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    ULTRASONIC TREATMENT OF VITREOUS OPACITIES
    1.
    发明申请
    ULTRASONIC TREATMENT OF VITREOUS OPACITIES 审中-公开

    公开(公告)号：WO2022040493A1

    公开(公告)日：2022-02-24

    申请号：PCT/US2021/046819

    申请日：2021-08-20

    Applicant: YAU, Gary Lloyd Ka Tao ,  HYNYNEN, Kullervo Henrik

    Inventor： YAU, Gary Lloyd Ka Tao ,  HYNYNEN, Kullervo Henrik

    IPC: A61F9/00 ,  A61N7/02

    Abstract: In at least some examples, a method of treating an eye, includes (i) imaging a patient's vitreous using a probe, (ii) defining a window on a desired region of the vitreous, (iii) administering ultrasonic energy treatment to the desired region within the window, (iv) continually monitoring the treatment via the probe, (v) adjusting a characteristic of the ultrasonic energy treatment based on the monitoring, (vi) re-imaging the desired region of the vitreous after the treatment is administered, and (vii) evaluating or observing the desired region to determine whether a target percentage of a vitreous opacity has been resolved.

    SHEAR MODE DIAGNOSTIC ULTRASOUND
    3.
    发明申请
    SHEAR MODE DIAGNOSTIC ULTRASOUND 审中-公开
    剪切模式诊断超声波

    公开(公告)号：WO2004093686A1

    公开(公告)日：2004-11-04

    申请号：PCT/US2004/011374

    申请日：2004-04-12

    Applicant: THE BRIGHAM & WOMEN'S HOSPITAL, INC. ,  HYNYNEN, Kullervo ,  CLEMENT, Gregory, T.

    Inventor： HYNYNEN, Kullervo ,  CLEMENT, Gregory, T.

    IPC: A61B8/00

    CPC classification number: A61N7/02 ,  A61B8/06 ,  A61B8/0808 ,  A61B8/485 ,  A61B8/54 ,  A61B17/22004 ,  A61N2007/0065 ,  A61N2007/0095

    Abstract: A method of diagnosing a subject by delivering ultrasound signals using shear waves includes applying a portion of an ultrasound mainbeam to a bone surface at an incident angle relative to the surface of the bone to induce shear waves in the bone, energy in the shear waves forming a substantial part of energy of first ultrasound waves at a desired region in the subject through the bone, detecting at least one of reflected and scattered energy of the applied ultrasound mainbeam, and analyzing the detected energy for a diagnostic purpose.

    Abstract translation: 通过使用剪切波输送超声信号来诊断受试者的方法包括以相对于骨表面的入射角将一部分超声波主干施加到骨表面，以引起骨中的剪切波，形成剪切波中的能量 通过骨骼在受试者的期望区域上的第一超声波的大部分能量，检测所施加的超声波主波束的反射和散射能量中的至少一个，并且将检测到的能量分析用于诊断目的。

    APERIODIC ULTRASOUND PHASED ARRAY
    4.
    发明申请
    APERIODIC ULTRASOUND PHASED ARRAY 审中-公开
    APERIODIC超声波相位阵列

    公开(公告)号：WO1997017018A1

    公开(公告)日：1997-05-15

    申请号：PCT/US1996017964

    申请日：1996-11-08

    Applicant: BRIGHAM & WOMEN'S HOSPITAL ,  HUTCHINSON, Erin ,  BUCHANAN, Mark ,  HYNYNEN, Kullervo

    Inventor： BRIGHAM & WOMEN'S HOSPITAL

    IPC: A61B08/00

    CPC classification number: B06B1/0633 ,  A61B2017/22028 ,  A61M37/0092 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0095 ,  B06B1/0622 ,  B06B1/0629

    Abstract: An apparatus (10) for providing ultrasonic energy for deposition in body tissue (24) including an array (17) of elements (18, 20) having at least two different sizes and at least one element being periodically spaced with respect to the other elements in the array. An amplifier system (12) includes amplifiers (15), and phase shifters (16) each individually controlling each of the elements producing a beam of ultrasonic energy having reduced grating lobes. Reduced grating lobe magnitude permits improved ultrasonic beam focusing and/or the use of larger element sizes.

