公开(公告)号：WO2010014628A2

公开(公告)日：2010-02-04

申请号：PCT/US2009051986

申请日：2009-07-28

Applicant: INCUBE LABS LLC ,  IMARAN MIR

Inventor： IMARAN MIR

IPC: A61B17/12 ,  A61F2/06 ,  A61L27/14

CPC classification number: A61B17/1114 ,  A61B17/11 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61B2017/1103 ,  A61B2017/1107 ,  A61B2017/1117 ,  A61B2017/1132 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61B2090/0807 ,  A61F2/04 ,  A61F2/064 ,  A61F2/848 ,  A61F2002/044 ,  A61F2002/072 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2210/0004 ,  A61F2250/0018 ,  A61F2250/0069

Abstract: Embodiments of the invention provide systems and methods for using a tissue scaffold to facilitate healing of an anastomosis. One embodiment provides a tissue scaffold for placement at an anastomotic site within a body lumen comprising a radially expandable scaffold structure having lateral and mid portions, at least one retention element coupled to each lateral portion and a barrier layer. The retention element engages a luminal wall when the scaffold structure is expanded to retain the structure and exert a compressive force on the anastomosis. The mid portion has a greater radial stiffness than the lateral portions such that when the structure is expanded, the lateral portions engage tissue prior to the mid portion. The barrier layer is configured to engage a luminal wall when the structure is expanded to provide a fluidic seal at the anastomosis. The barrier layer may also include releasable biological agents to promote anastomotic healing.

Abstract translation: 本发明的实施方案提供了使用组织支架以促进吻合愈合的系统和方法。 一个实施例提供了一种用于放置在体腔内的吻合部位的组织支架，其包括具有侧向和中间部分的径向可扩展的支架结构，至少一个连接到每个侧向部分和阻挡层的保持元件。 当支架结构膨胀以保持结构并且在吻合上施加压缩力时，保持元件与腔壁接合。 中部具有比侧部更大的径向刚度，使得当结构膨胀时，侧部在中间部分之前接合组织。 当结构被扩张以在吻合处提供流体密封时，阻挡层被构造成与腔壁接合。 阻挡层还可以包括可释放的生物制剂以促进吻合愈合。

公开(公告)号：WO2010014628A3

公开(公告)日：2010-02-04

申请号：PCT/US2009/051986

申请日：2009-07-28

Applicant: INCUBE LABS, LLC ,  IMARAN, Mir

Inventor： IMARAN, Mir

IPC: A61F2/04 ,  A61B17/12 ,  A61L27/14

Abstract: Embodiments of the invention provide systems and methods for using a tissue scaffold to facilitate healing of an anastomosis. One embodiment provides a tissue scaffold for placement at an anastomotic site within a body lumen comprising a radially expandable scaffold structure having lateral and mid portions, at least one retention element coupled to each lateral portion and a barrier layer. The retention element engages a luminal wall when the scaffold structure is expanded to retain the structure and exert a compressive force on the anastomosis. The mid portion has a greater radial stiffness than the lateral portions such that when the structure is expanded, the lateral portions engage tissue prior to the mid portion. The barrier layer is configured to engage a luminal wall when the structure is expanded to provide a fluidic seal at the anastomosis. The barrier layer may also include releasable biological agents to promote anastomotic healing.