公开(公告)号：WO2020072463A1

公开(公告)日：2020-04-09

申请号：PCT/US2019/054020

申请日：2019-10-01

Applicant: ELEMENTAL MACHINES, INC. ,  HOE, Liang ,  IYENGAR, Sridhar ,  BYER, Brett ,  MURPHY, Katherine

Inventor： HOE, Liang ,  IYENGAR, Sridhar ,  BYER, Brett ,  MURPHY, Katherine

IPC: G01D21/00 ,  G01D21/02 ,  G06K19/07 ,  G01K1/02 ,  G01K3/04 ,  G06F3/00

Abstract: A sensing system is provided. The system comprises a microprocessor (or computing device) with a memory, means of transmitting information wirelessly, an antenna, a power supply, and a sensor configured to measure at least one environmental parameter.

公开(公告)号：WO2014143495A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/016452

申请日：2014-02-14

Applicant: AGAMATRIX, INC. ,  IYENGAR, Sridhar ,  HARDING, Ian ,  WILLIAMS, Richard ,  CAI, Hua (Kevin)

Inventor： IYENGAR, Sridhar ,  HARDING, Ian ,  WILLIAMS, Richard ,  CAI, Hua (Kevin)

IPC: G01N27/327 ,  G01N33/487

CPC classification number: G01N33/48771 ,  G01N27/3274

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then tanslated into information reflecting a characteristic of the test strip prior to introdution of sample.

Abstract translation: 提供了一种用于获得编码在电化学测试条上的信息的方法。 测试条具有设置在样品空间内的两个电极，并且在引入液体样品之前将该信息编码在测试条上。 该方法包括将样品引入样品空间以使样品与样品空间内的两个电极接触的步骤。 在另一步骤中，确定代表测试条的双层电容和/或测试条的等效电容的值。 然后将确定的值转化为在样品引入之前反映测试条的特征的信息。

公开(公告)号：WO2013101224A1

公开(公告)日：2013-07-04

申请号：PCT/US2011/068227

申请日：2011-12-30

Applicant: INTEL CORPORATION ,  KUMAR, S. Reji ,  IYENGAR, Sridhar R.

Inventor： KUMAR, S. Reji ,  IYENGAR, Sridhar R.

IPC: G06F15/76 ,  G06F9/44 ,  G06F9/22

CPC classification number: G06F9/54 ,  G06F9/455 ,  G06F9/541

Abstract: A hardware/software architecture cars include a high-level software stack on which a plurality of software applications are executing, an underlying hardware platform having a hardware platform type, and a middleware layer residing between the high-level software stack and the underlying hardware platform and configured to allow two or more of the plurality of software applications to interact with each other independent of the hardware platform type.

Abstract translation: 硬件/软件架构汽车包括其上执行多个软件应用的高级软件堆栈，具有硬件平台类型的底层硬件平台以及驻留在高级软件堆栈和底层硬件平台之间的中间件层 并且被配置为允许所述多个软件应用程序中的两个或更多个独立于硬件平台类型彼此交互。

公开(公告)号：WO2009015292A4

公开(公告)日：2009-03-19

申请号：PCT/US2008071075

申请日：2008-07-24

Applicant: AGAMATRIX INC ,  IYENGAR SRIDHAR

Inventor： IYENGAR SRIDHAR

IPC: G01N27/327 ,  C12M1/34 ,  G01N27/26

CPC classification number: G01N27/3272

Abstract: An easily manufactured electrochemical test strip is made with facing electrode but side by side connectors for insertion into an electrochemical test meter. Current is conducted from the electrode on one layer to a connector on the other by a conductive layer disposed adjacent the end of a spacer layer, or by displacing the layer to bring a conductive surface on it into contact with the connector.

Abstract translation: 一种容易制造的电化学测试条由面对电极制成，但是并排连接器用于插入电化学测试仪。 通过邻近间隔层的端部设置的导电层，或通过移动该层以使其上的导电表面与连接器接触，电流从一层上的电极传导到另一层上的连接器。

