公开(公告)号：WO2006035237A3

公开(公告)日：2006-04-06

申请号：PCT/GB2005/003756

申请日：2005-09-29

Applicant: PROTEOME SCIENCES PLC ,  KING'S COLLEGE LONDON ,  WESTBROOK, Jules ,  BYERS, Helen ,  WARD, Malcolm ,  LOVESTONE, Simon ,  HYE, Abdul ,  LYNHAM, Stephen ,  JOUBERT, Richard ,  PREFOT, Petra ,  KUHN, Karsten ,  BAUMANN, Christian ,  SCHAEFER, Juergen ,  PRINZ, Thorsten ,  KIENLE, Stefan

Inventor： WESTBROOK, Jules ,  BYERS, Helen ,  WARD, Malcolm ,  LOVESTONE, Simon ,  HYE, Abdul ,  LYNHAM, Stephen ,  JOUBERT, Richard ,  PREFOT, Petra ,  KUHN, Karsten ,  BAUMANN, Christian ,  SCHAEFER, Juergen ,  PRINZ, Thorsten ,  KIENLE, Stefan

IPC: G01N33/68 ,  A61P25/28

Abstract: Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

公开(公告)号：WO2006035237A2

公开(公告)日：2006-04-06

申请号：PCT/GB2005003756

申请日：2005-09-29

Applicant: PROTEOME SCIENCES PLC ,  KING S COLLEGE LONDON ,  WESTBROOK JULES ,  BYERS HELEN ,  WARD MALCOLM ,  LOVESTONE SIMON ,  HYE ABDUL ,  LYNHAM STEVEN ,  JOUBERT RICHARD ,  PREFOT PETRA ,  KUHN KARSTEN ,  BAUMANN CHRISTIAN ,  SCHAEFER JUERGEN ,  PRINZ THORSTEN ,  KIENLE STEFAN

Inventor： WESTBROOK JULES ,  BYERS HELEN ,  WARD MALCOLM ,  LOVESTONE SIMON ,  HYE ABDUL ,  LYNHAM STEVEN ,  JOUBERT RICHARD ,  PREFOT PETRA ,  KUHN KARSTEN ,  BAUMANN CHRISTIAN ,  SCHAEFER JUERGEN ,  PRINZ THORSTEN ,  KIENLE STEFAN

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2800/2821 ,  G01N2800/52

Abstract: Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

Abstract translation: 提供了与阿尔茨海默病有关的方法和组合物。 具体而言，提供了相对于其在正常状态中的表达而在阿尔茨海默病状态中差异表达的蛋白质。 确定并描述与阿尔茨海默病有关的蛋白质。 还提供了使用差异表达蛋白诊断阿尔茨海默病的方法，以及用于预防和治疗阿尔茨海默病的化合物的鉴定和治疗用途的方法。