公开(公告)号：WO2014099669A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/075059

申请日：2014-01-15

申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. ,  IYER, Arun V. ,  JORDAN, Dianna M. Murphy ,  PATTERSON, Abby Rae ,  ROOF, Michael B. ,  VAUGHN, Eric Martin ,  VICTORIA, Joseph Gilbert ,  VISEK, Callie Ann

发明人： IYER, Arun V. ,  JORDAN, Dianna M. Murphy ,  PATTERSON, Abby Rae ,  ROOF, Michael B. ,  VAUGHN, Eric Martin ,  VICTORIA, Joseph Gilbert ,  VISEK, Callie Ann

IPC分类号： C07K14/015 ,  A61K39/23 ,  C12N7/00 ,  C07K16/08 ,  G01N33/569

CPC分类号： A61K39/23 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14021 ,  C12N2750/14022 ,  C12N2750/14034 ,  G01N33/6893

摘要： The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5A (PPV5A) that infects, inter alia , domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.

摘要翻译： 本发明提供新颖的核苷酸序列，蛋白质序列，免疫原性组合物，疫苗以及涉及制造和使用感染尤其是家猪的新型猪细小病毒5A（PPV5A）的方法。 组合物和方法提供了用于检测所述新病毒的感染，监测野生和家畜和牛群中的病毒序列的遗传变化，以及制备和使用新型疫苗以保护动物免受病毒感染。

公开(公告)号：WO2014127084A1

公开(公告)日：2014-08-21

申请号：PCT/US2014/016165

申请日：2014-02-13

申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. ,  IYER, Arun V. ,  JORDAN, Dianna M. Murphy ,  PATTERSON, Abby Rae ,  ROOF, Michael B. ,  VAUGHN, Eric Martin ,  VICTORIA, Joseph Gilbert ,  VISEK, Callie Ann

发明人： IYER, Arun V. ,  JORDAN, Dianna M. Murphy ,  PATTERSON, Abby Rae ,  ROOF, Michael B. ,  VAUGHN, Eric Martin ,  VICTORIA, Joseph Gilbert ,  VISEK, Callie Ann

IPC分类号： C07K14/015 ,  C12N7/00

CPC分类号： A61K39/23 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14321 ,  C12N2750/14322 ,  C12N2750/14334 ,  G01N33/56983 ,  G01N2333/015 ,  G01N2469/10

摘要： The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5B (PPV5B) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.

摘要翻译： 本发明提供新颖的核苷酸序列，蛋白质序列，免疫原性组合物，疫苗和涉及制造和使用感染尤其是家猪的新型猪细小病毒5B（PPV5B）的方法。 组合物和方法提供了用于检测所述新病毒的感染，监测野生和家畜和牛群中的病毒序列的遗传变化，以及制备和使用新型疫苗以保护动物免受病毒感染。

公开(公告)号：WO2014105672A1

公开(公告)日：2014-07-03

申请号：PCT/US2013/076807

申请日：2013-12-20

申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH ,  JORDAN, Dianna M. Murphy ,  MARTINSON, Brian Thomas ,  MUEHLENTHALER, Christine Margaret ,  NEUBAUER, Axel ,  IYER, Arun V.

发明人： JORDAN, Dianna M. Murphy ,  MARTINSON, Brian Thomas ,  MUEHLENTHALER, Christine Margaret ,  NEUBAUER, Axel ,  IYER, Arun V.

IPC分类号： C12R1/35 ,  A61K39/02 ,  C12N1/20 ,  C12N5/077 ,  C12N5/071

CPC分类号： A61K39/0241 ,  A61K2039/521 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N1/20 ,  C12N1/36 ,  C12N5/0686 ,  C12N2502/70

摘要： The present invention relates to a method for the preparation of an immunogenic composition for the treatment and/or prophylaxis of mycoplasma infections in a subject comprising the cultivation of mycoplasma bacteria in a serum-reduced or swine serum-free, eukaryotic cell system; obtaining an antigen of the mycoplasma bacteria; and addition of a pharmaceutically acceptable carrier. Further, the present invention relates to the immunogenic composition obtainable by said method and a method for immunizing a subject comprising the administration of said immunogenic composition to a subject.

摘要翻译： 本发明涉及一种制备用于治疗和/或预防受试者支原体感染的免疫原性组合物的方法，包括在血清还原或猪血清的真核细胞系统中培养支原体细菌; 获得支原体细菌的抗原; 并加入药学上可接受的载体。 此外，本发明涉及可通过所述方法获得的免疫原性组合物和包括向受试者施用所述免疫原性组合物的受试者的免疫方法。

公开(公告)号：WO2014105671A1

公开(公告)日：2014-07-03

申请号：PCT/US2013/076803

申请日：2013-12-20

申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH ,  JORDAN, Dianna M. Murphy ,  MARTINSON, Brian Thomas ,  MUEHLENTHALER, Christine Margaret ,  NEUBAUER, Axel ,  IYER, Arun V.

发明人： JORDAN, Dianna M. Murphy ,  MARTINSON, Brian Thomas ,  MUEHLENTHALER, Christine Margaret ,  NEUBAUER, Axel ,  IYER, Arun V.

IPC分类号： A61K39/02 ,  A61K39/00 ,  C12R1/35 ,  C12N1/20

CPC分类号： A61K39/0241 ,  A61K35/22 ,  A61K2039/70

摘要： The present invention relates to an immunogenic composition comprising: a) one or more antigen of M. hyorhinis and one or more antigens of M. hyosynoviae; and b) a pharmaceutically acceptable carrier. Furthermore, the present invention relates to an immunogenic composition that comprises a) one or more mycoplasma antigens of mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae; and b) one or more components of a eukaryotic cell system. Moreover, the present invention also provides an immunogenic composition obtained by a method comprising a) cultivation of a mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae in a serum-reduced, eukaryotic cell system; b) obtaining an antigen of such mycoplasma bacteria; and c) addition of a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及一种免疫原性组合物，其包含：a）一种或多种羊水藓的抗原和一种或多种hy蛇科的抗原; 和b）药学上可接受的载体。 此外，本发明涉及免疫原性组合物，其包含a）一种或多种支原体细菌的支原体抗原，所述支原体抗原选自湿疣菌，猪肺炎支原体和hy蛇科; 和b）真核细胞系统的一种或多种组分。 此外，本发明还提供了一种通过以下方法获得的免疫原性组合物，所述方法包括：a）在血清还原的真核细胞系统中培养选自由猪肺炎支原体，猪肺炎支原体和猪hy属细菌组成的组的支原体细菌; b）获得这种支原体细菌的抗原; 和c）加入药学上可接受的载体。