公开(公告)号：WO2022182805A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/017588

申请日：2022-02-23

Applicant: IVIVA MEDICAL, INC.

Inventor： KLASSEN, Charles, C.

IPC: A61L27/54 ,  A61L27/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/40

Abstract: Disclosed herein is a conduit comprising a tubular structure comprising a porous biocompatible polymer embedded in a biocompatible extracellular matrix material and an internal luminal space, and a method of making the conduit. The conduit is for use in devices such as artificial tissues and organs. The method of making the conduit may comprise providing a tubular structure having an Internal luminal space and comprising a porous biocompatible polymer, perfusing the pores and luminal space of the tubular structure with a first solution, replacing the first solution by perfusing the pores and luminal space of the tubular structure with the aqueous solution comprising liquified extracellular matrix material, and embedding the tubular structure in extracellular matrix material by polymerizing the liquified extracellular matrix material to form the conduit.

公开(公告)号：WO2020176888A1

公开(公告)日：2020-09-03

申请号：PCT/US2020/020498

申请日：2020-02-28

Applicant: IVIVA MEDICAL, INC.

Inventor： KLASSEN, Charles, C. ,  OTT, Harald, C. ,  JARAMILLO, Maria ,  HESSE, Robert, G. ,  CHENG, Daniel

IPC: B01D61/14 ,  A61L27/40 ,  A61M1/16 ,  A61M1/34

Abstract: Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

公开(公告)号：WO2018227026A1

公开(公告)日：2018-12-13

申请号：PCT/US2018/036565

申请日：2018-06-07

Applicant: IVIVA MEDICAL, INC.

Inventor： KLASSEN, Charles, C.

IPC: A61M1/16 ,  A61M1/28

CPC classification number: A61M1/1696 ,  A61M1/287 ,  B01D61/28 ,  B01D63/02 ,  B01D63/06

Abstract: Disclosed are compositions and methods of regenerating or enhancing dialysate. Specifically, provided is a dialysate regeneration or enhancement component having a membrane with luminal spaces on each side wherein dialysate is circulated on one side of the membrane and waste dialysate is circulated on the other side. Renal tubule epithelial cells embedded on the membrane transport water, glucose, electrolytes, amino acids and other beneficial compounds from the waste dialysate across a membrane into unused dialysate, thereby reducing the amount of dialysate needed for peritoneal dialysis or enhancing the dialysate.

公开(公告)号：WO2018112480A1

公开(公告)日：2018-06-21

申请号：PCT/US2017/067141

申请日：2017-12-18

Applicant: IVIVA MEDICAL, INC.

Inventor： KLASSEN, Charles, C.

IPC: C12N5/00 ,  A61L27/14 ,  A61L27/40 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54

Abstract: Disclosed are compositions and methods of making basement membrane constructs having interior or luminal volumes. The interior or luminal volumes may be in the form of vascular networks for liquid (e.g., blood) or gas perfusion. The interior spaces may also contain cells, such as epithelial cells. Also disclosed are tissues and organs, and methods of making thereof, comprising basement membrane constructs.