    Abstract translation: 一种用于提供用于沉积在身体组织（24）中的超声能量的装置（10），包括具有至少两种不同尺寸的元件（18,20）的阵列（17），并且至少一个元件相对于其它元件周期性间隔开 在阵列中。 放大器系统（12）包括放大器（15）和移相器（16），每个单独地控制每个元件产生具有减小的栅瓣的超声能量束。 减小的光栅大小允许改进的超声波束聚焦和/或使用更大的元件尺寸。

    SYSTEMS AND METHODS FOR SUPER-RESOLUTION ULTRASOUND IMAGING
    5.
    发明申请
    SYSTEMS AND METHODS FOR SUPER-RESOLUTION ULTRASOUND IMAGING 审中-公开
    超分辨超声成像的系统与方法

    公开(公告)号：WO2014179681A1

    公开(公告)日：2014-11-06

    申请号：PCT/US2014/036567

    申请日：2014-05-02

    Applicant: SUNNYBROOK HEALTH SCIENCES CENTRE ,  HYNYNEN, Kullervo ,  O'REILLY, Meaghan ,  FOROOZAN, Foroohar

    Inventor： HYNYNEN, Kullervo ,  O'REILLY, Meaghan ,  FOROOZAN, Foroohar

    IPC: A61B8/08

    CPC classification number: A61B8/5238 ,  A61B8/0808 ,  A61B8/0891 ,  A61B8/4494 ,  A61B8/481 ,  A61B8/5207 ,  A61B8/5246 ,  A61B8/54 ,  G01S7/52039 ,  G01S7/52047 ,  G01S7/52049 ,  G01S15/8922 ,  G01S15/8929

    Abstract: Systems and methods for ultrasound imaging capable of achieving spatial resolutions that can resolve objects smaller than 300 μιη are described. Ultrasound is transmitted to and steered over a volume-of-interest that contains a microbubble contrast agent to individually excite microbubbles. Signal data is acquired in response to the transmitted ultrasound, and a plurality of images are reconstructed by beamforming the acquired signal data. The spatial resolution of the beamformed images can be further increased using techniques that determine the position of the microbubble within each image to a greater level of accuracy than the point spread function ("PSF") of the ultrasound system. The images can also be combined to produce a single high resolution image of the volume-of-interest using, for instance, a maximum pixel projection technique.

    Abstract translation: 超声成像的系统和方法能够实现可以解决小于300微米的物体的空间分辨率; 被描述。 将超声波传输到包含微泡造影剂的感兴趣体积并引导，以单独激发微泡。 响应于所发送的超声波获取信号数据，并且通过对获取的信号数据进行波束成形来重建多个图像。 可以使用将超声系统的点扩散函数（“PSF”）确定每个图像内的微泡的位置的精度更高的技术来进一步增加波束形成的图像的空间分辨率。 也可以使用例如最大像素投影技术来组合图像以产生感兴趣体积的单个高分辨率图像。

    ULTRASOUND TRANSDUCER AND METHOD FOR MAKING THE SAME
    7.
    发明申请
    ULTRASOUND TRANSDUCER AND METHOD FOR MAKING THE SAME 审中-公开
    超声波传感器及其制造方法

    公开(公告)号：WO2013043906A1

    公开(公告)日：2013-03-28

    申请号：PCT/US2012/056393

    申请日：2012-09-20

    Applicant: SUNNYBROOK HEALTH SCIENCES CENTRE ,  HYNYNEN, Kullervo ,  SONG, Junho

    Inventor： HYNYNEN, Kullervo ,  SONG, Junho

    IPC: H01L41/083

    CPC classification number: B06B1/0622 ,  A61B8/4488 ,  A61N7/02 ,  H01L41/0475 ,  H01L41/29 ,  Y10T29/49005

    Abstract: The present application provides a multilayer lateral mode coupling method for phased array construction and transducer devices built accordingly. This disclosure describes and demonstrates that the electrical impedance of a phased array can be substantially reduced and readily controlled to be close to the source impedance. The fabrication process is relatively simple and inexpensive. In addition, the elements are robust for use in 1.5, 2, 3 or other dimensional configurations, over an extended period of operation, without structural failure, and providing a high power output required for imaging and/or medical therapy applications.

