公开(公告)号：WO2010107930A1

公开(公告)日：2010-09-23

申请号：PCT/US2010/027682

申请日：2010-03-17

Applicant: THE UWM RESEARCH FOUNDATION, INC. ,  ZHANG, Hao, F. ,  JIAO, Shuliang

Inventor： ZHANG, Hao, F. ,  JIAO, Shuliang

IPC: A61B3/14

CPC classification number: A61B8/10 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0095 ,  A61B8/4472 ,  G01B9/0203 ,  G01B9/02044 ,  G01B9/02091 ,  G01N29/0681 ,  G01N29/2418

Abstract: Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser ophthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

Abstract translation: 本发明的各种实施例包括基于光声和激光光学扫描显微镜的多模式功能成像的系统和方法。 具体地，本发明的至少一个实施例利用隐形眼镜与超声换能器的组合来获取光声显微镜数据。 传统的发散成像方式如共聚焦扫描激光眼底镜检查和光声显微镜在单个激光系统内组合。 生物样品的功能成像可用于各种医学和生物目的。

公开(公告)号：WO2012174413A1

公开(公告)日：2012-12-20

申请号：PCT/US2012/042724

申请日：2012-06-15

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  NORTHWESTERN UNIVERSITY ,  JIAO, Shuliang ,  ZHANG, Hao

Inventor： JIAO, Shuliang ,  ZHANG, Hao

IPC: A61B3/00

CPC classification number: G01B9/0203 ,  G01B9/02091 ,  G01N29/0681 ,  G01N29/2418

Abstract: A system and method for providing an optical coherence photoacoustic (OC-PAM) microscopy. An OC-PAM microscope includes a light source that outputs light, a scanner, a detector, a transducer, and an image processing module. The scanner receives the light and scans the light across a sample. The detector receives reflected light from the sample in response to the scanned light. The transducer detects photoacoustic waves induced in the sample by the scanned light. The image processing module receives output from the detector and the transducer and generates a photoacoustic microscopy (PAM) image and an optical coherence tomography (OCT) image based on the received output from the detector and the transducer. The PAM and OCT image data may be fused to form a single, OC-PAM image. Additionally, a series of PAM images and OCT images, respectively, may be combined to generate three-dimensional PAM and OCT images, respectively.

Abstract translation: 一种用于提供光学相干光声（OC-PAM）显微镜的系统和方法。 OC-PAM显微镜包括输出光的光源，扫描仪，检测器，换能器和图像处理模块。 扫描仪接收光并扫描样品上的光。 检测器响应于扫描光接收来自样品的反射光。 传感器通过扫描光检测样品中感应的光声。 图像处理模块接收来自检测器和换能器的输出，并且基于从检测器和换能器接收的输出产生光声显微镜（PAM）图像和光学相干断层摄影（OCT）图像。 PAM和OCT图像数据可以被融合以形成单个OC-PAM图像。 另外，可分别组合一系列PAM图像和OCT图像以分别产生三维PAM和OCT图像。

公开(公告)号：WO2010065694A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066501

申请日：2009-12-03

Applicant: UNIVERSITY OF MIAMI ,  JIAO, Shuliang ,  HUANG, Xiangrun ,  KNIGHTON, Robert

Inventor： JIAO, Shuliang ,  HUANG, Xiangrun ,  KNIGHTON, Robert

IPC: A61B3/00

CPC classification number: A61B3/102

Abstract: A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes in relative reflectance values indicate damage to the retinal nerve fibers and indicate early glaucomatous optical neuropathy.

Abstract translation: 用于分析和检测与青光眼相关的视网膜早期损伤的系统。 比较不同波长的光的视网膜神经纤维层的反射率。 相对反射率值的变化表示损伤视网膜神经纤维，并指示早期青光眼性光学神经病变。

公开(公告)号：WO2006058735A1

公开(公告)日：2006-06-08

申请号：PCT/EP2005/012801

申请日：2005-12-01

Applicant: CARL ZEISS MEDITEC AG ,  UNIVERSITY OF MIAMI ,  KNIGHTON, Robert, W. ,  JIAO, Shuliang ,  GREGORI, Giovanni ,  PULIAFITO, Carmen, A.