公开(公告)号：WO2009015077A1

公开(公告)日：2009-01-29

申请号：PCT/US2008/070630

申请日：2008-07-21

Applicant: AGAMATRIX, INC. ,  HARDING, Ian ,  IYENGAR, Sridhar

Inventor： HARDING, Ian ,  IYENGAR, Sridhar

IPC: C12M1/34 ,  C12Q1/00 ,  G01N33/487 ,  G01N27/327

CPC classification number: G01N27/3272 ,  C12Q1/001

Abstract: An electrochemical test strip is formed from a first insulating substrate layer, a second substrate layer, and an intervening insulating spacer layer. An opening in the insulating spacer layer defines a test cell which is in contact with the inner surface of the first substrate on one side and the inner surface of the second substrate on the other side. The size of the test cell is determined by the area of substrate exposed and the thickness of the spacer layer. Working and counter electrodes appropriate for the analyte to be detected are disposed on the first insulating substrate in a location within the test cell. The working and counter electrodes are associated with conductive leads that allow connection of the electrodes to a meter for dertermination of analyte. The second substrate is conductive at least in a region facing the working and counter electrodes. No functional connection of this conductive surface of the second substrate to the meter is required. When a potential difference is applied between the working and counter electrodes, because of the presence of the conductive surface on the second substrate, the relevant diffusion length is not dependent on the distance between working and counter electrodes, but is instead dependent on the distance between the first and second substrates (i.e., on the thickness of the spacer layer). This means that shorter measurement times can be achieved without having to reduce the spacing of the working and counter electrodes.

Abstract translation: 电化学测试条由第一绝缘衬底层，第二衬底层和中间绝缘间隔层形成。 绝缘间隔层中的开口限定了与第一基板的内表面和另一侧的第二基板的内表面接触的测试单元。 测试电池的尺寸由衬底暴露的面积和间隔层的厚度决定。 适于待检测分析物的工作和对电极在测试电池内的一个位置设置在第一绝缘衬底上。 工作电极和对电极与导电引线相关联，导电引线允许将电极连接到用于测定分析物的仪表。 至少在面向工作电极和对电极的区域中，第二衬底是导电的。 不需要将第二基板的该导电表面与仪表的功能连接。 当在工作电极和对电极之间施加电位差时，由于在第二衬底上存在导电表面，相关的扩散长度不依赖于工作电极和对电极之间的距离，而是取决于 第一和第二基板（即，在间隔层的厚度上）。 这意味着可以实现更短的测量时间，而不必减小工作电极和对电极的间隔。

公开(公告)号：WO2007116336A9

公开(公告)日：2008-11-27

申请号：PCT/IB2007051129

申请日：2007-03-29

Applicant: AGAMATRIX INC ,  HARDING IAN ,  IYENGAR SRIDHAR G ,  NGUYEN HA ,  WILLIAMS RICHARD

Inventor： HARDING IAN ,  IYENGAR SRIDHAR G ,  NGUYEN HA ,  WILLIAMS RICHARD

IPC: G01N33/49

CPC classification number: G01N27/26 ,  G01N33/4905 ,  G01N33/86

Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.

Abstract translation: 用于测量凝血时间的装置由第一基底形成; 第二基板; 间隔层，其设置在所述第一和第二基板之间，所述间隔层具有形成在其中的开口，所述隔离件限定了样品接收室，通气的宿室和形成用于液体在样品接收室和宿室之间移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在所述第二基板上的第二电极，所述第二电极通过所述间隔层中的第二开口暴露在所述储存部分中。 本发明的装置与连接到第一和第二电极的装置结合使用，用于测量第一和第二电极之间的电流。 观察到的电流的变化表示通过该装置的流动，并且停止流动表示凝结。

公开(公告)号：WO2008049075A2

公开(公告)日：2008-04-24

申请号：PCT/US2007081831

申请日：2007-10-18

Applicant: AGAMATRIX INC ,  DIAMOND STEVEN ,  HARDING IAN ,  IYENGAR SRIDHAR ,  WILLIAMS RICHARD

Inventor： DIAMOND STEVEN ,  HARDING IAN ,  IYENGAR SRIDHAR ,  WILLIAMS RICHARD

IPC: G01N33/48 ,  G01N33/49 ,  G01N35/00

CPC classification number: G01N27/3274

Abstract: Determination of an analyte with increased accuracy is achieved by electrochemically determining an initial analyte concentration, performing a plurality of amperometric/ potentiometric switching cycles, observing a characteristic of the signal during each of the plurality of switching cycles, determining an averaged value for the characteristic of the signal, and correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal. The characteristic of the signal that is observed is not per se indicative of the amount of analyte present in a sample. Rather, it is a characteristic of the signal that reflects the quality of the electrodes, the extent of fill of the electrochemical cell or characteristics of the sample other than analyte concentration such as oxygen levels or hematocrit.

