利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

76 条记录 (耗时 0.031 秒)

    COINCIDENCE DETECTION
    2.
    发明申请
    COINCIDENCE DETECTION 审中-公开
    联合检测

    公开(公告)号：WO2011161420A3

    公开(公告)日：2012-05-10

    申请号：PCT/GB2011000953

    申请日：2011-06-23

    申请人： KING S COLLEGE LONDON ,  PARKER PETER ,  PERANI MICHELA

    发明人： PARKER PETER ,  PERANI MICHELA

    IPC分类号： C07K14/72 ,  C12N15/62 ,  G01N33/68

    CPC分类号： C12Q1/6813 ,  C07K16/2863 ,  C07K2319/80 ,  C12N15/1055 ,  C12N15/62 ,  C12Q1/68 ,  C12Q1/6804 ,  G01N33/6842 ,  G01N33/6845 ,  C12Q2522/101 ,  C12Q2531/113 ,  C12Q2531/125

    摘要： The invention relates to a method of detecting the coincidence of two biomolecular structures in a solid phase sample, said method comprising: (i) providing a first and a second fusion protein, each fusion protein comprising (a) a detection domain, said detection domain comprising a DNA binding domain; said detection domain capable of binding a cognate specific nucleotide sequence in co-operation with a further detection domain; (b) a recognition domain, said recognition domain capable of binding a target biomolecular structure; and (c) a connector domain; said connector domain being fused at one end to the detection domain and being fused at the other end to the recognition domain; wherein at least two of (a), (b) and (c) are heterologous to one another; wherein the recognition domains of said first and said second fusion proteins are capable of binding to first and second biomolecular structures; (ii) contacting the sample with said first and second fusion proteins; (iii) incubating to allow binding; (iv) removing unbound fusion protein; (v) contacting the sample with nucleic acid comprising said cognate specific nucleotide sequence; (vi) incubating to allow heterotrimeric binding of the nucleic acid; (vii) detecting nucleic acid bound to the sample wherein detection of nucleic acid in step; (vii) indicates that the two biomolecular structures are present coincidentally in said sample.

    摘要翻译： 本发明涉及一种检测固相样品中两种生物分子结构重合的方法，所述方法包括：（i）提供第一和第二融合蛋白，每种融合蛋白包含（a）检测结构域，所述检测结构域 包括DNA结合结构域; 所述检测结构域能够与另一检测域合用来结合同源特异性核苷酸序列; （b）识别结构域，所述识别结构域能够结合目标生物分子结构; 和（c）连接器领域; 所述连接器域在一端融合到检测域并在另一端融合到识别结构域; 其中（a），（b）和（c）中的至少两个彼此是异源的; 其中所述第一和第二融合蛋白的识别结构域能够结合第一和​​第二生物分子结构; （ii）使样品与所述第一和第二融合蛋白接触; （iii）孵育以允许结合; （iv）去除未结合的融合蛋白; （v）使样品与包含所述同源特异性核苷酸序列的核酸接触; （vi）孵育以允许核酸的异三聚体结合; （vii）检测与样品结合的核酸，其中步骤中检测核酸; （vii）表示两个生物分子结构巧合地存在于所述样品中。

    METHODS
    3.
    发明申请
    METHODS 审中-公开
    方法

    公开(公告)号：WO2010084327A3

    公开(公告)日：2010-09-23

    申请号：PCT/GB2010000107

    申请日：2010-01-26

    申请人： ELECTROPHORETICS LTD ,  KING S COLLEGE LONDON ,  LOVESTONE SIMON HAROLD ,  CAMPBELL JAMES ,  O'BRIEN DARRAGH PATRICK WILLIAM ,  GUENTERT ANDREAS CHRISTIAN ,  BYERS HELEN LOUISE

    发明人： LOVESTONE SIMON HAROLD ,  CAMPBELL JAMES ,  O'BRIEN DARRAGH PATRICK WILLIAM ,  GUENTERT ANDREAS CHRISTIAN ,  BYERS HELEN LOUISE

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6896 ,  G01N2800/2821

    摘要： The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the amount of gelsolin present in said sample to a reference amount of gelsolin present in a sample from a healthy subject,, wherein detection of a gelsolin level in the sample from said patient which is lower than the gelsolin level in the reference sample indicates an increased likelihood of Alzheimer's disease in said patient. Other markers are Cl protease inhibitor and ceruloplasmin. Both blood samples and tissue samples have been investigated.

