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公开(公告)号：WO2020014306A1
公开(公告)日：2020-01-16
申请号：PCT/US2019/041128
申请日：2019-07-10
Applicant: IMMUNOGEN, INC.
Inventor： HICKS, Stuart, William , LAI, Katharine, C.
Abstract: MET is a receptor tyrosine kinase found on the surface of tumor cells. The present invention includes anti-MET antibodies, forms and fragments, having superior physical and functional properties; immunoconjugates, compositions, diagnostic reagents, methods for inhibiting growth, therapeutic methods, improved antibodies and cell lines; and polynucleotides, vectors and genetic constructs encoding same.
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公开(公告)号：WO2019222130A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/032090
申请日：2019-05-14
Applicant: IMMUNOGEN, INC.
Inventor： WALKER, Russell , WATKINS, Krystal , ZWEIDLER-MCKAY, Patrick
IPC: A61K39/395 , C07K16/28 , C07K16/30 , A61K31/4188 , A61K31/422 , A61K31/5377 , A61K47/68
Abstract: The present invention provides a method of treating a cancer in a subject comprising administering to the subject a therapeutically effective amount of a CD33 -targeted antibody- drug conjugate (ADC) and a therapeutically effective amount of quizartinib or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions comprising a therapeutically effective amount of a CD33 -targeted ADC and a therapeutically effective amount of quizartinib or a pharmaceutically acceptable salt thereof.
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公开(公告)号：WO2019050935A1
公开(公告)日：2019-03-14
申请号：PCT/US2018/049529
申请日：2018-09-05
Applicant: IMMUNOGEN, INC.
Inventor： XU, Raymond , CULM-MERDEK, Kerry
IPC: G01N33/53 , G01N33/566 , G01N33/68
Abstract: The invention generally relates to methods and kits for the detection of human folate receptor 1 in a sample. Peptides of human folate receptor 1 are further provided.
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公开(公告)号：WO2018213260A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/032692
申请日：2018-05-15
Applicant: IMMUNOGEN, INC. , MERCK SHARP & DOHME CORP.
Inventor： RUIZ SOTO, Rodrigo R.
IPC: C07K16/28 , A61K39/395
Abstract: Therapeutic combinations of immunoconjugates that bind to FOLR1 ( e.g ., IMGN853) with anti-PD-1 antibodies or antigen-binding fragments thereof ( e.g ., pembrolizumab) are provided. Methods of administering the combinations to treat cancers, e.g ., ovarian, peritoneal, or fallopian tube cancers, with greater clinical efficacy and/or decreased toxicity are also provided.
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公开(公告)号：WO2018160539A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/019874
申请日：2018-02-27
Applicant: IMMUNOGEN, INC.
Inventor： WIDDISON, Wayne, C.
Abstract: The invention relates to novel cell-binding agent-maytansinoid conjugate having a self-immolative peptide linker and more specifically to conjugates of formula (I). The invention also provides novel maytansinoid compounds of formula (II), (III), (IV) or (V). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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Patent Agency Ranking
公开(公告)号：WO2018129029A9
公开(公告)日：2018-07-12
申请号：PCT/US2018/012168
申请日：2018-01-03
Applicant: IMMUNOGEN, INC.
Inventor： CHITTENDEN, Thomas , DECKERT, Jutta , HICKS, Stuart, William , LAI, Katharine, C. , PARK, Peter, U. , RUI, Lingyun , TAVARES, Daniel, J. , KOHLI, Neeraj
Abstract: MET is a receptor tyrosine kinase found on the surface of tumor cells. The present invention includes anti-MET antibodies, forms and fragments, having superior physical and functional properties; immunoconjugates, compositions, diagnostic reagents, methods for inhibiting growth, therapeutic methods, improved antibodies and cell lines; and polynucleotides, vectors and genetic constructs encoding same.
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公开(公告)号：WO2017015496A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043406
申请日：2016-07-21
Applicant: IMMUNOGEN, INC.
Inventor： GÉRARD, Baudouin , SHIZUKA, Manami , MILLER, Michael Louis , SILVA, Richard A.
IPC: C07D487/04
CPC classification number: C07D519/00 , C07D487/04 , C07K5/0804
Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：WO2017015495A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043402
申请日：2016-07-21
Applicant: IMMUNOGEN, INC.
Inventor： GÉRARD, Baudouin , SHIZUKA, Manami , MILLER, Michael, Louis , SILVA, Richard, A.
IPC: C07D487/04
CPC classification number: C07D519/00 , C07D487/04 , C07K5/0804
Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Abstract translation: 本发明涉及制备吲哚并苯并二氮杂二聚体化合物及其合成前体的新方法。
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公开(公告)号：WO2017004026A8
公开(公告)日：2017-01-05
申请号：PCT/US2016/039797
申请日：2016-06-28
Applicant: IMMUNOGEN, INC.
Inventor： KOVTUN, Yelena , TAVARES, Daniel , RUI, Lingyun , CHITTENDEN, Thomas
IPC: C07K16/28 , A61K47/48 , A61K39/395 , A61P35/00
Abstract: The present disclosure generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD 123 antigen (the a chain of the interleukine 3 receptor, or IL-3Ra). The present disclosure also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.
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公开(公告)号：WO2017004026A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/039797
申请日：2016-06-28
Applicant: IMMUNOGEN, INC.
Inventor： KOVTUN, Yelena , TAVARES, Daniel , RUI, Lingyun , CHITTENDEN, Thomas
IPC: C07K16/28 , A61K47/48 , A61K39/395 , A61P35/00
CPC classification number: C07K16/2866 , A61K39/3955 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present disclosure generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD 123 antigen (the a chain of the interleukine 3 receptor, or IL-3Ra). The present disclosure also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.
Abstract translation: 本公开内容通常涉及结合CD123抗原（白细胞介素3受体或IL-3Ra的一条链）的抗体，其抗原结合片段，多肽和免疫缀合物。 本公开还涉及使用这种CD123结合分子来诊断和治疗疾病如B细胞恶性肿瘤的方法。
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