Abstract translation: 通过电化学测定初始分析物浓度，执行多个电流/电位开关周期，观察多个开关周期中的每一个期间的信号特性，确定分析物的特性的平均值， 信号，并且校正初始测量值以获得分析物浓度的最终测量值或者根据信号的特性的平均值来拒绝初始测量值。 观察到的信号的特征本身并不表示样品中存在的分析物的量。 而是反映电极的质量，电化学电池的填充程度或样品的特性，而不是分析物浓度如氧水平或血细胞比容的信号的特征。

公开(公告)号：WO2006109277A2

公开(公告)日：2006-10-19

申请号：PCT/IB2006/051180

申请日：2006-04-15

Applicant: AGAMATRIX, INC. ,  HARDING, Ian ,  DIAMOND, Steven ,  WILLIAMS, Richard ,  IYENGAR, Sridhar

Inventor： HARDING, Ian ,  DIAMOND, Steven ,  WILLIAMS, Richard ,  IYENGAR, Sridhar

CPC classification number: G01N27/327

Abstract: Partial fill of an electrochemical test strip is determined by making a DC determination of double layer capacitance from charging or discharging charge on a test strip containing sample, for example a blood sample to be tested for glucose. The measured double layer capacitance is compared to a reference value. The double layer capacitance may be determined as an integral or differential capacitance. Double layer capacitance may also be used for quality control to monitor the quality of electrode formation, particularly in strips using screen printed electrodes.

Abstract translation: 电化学测试条的部分填充通过在含有样品的测试条（例如要测试葡萄糖的血液样品）上进行充电或放电电荷的双层电容的DC测定来确定。 将测量的双层电容与参考值进行比较。 双层电容可以被确定为积分或差分电容。 双层电容也可用于质量控制，以监测电极形成的质量，特别是使用丝网印刷电极的条带。

公开(公告)号：WO2006109275A2

公开(公告)日：2006-10-19

申请号：PCT/IB2006/051178

申请日：2006-04-15

Applicant: AGAMATRIX, INC. ,  HARDING, Ian ,  IYENGAR, Sridhar ,  WEI, Baoguo ,  DIAMOND, Steven ,  FOREST, Martin

Inventor： HARDING, Ian ,  IYENGAR, Sridhar ,  WEI, Baoguo ,  DIAMOND, Steven ,  FOREST, Martin

CPC classification number: G01N27/3272 ,  B01L3/5023 ,  B01L3/545 ,  B01L2300/02

Abstract: A test strip and analytical apparatus have pin connections permitting the definition of geographic regions or of particular customers. A test strip made for use in a particular region or for a particular customer will have pin connections matching features of the apparatus made for use in that region or by that customer. Insertion of the strip into the apparatus does not merely turn on the apparatus, but provides the regional or the customer coding. Analog switches within the apparatus allow coding of a larger number of distinct regions or customers than would otherwise be possible, all without degrading the quality of the measurements made of the fluid being tested. Conductive paths in the strips permit testing the strips during manufacture so as to detect quality lapses regarding the printing of deposition of the paths.

Abstract translation: 测试条和分析仪器具有允许定义地理区域或特定客户的引脚连接。 在特定地区或特定客户使用的测试条将具有匹配在该区域或由该客户使用的设备的特征的针脚连接。 将带插入设备不仅仅是打开设备，而是提供区域或客户编码。 装置内的模拟开关允许编码比否则可能的更多数量的不同区域或客户，而不会降低由待测流体测量的质量。 条中的导电路径允许在制造期间测试条，以便检测关于路径沉积的印刷的质量失效。

公开(公告)号：WO2020072432A1

公开(公告)日：2020-04-09

申请号：PCT/US2019/053977

申请日：2019-10-01

Applicant: ELEMENTAL MACHINES, INC. ,  IYENGAR, Sridhar ,  HARDING, Ian

Inventor： IYENGAR, Sridhar ,  HARDING, Ian

IPC: G06Q10/04

Abstract: A method for determining whether a given run of a process having a defined protocol is on a trajectory for successful completion is provided. The method includes the step of initiating a run of the defined protocol of the process. During the initiated run, obtaining information reflecting variables that may affect the quality of the process. A preferred trajectory model for achieving a successful implementation of a process is also obtained. The information reflecting the variables that affect the quality of the process are compared with the preferred trajectory model. This comparison allows a determination of offset of the value of the determined variables to the value of the same variables of the preferred trajectory model. The magnitude or amount of offset is indicative of the whether the run initiated in step is on a path or trajectory for success.