    摘要翻译： 本发明提供了一种帮助受试者中阿尔茨海默病的诊断或预后监测的方法，所述方法包括： 提供从所述患者获得的血液样品; 测定所述样品中存在的凝溶胶蛋白的量; 将所述样品中存在的凝溶胶蛋白的量与来自健康受试者的样品中存在的参考量的凝溶胶蛋白进行比较，其中来自所述患者的样品中的凝溶胶蛋白水平低于参考样品中的凝溶胶蛋白水平，表明 在所述患者中增加阿尔茨海默病的可能性。 其他标记物是Cl蛋白酶抑制剂和血浆铜蓝蛋白。 血液样本和组织样本均已被调查。

    METHOD
    4.
    发明申请
    METHOD 审中-公开
    方法

    公开(公告)号：WO2009007685A2

    公开(公告)日：2009-01-15

    申请号：PCT/GB2008002276

    申请日：2008-07-02

    申请人： KING S COLLEGE LONDON ,  COMMISSARIAT ENERGIE ATOMIQUE ,  LATHROP MARK ,  THEIN SWAY LAY

    发明人： LATHROP MARK ,  THEIN SWAY LAY

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention relates, in one aspect, to a method for determining the severity of a disease attributed to at least one genetic mutation in one or more of the genes encoding haemoglobin polypeptide chains, comprising the steps of: (a) providing a sample from said subject; and (b) determining the presence of one or more diagnostic markers: (i) within a 127kb segment on chromosome 2pl5; (ii) within MYB and/or HBSIL and/or the intergenic region between MYB and HBSIL located on the 6q23 QTL interval; and/or (iii) within one of the chromosomal loci given in Table 14; wherein the presence of said marker(s) in said sample is indicative that the severity of said disease in said subject will be or is less severe in said subject in comparison to a subject that does not possess said marker(s).

    摘要翻译： 一方面，本发明涉及用于确定归因于编码血红蛋白多肽链的一个或多个基因中的至少一个基因突变的疾病严重性的方法，其包括以下步骤：（a）提供来自 说的话题; 和（b）确定一种或多种诊断标记的存在：（i）在染色体2p15上的127kb片段内; （ii）MYB和/或HBSIL内和/或位于6q23 QTL区间的MYB和HBSIL之间的基因间区域; 和/或（iii）在表14中给出的一个染色体基因座内; 其中所述样品中所述标志物的存在表明所述受试者中所述疾病的严重程度与不具有所述标志物的受试者相比将在所述受试者中或者不太严重。

    A METHOD OF MAPPING A FIRST INTERFACE TO A SECOND INTERFACE, AND PEOPLE PRESENCE ESTIMATION METHOD
    6.
    发明申请
    A METHOD OF MAPPING A FIRST INTERFACE TO A SECOND INTERFACE, AND PEOPLE PRESENCE ESTIMATION METHOD 审中-公开
    将第一接口映射到第二接口的方法和人存在估计方法

    公开(公告)号：WO2006008559A3

    公开(公告)日：2006-06-08

    申请号：PCT/GB2005050117

    申请日：2005-07-25

    申请人： KING S COLLEGE LONDON ,  AGHVAMI ABDOL HAMID ,  PANGALOS PAUL ANTHONY ,  FRIDERIKOS VASILIS ATHANASIOS ,  DOHLER MICHAEL

    发明人： AGHVAMI ABDOL HAMID ,  PANGALOS PAUL ANTHONY ,  FRIDERIKOS VASILIS ATHANASIOS ,  DOHLER MICHAEL

    IPC分类号： H04L29/12 ,  H04L12/24 ,  H04L12/28

    CPC分类号： H04W48/18 ,  H04W88/06

    摘要： A method of mapping a first interface to a second interface both of an electronic data communication device (16), which first interface enables exchange of data with a first electronic data communication network (13) and which second interface enables exchange of data with a second electronic data communication network (12), the method comprising the steps of: (1) obtaining an address representative of said first interface; (2) generat ing an identifier; (3) storing said identifier and said address representative of said first interface in a memory with a mapping therebetween; (4) outputting said identifier; (5) awaiting receipt of data comprising said identifier and an address representative of said second interface from said electronic data communication device (16) via said second electronic data communication network (12); and (6) if said data is received, said identifier can be used to map said address representative of said first interface to said address representative of said second interface. A method of estimating the number of people within a predetermined range of a particular location, which method comprises the steps of: - (a) using an antenna to listen for electromagnetic communication signals indicative of the presence of one or more remote electronic data communication device likely to be carried about the person of one or more of said people; and (b) providing an electronic output signal from said antenna representative of said presence; which electronic output signal facilitates estimation of the number of people within said predetermined range.