    Abstract translation: 本申请提供了相位阵列构造的多层横向耦合方法和相应地构建的换能器装置。 本公开描述并证明相控阵列的电阻抗可以被显着地减少并容易控制为接近源阻抗。 制造工艺相对简单和便宜。 此外，这些元件在1.5,2,3或其他尺寸配置中是稳健的，在延长的操作期间，没有结构故障，并且提供成像和/或医疗治疗应用所需的高功率输出。

    FOCUSED ULTRASOUND SYSTEM
    8.
    发明申请
    FOCUSED ULTRASOUND SYSTEM 审中-公开
    聚焦超声系统

    公开(公告)号：WO2010057067A3

    公开(公告)日：2010-08-12

    申请号：PCT/US2009064506

    申请日：2009-11-16

    Applicant: SUNNYBROOK HEALTH SCIENCES CT ,  CHOPRA RAJIV ,  HYNYNEN KULLERVO ,  CHAU ANTHONY ,  WASPE ADAM CHRISTIAN

    Inventor： CHOPRA RAJIV ,  HYNYNEN KULLERVO ,  CHAU ANTHONY ,  WASPE ADAM CHRISTIAN

    IPC: A61B8/00 ,  A61B5/055

    CPC classification number: A61N7/02 ,  A61B8/0816 ,  A61B34/70 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/0084 ,  A61B2090/374 ,  A61N2007/0082

    Abstract: A focused ultrasound system includes an ultrasound transducer configured to emit focused ultrasound energy toward a subject and a positioning system configured to position the ultrasound transducer to localize the focused ultrasound energy within a target location. The positioning system includes a drive apparatus to translate the ultrasound transducer along at least one axis of motion and a motor controller to control the drive apparatus. The focused ultrasound system also includes a control system connected to the motor controller that is programmed to receive imaging/location data from an imaging system, determine positional coordinates of the target location based on the imaging/location data, and register the positional coordinates of the target location with the positioning system. The positional coordinates are sent to the motor controller via an input signal to cause the motor controller to control the drive apparatus so as to translate the ultrasound transducer.

    Abstract translation: 聚焦超声系统包括配置成朝向受试者发射聚焦的超声能量的超声换能器和配置成定位超声换能器以定位目标位置内的聚焦超声能量的定位系统。 定位系统包括驱动装置，用于沿着至少一个运动轴平移超声波换能器和马达控制器以控制驱动装置。 聚焦超声系统还包括连接到电动机控制器的控制系统，其被编程为从成像系统接收成像/位置数据，基于成像/位置数据确定目标位置的位置坐标，并且记录 目标位置与定位系统。 位置坐标通过输入信号发送到电动机控制器，使得电动机控制器控制驱动装置以便平移超声换能器。

    ULTRASOUND THERAPY TRANSDUCER HEAD AND ULTRASOUND THERAPY SYSTEM INCORPORATING THE SAME
    9.
    发明申请
    ULTRASOUND THERAPY TRANSDUCER HEAD AND ULTRASOUND THERAPY SYSTEM INCORPORATING THE SAME 审中-公开
    超声波治疗头和超声波治疗系统

    公开(公告)号：WO2010025549A1

    公开(公告)日：2010-03-11

    申请号：PCT/CA2009/001214

    申请日：2009-09-08

    Applicant: SUNNYBROOK HEALTH SCIENCES CENTRE ,  HYNYNEN, Kullervo H. ,  SONG, Junho

    Inventor： HYNYNEN, Kullervo H. ,  SONG, Junho

    IPC: A61N7/00 ,  A61N7/02

    CPC classification number: A61N7/02 ,  A61B8/546 ,  A61B2018/00011 ,  A61B2018/00642 ,  A61N2007/0078 ,  B06B3/00

    Abstract: An ultrasound therapy transducer head (10) comprises an ultrasound source (14) emitting ultrasonic radiation, the ultrasound source comprising a plurality of transducer elements (20), integrated driving electronics (24) coupled to the transducer elements, the electronics generating at least one output ultrasound waveform and driving at least some of the transducer elements independently based on the at least one output ultrasound waveform and temperature control structure providing cooling for the electronics.

    Abstract translation: 一种超声治疗换能器头（10）包括发射超声辐射的超声波源（14），所述超声波源包括耦合到所述换能器元件的多个换能器元件（20），所述集成驱动电子器件（24），所述电子元件产生至少一个 输出超声波形，并基于所述至少一个输出超声波形和温度控制结构独立地驱动至少一些所述换能器元件，为所述电子设备提供冷却。

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