申请日：2007-11-30
Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTE , LEE, Jung Hyun , KANG, Sung Gyun , KIM, Sang Jin , KWON, Kae Kyoung , LEE, Hyun Sook , KIM, Yun Jae , RYU, Yong Gu , BAE, Seung Seob , LIM, Jae Kyu , JEON, Jung Ho , CHO, Yo Na , JEONG, Insoon , KWON, Suk Tae , CHA, Sun Shin
Inventor： LEE, Jung Hyun , KANG, Sung Gyun , KIM, Sang Jin , KWON, Kae Kyoung , LEE, Hyun Sook , KIM, Yun Jae , RYU, Yong Gu , BAE, Seung Seob , LIM, Jae Kyu , JEON, Jung Ho , CHO, Yo Na , JEONG, Insoon , KWON, Suk Tae , CHA, Sun Shin
IPC: C07K14/195
CPC classification number: C12N9/16
Abstract: The present invention relates to a novel dITPase, protein for enhancing DNA polymerase activity, and genes encoding it. More specifically, the present invention relates to a dITPase isolated from Thermococcus sp NAl. strain. Also, the present invention provides gene fragments encoding said protein, recombinant vectors containing thereof, host cells transformed with thereof and methods for producing dITPase using said host cells.
Abstract translation: 本发明涉及一种新的dITPase，用于增强DNA聚合酶活性的蛋白质和编码它的基因。 更具体地说，本发明涉及从Thermococcus sp NA1分离的dITPase。 应变。 此外，本发明提供编码所述蛋白质的基因片段，含有其的重组载体，用其转化的宿主细胞和使用所述宿主细胞产生dITPase的方法。
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Patent Agency Ranking
公开(公告)号：WO2012115493A2
公开(公告)日：2012-08-30
申请号：PCT/KR2012001471
申请日：2012-02-27
Applicant: KOREA OCEAN RES & DEV INST , KANG SUNG GYUN , LEE HYUN SOOK , LEE JUNG-HYUN , KIM SANG-JIN , KWON KAE KYONG , YIM HYUNG-SOON , KIM YUN JAE , HWANG YOUNG OK , JIN WOOK , CHO YONG KYUN
Inventor： KANG SUNG GYUN , LEE HYUN SOOK , LEE JUNG-HYUN , KIM SANG-JIN , KWON KAE KYONG , YIM HYUNG-SOON , KIM YUN JAE , HWANG YOUNG OK , JIN WOOK , CHO YONG KYUN
IPC: G01N33/574 , C12N15/11 , C12N15/115 , C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57415 , G01N33/57438 , G01N33/5748
Abstract: The present invention relates to a kit for cancer diagnosis or prognosis analysis. An MEST according to the present invention is a marker for cancer having significantly improved accuracy and reliability. Particularly, the marker of the present invention has superior accuracy and reliability as a marker for breast cancer and liver cancer. The MEST of the present invention exhibits extremely superior accuracy and reliability as a marker for metastatic cancer. Moreover, according to the present invention, early cancer diagnosis and prognostic determination may be enabled in a very specific manner from a biological sample (for example, blood or serum) using the MEST, the expression of which specifically increases only in the cells and tissue of a cancer patient.
