公开(公告)号：WO2012158997A9

公开(公告)日：2013-12-05

申请号：PCT/US2012038498

申请日：2012-05-18

Applicant: 3M INNOVATIVE PROPERTIES CO ,  FOCUS DIAGNOSTICS INC ,  LUDOWISE PETER D ,  WHITMAN DAVID A ,  ARMANTROUT KYLE C ,  EXNER MAURICE ,  JACKY LUCIEN A E ,  TABB MICHELLE

Inventor： LUDOWISE PETER D ,  WHITMAN DAVID A ,  ARMANTROUT KYLE C ,  EXNER MAURICE ,  JACKY LUCIEN A E ,  TABB MICHELLE

IPC: B01L3/00

CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/6486 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0441

Abstract: Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.

Abstract translation: 用于处理样品处理装置的系统和方法。 该系统可以包括样品处理装置，该样品处理装置包括检测室，被配置为围绕旋转轴线旋转样品处理装置的马达和相对于样品处理装置可操作地定位的光学模块，并配置成确定所选择的材料体积 存在于样品处理装置的检测室中。 该方法可以包括围绕旋转轴旋转样品处理装置，并且在旋转样品处理装置的同时确定所选择的材料体积是否存在于检测室中。 在一些实施例中，确定所选择的材料体积是否存在可以通过光学询问该检测室以获得该材料的光学特性。

公开(公告)号：WO2020264051A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/039457

申请日：2020-06-24

Applicant: CHROMACODE, INC. ,  MACDONALD, Christopher ,  JACKY, Lucien ,  RAJAGOPAL, Aditya

Inventor： MACDONALD, Christopher ,  JACKY, Lucien ,  RAJAGOPAL, Aditya

IPC: C12Q1/68

Abstract: Methods for differentially quantifying nucleic acids in a biological sample using differentially methylated loci include forming a digested biological sample in a solution of a methylation- sensitive restriction enzyme to cleave an unmethylated group of nucleic acids, forming a reaction mixture, amplifying the reaction mixture to generate a first signal from the a group of detection probes and a second signal from a second group of detection probes, determining a ratio comprising a first value derived from the first signal to a second value derived from the second signal, and identifying the proportion of nucleic acid in the biological sample originating from the first plurality of nucleic acids.

公开(公告)号：WO2012158997A1

公开(公告)日：2012-11-22

申请号：PCT/US2012/038498

申请日：2012-05-18

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FOCUS DIAGNOSTICS, INC. ,  LUDOWISE, Peter D. ,  WHITMAN, David A. ,  ARMANTROUT, Kyle C. ,  EXNER, Maurice ,  JACKY, Lucien A.E. ,  TABB, Michelle

Inventor： LUDOWISE, Peter D. ,  WHITMAN, David A. ,  ARMANTROUT, Kyle C. ,  EXNER, Maurice ,  JACKY, Lucien A.E. ,  TABB, Michelle

IPC: B01L3/00

CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/6486 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0441

Abstract: Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.

Abstract translation: 用于处理样品处理装置的系统和方法。 该系统可以包括样品处理装置，该样品处理装置包括检测室，被配置为围绕旋转轴线旋转样品处理装置的马达和相对于样品处理装置可操作地定位的光学模块，并配置成确定所选择的材料体积 存在于样品处理装置的检测室中。 该方法可以包括围绕旋转轴旋转样品处理装置，并且在旋转样品处理装置的同时确定所选择的材料体积是否存在于检测室中。 在一些实施例中，确定所选择的材料体积是否存在可以通过光学询问该检测室以获得该材料的光学特性。