    摘要翻译： 一种将第一接口映射到电子数据通信设备（16）的第二接口的方法，所述电子数据通信设备（16）的第一接口允许与第一电子数据通信网络（13）进行数据交换，以及哪个第二接口能够与第二接口进行数据交换 电子数据通信网络（12），所述方法包括以下步骤：（1）获得所述第一接口的代表地址; （2）生成标识符; （3）将所述标识符和表示所述第一接口的所述地址存储在存储器中，其间具有映射; （4）输出所述识别符; （5）经由所述第二电子数据通信网络（12）等待从所述电子数据通信设备（16）接收包括所述标识符的数据和表示所述第二接口的地址; 和（6）如果接收到所述数据，则所述标识符可用于将表示所述第一接口的所述地址映射到所述第二接口的所述地址。 一种估计特定位置的预定范围内的人数的方法，所述方法包括以下步骤： - （a）使用天线监听指示一个或多个远程电子数据通信设备的存在的电磁通信信号 可能会涉及一个或多个所述人的人; 和（b）从所述天线提供代表所述存在的电子输出信号; 该电子输出信号有助于估计所述预定范围内的人数。

    MAGNETIC RESONANCE IMAGING FOR INTERVENTIONAL PROCEDURES
    8.
    发明申请
    MAGNETIC RESONANCE IMAGING FOR INTERVENTIONAL PROCEDURES 审中-公开
    用于传统程序的磁共振成像

    公开(公告)号：WO2005109024A1

    公开(公告)日：2005-11-17

    申请号：PCT/IB2005/051383

    申请日：2005-04-28

    申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  KING`S COLLEGE LONDON ,  KOZERKE, Sebastian ,  RAZAVI, Reza ,  HILL, Derek, L., G. ,  HEGDE, Sanjeet, R.

    发明人： KOZERKE, Sebastian ,  RAZAVI, Reza ,  HILL, Derek, L., G. ,  HEGDE, Sanjeet, R.

    IPC分类号： G01R33/28

    CPC分类号： G01R33/287

    摘要： Two different RF-frequency ranges or bands are employed viz. at the localisation RF-frequency and at the imaging RF-frequency, respectively. At these respective RF-frequency ranges different types of magnetic resonance signals are acquired. At the localisation RF-frequency a high sensitivity for the position of the interventional device is achieved. At the imaging RF-frequency a high sensitivity for image information, i.e. contrast resolution, of the anatomical structures of the patient to be examined is achieved.

    摘要翻译： 使用两个不同的RF频率范围或频带。 分别在定位RF频率和成像RF频率。 在这些各个RF频率范围内，获得不同类型的磁共振信号。 在定位RF频率下，实现了介入装置位置的高灵敏度。 在成像RF频率下，实现了要检查的患者的解剖结构的图像信息（即对比度分辨率）的高灵敏度。

    IMAGE ENHANCEMENT
    9.
    发明申请
    IMAGE ENHANCEMENT 审中-公开
    图像增强

    公开(公告)号：WO0205212A3

    公开(公告)日：2003-03-13

    申请号：PCT/GB0103127

    申请日：2001-07-11

    申请人： KING S COLLEGE LONDON ,  PIKE EDWARD ROY ,  CHANA DEEPH ,  MCNALLY BEN

    发明人： PIKE EDWARD ROY ,  CHANA DEEPH ,  MCNALLY BEN

    IPC分类号： G06T5/00

    CPC分类号： G06T5/003 ,  G06T2207/10088

    摘要： A method of deblurring images e.g. from an MRI scan, comprises calculating the distribution of the slope value of the intensities between the pixels in the image, and using a Levy distribution of power factor k of 1 (Cauchy distribution) up to but not inc luding (2) to determine the correction term to be applied.

    摘要翻译： 一种去除图像的方法，例如 从MRI扫描中，包括计算图像中的像素之间的强度的斜率值的分布，并且使用功率因数k为1（柯西分布）的Levy分布直到但不包括（2）来确定 修正术语适用。