Abstract translation: 本发明涉及用于癌症诊断或预后分析的试剂盒。 根据本发明的MEST是具有显着提高的准确性和可靠性的癌症标志物。 特别地，本发明的标记作为乳腺癌和肝癌的标志物具有优异的准确性和可靠性。 作为转移性癌症的标志物，本发明的MEST显示出极高的精度和可靠性。 此外，根据本发明，可以以非常特定的方式从使用MEST的生物学样品（例如血液或血清）中进行早期癌症诊断和预后测定，MEST的表达仅在细胞和组织中特异性增加 的癌症患者。
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公开(公告)号：WO2008066245A1
公开(公告)日：2008-06-05
申请号：PCT/KR2007/004827
申请日：2007-10-02
Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTE , LEE, Jung Hyun , KANG, Sung Gyun , KIM, Sang Jin , KWON, Kae Kyoung , LEE, Hyun Sook , KIM, Yun Jae , RYU, Yong Gu , BAE, Seung Seob , LIM, Jae Kyu , JEON, Jung Ho , CHO, Yo Na , JEONG, Insoon , KWON, Suk Tae , CHA, Sun Shin
Inventor： LEE, Jung Hyun , KANG, Sung Gyun , KIM, Sang Jin , KWON, Kae Kyoung , LEE, Hyun Sook , KIM, Yun Jae , RYU, Yong Gu , BAE, Seung Seob , LIM, Jae Kyu , JEON, Jung Ho , CHO, Yo Na , JEONG, Insoon , KWON, Suk Tae , CHA, Sun Shin
IPC: C12N9/12
CPC classification number: C12N9/1252
Abstract: The present invention relates to mutant DNA polymerases and their genes isolated from Thermococcus sp. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NAl. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids sequences, recombinant vectors containing said nucleic acids sequences, host cells transformed with thereof and methods for producing mutant DNA polymerase protein by using thereof. As mutant DNA polymerases according to the present invention have increased processivity by site-specific mutagenesis on exonuclease active site compared to wild type DNA polymerase, the present invention is broadly applicable for PCR in various molecular genetic technologies.
Abstract translation: 本发明涉及从Thermococcus sp。分离的突变型DNA聚合酶及其基因。 更具体地，本发明涉及最初从Thermococcus sp NA1分离的突变型DNA聚合酶。 菌株并通过位点特异性诱变产生，其氨基酸序列，编码所述突变型DNA聚合酶的基因，其核酸序列，含有所述核酸序列的重组载体，用其转化的宿主细胞和通过使用其产生突变型DNA聚合酶蛋白的方法 。 由于本发明的突变型DNA聚合酶与野生型DNA聚合酶相比，通过对外切核酸酶活性位点的位点特异性诱变具有增加的进行性，因此本发明广泛适用于各种分子遗传技术中的PCR。
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公开(公告)号：WO2008041825A1
公开(公告)日：2008-04-10
申请号：PCT/KR2007/004832
申请日：2007-10-02
Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTE , LEE, Jung Hyun , KANG, Sung Gyun , KIM, Sang Jin , KWON, Kae Kyoung , LEE, Hyun Sook , KIM, Yun Jae , BAE, Seung Seob , LIM, Jae Kyu , JEON, Jung Ho , CHO, Yo Na , KWON, Suk Tae
Inventor： LEE, Jung Hyun , KANG, Sung Gyun , KIM, Sang Jin , KWON, Kae Kyoung , LEE, Hyun Sook , KIM, Yun Jae , BAE, Seung Seob , LIM, Jae Kyu , JEON, Jung Ho , CHO, Yo Na , KWON, Suk Tae
CPC classification number: C12N9/1252
Abstract: The present invention relates to mutant DNA polymerases, their genes and their uses. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their ammo acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids and PCR methods by using thereof. As mutant DNA polymerases according to the present invention have decreased proofreading activity and changed function of inosine sensing effectively compared to wild type DNA polymerase, PCR using primers with specific nucleic acids has made rapid progress. Therefore, the present invention is broadly applicable for PCR in various molecular genetic technologies.
