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公开(公告)号:WO2010144773A1
公开(公告)日:2010-12-16
申请号:PCT/US2010/038268
申请日:2010-06-11
申请人: MONELL CHEMICAL SENSES CENTER , BACHMANOV, Alexander, Alexeyevich , BOSAK, Nataliya, Petrovna , ISHIWATARI, Yutaka
CPC分类号: G01N33/5023 , A01K2227/105 , A01K2267/0393 , C12N15/8509 , C12N2830/008 , C12Q1/6897 , G01N33/689 , G01N2500/00
摘要: The present invention relates to a polynucleotide vector comprising the Simian taste-bud specific gene (STG) promoter operatively linked to a reporter gene. In preferred embodiments, the STG promoter is the murine ortholog of the STG promoter. In other preferred embodiments, the STG promoter is the human ortholog of the STG promoter. In some preferred embodiments, the reporter gene is green fluorescent protein (GFP). Additionally provided are vectors comprising the STG promoter operatively linked to a cre-recombinase gene.
摘要翻译: 本发明涉及包含与报告基因有效连接的猿猴味蕾特异性基因(STG)启动子的多核苷酸载体。 在优选的实施方案中,STG启动子是STG启动子的鼠直系同源物。 在其它优选实施方案中,STG启动子是STG启动子的人直向同源物。 在一些优选的实施方案中,报道基因是绿色荧光蛋白(GFP)。 另外提供了包含可操作地连接到重组酶基因的STG启动子的载体。