Abstract translation: 本发明涉及突变型DNA聚合酶，其基因及其用途。 更具体地，本发明涉及最初从Thermococcus sp NA1分离的突变型DNA聚合酶。 菌株并通过位点特异性诱变产生，其氨基酸序列，编码所述突变型DNA聚合酶的基因，其核酸和通过其使用的PCR方法。 由于与野生型DNA聚合酶相比，根据本发明的突变型DNA聚合酶与野生型DNA聚合酶相比，具有降低的校正活性和肌苷感应功能的改变，所以使用具有特异性核酸的引物的PCR已经取得了快速进展。 因此，本发明广泛适用于各种分子遗传技术中的PCR。
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公开(公告)号：WO2007043769A1
公开(公告)日：2007-04-19
申请号：PCT/KR2006/003988
申请日：2006-10-02
Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTE , LEE, Jung Hyun , KWON, Suk Tae , KANG, Sung Gyun , KIM, Sang Jin , HYUN, Jung Ho , KWON, Kae Kyoung , KIM, Yun Jae , LEE, Hyun Sook , BAE, Seung Seob , NAM, Ki Hoon , LIM, Jae Kyu , JEON, Jung Ho , YANG, Sung Hyun
Inventor： LEE, Jung Hyun , KWON, Suk Tae , KANG, Sung Gyun , KIM, Sang Jin , HYUN, Jung Ho , KWON, Kae Kyoung , KIM, Yun Jae , LEE, Hyun Sook , BAE, Seung Seob , NAM, Ki Hoon , LIM, Jae Kyu , JEON, Jung Ho , YANG, Sung Hyun
CPC classification number: C12N9/1252
Abstract: The present invention relates to a hyperthermophilic DNA polymerase and a preparation method thereof. The invention provides a novel hyperthermophilic DNA polymerase isolated from a Thermococcus sp. strain, a functional equivalent thereof, a protein having the amino acid sequence thereof, and a preparation method thereof. The DNA polymerase according to the invention is a DNA polymerase, which is hyperthermophilic and has an elongation ability and fidelity higher than those of prior commercial DNA polymerases. Thus, the DNA polymerase according to the invention will be useful in precision analysis, precision diagnosis, identification and the like, which require accurate PCR.
Abstract translation: 本发明涉及一种超嗜热DNA聚合酶及其制备方法。 本发明提供了从Thermococcus sp。分离的新型超嗜热DNA聚合酶。 菌株，其功能等同物，具有其氨基酸序列的蛋白质及其制备方法。 根据本发明的DNA聚合酶是DNA聚合酶，其是超嗜热的，并且具有比以前的商业DNA聚合酶更高的伸长能力和保真度。 因此，根据本发明的DNA聚合酶可用于需要精确PCR的精密分析，精确诊断，鉴定等中。
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7.发明申请NOVEL HYDROGENASE ISOLATED FROM THERMOCOCCUS SP., GENE ENCODING THE SAME, AND METHOD FOR PRODUCING HYDROGEN USING MICROORGANISMS WITH THE GENE 审中-公开从热休克菌属分离的新氢化酶，编码该菌株的基因，以及使用该基因的微生物生产氢的方法
公开(公告)号：WO2010027233A2
公开(公告)日：2010-03-11
申请号：PCT/KR2009005060
申请日：2009-09-07
Applicant: KOREA OCEAN RES & DEV I , LEE JUNG HYUN , KANG SUNG GYUN , LEE HYUN SOOK , KIM SANG JIN , KWON KAE KYOUNG , CHA SUN SHIN , JEON JUNG HO , CHO YONA , KIM YUN JAE , BAE SEUNG SEOP , LIM JAE KYU , JEONG IN SOON , LHO TAE OK
Inventor： LEE JUNG HYUN , KANG SUNG GYUN , LEE HYUN SOOK , KIM SANG JIN , KWON KAE KYOUNG , CHA SUN SHIN , JEON JUNG HO , CHO YONA , KIM YUN JAE , BAE SEUNG SEOP , LIM JAE KYU , JEONG IN SOON , LHO TAE OK
CPC classification number: C12N9/0006 , C12N9/0067 , C12P3/00 , C12R1/01 , Y02P20/132 , Y02P20/52
Abstract: The present invention relates to a novel hydrogenase isolated from a novel hyperthermophilic strain which belongs to Thermococcus sp., a gene encoding the same, and a method for producing hydrogen using the hydrogenase and gene. According to the hydrogen production method of the present invention, a large amount of hydrogen can be generated by only culturing the strain under specific culture conditions. Therefore, the method is economical and efficient compared to a conventional hydrogen production method and is able to produce hydrogen at a high temperature.
Abstract translation: 本发明涉及从属于Thermococcus sp。的新型超嗜热菌株分离的新型氢化酶，编码其的基因以及使用该氢化酶和基因产生氢的方法。 根据本发明的氢生产方法，通过仅在特定培养条件下培养菌株可以产生大量的氢。 因此，与传统的氢气生产方法相比，该方法经济并且高效，并且能够在高温下产生氢气。
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