Inventor： KNIGHTON, Robert, W. ,  JIAO, Shuliang ,  GREGORI, Giovanni ,  PULIAFITO, Carmen, A.

IPC: A61B3/12 ,  G01B9/02

CPC classification number: G01B9/02044 ,  A61B3/102 ,  G01B9/02089 ,  G01B9/02091

Abstract: A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for retreatment.

Abstract translation: 一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。 在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。 作为示例，扫描可以包括光谱域扫描。 可以实时获取眼底强度图像。 可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。 可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而无需首先需要3-D数据集的全部分割。 有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。 这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的液体的返回。

公开(公告)号：WO2010065694A3

公开(公告)日：2010-10-28

申请号：PCT/US2009066501

申请日：2009-12-03

Applicant: UNIV MIAMI ,  JIAO SHULIANG ,  HUANG XIANGRUN ,  KNIGHTON ROBERT

Inventor： JIAO SHULIANG ,  HUANG XIANGRUN ,  KNIGHTON ROBERT

IPC: A61B3/00

CPC classification number: A61B3/102 ,  A61B3/1241

Abstract: A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes in relative reflectance values indicate damage to the retinal nerve fibers and indicate early glaucomatous optical neuropathy.

Abstract translation: 用于分析和检测与青光眼相关的视网膜早期损伤的系统。 比较了视网膜神经纤维层对不同波长的光的反射率。 相对反射率值的变化表明对视网膜神经纤维的损伤并指示早期青光眼性视神经病变。

公开(公告)号：WO2010107933A1

公开(公告)日：2010-09-23

申请号：PCT/US2010/027685

申请日：2010-03-17

Applicant: THE UWM RESEARCH FOUNDATION, INC. ,  ZHANG, Hao, F. ,  JIAO, Shuliang

Inventor： ZHANG, Hao, F. ,  JIAO, Shuliang

IPC: A61B8/00

CPC classification number: A61B8/10 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0095 ,  A61B8/4472 ,  G01B9/0203 ,  G01B9/02044 ,  G01B9/02091 ,  G01N29/0681 ,  G01N29/2418

Abstract: Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser ophthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

Abstract translation: 本发明的各种实施例包括基于光声和激光光学扫描显微镜的多模式功能成像的系统和方法。 具体地，本发明的至少一个实施例利用隐形眼镜与超声换能器的组合来获取光声显微镜数据。 传统的发散成像方式如共聚焦扫描激光眼底镜检查和光声显微镜在单个激光系统中组合。 生物样品的功能成像可用于各种医学和生物目的。

公开(公告)号：WO2009061756A1

公开(公告)日：2009-05-14

申请号：PCT/US2008/082393

申请日：2008-11-05

Applicant: UNIVERSITY OF MIAMI ,  JIAO, Shuliang ,  WANG, Jianhua

Inventor： JIAO, Shuliang ,  WANG, Jianhua

IPC: A61B6/00

CPC classification number: A61B5/0059 ,  A61B3/102 ,  A61B3/1173 ,  A61B5/0066

Abstract: The present invention advantageously provides a method and system for increasing imaging depth. In particular, the present invention provides an OCT system that includes two or more linked OCT engines operating at different wavelengths to image different depths at different focal planes. The multiple independent images are then combined, to effectively extend the operating depth of an OCT system and thereby provide enhanced eye accommodation research capabilities, as well as the capability to enhance or otherwise extend the imaging depth for other tissue of interest.

Abstract translation: 本发明有利地提供了一种用于增加成像深度的方法和系统。 特别地，本发明提供一种OCT系统，其包括以不同波长工作的两个或更多个连接的OCT引擎，以在不同焦平面上成像不同的深度。 然后组合多个独立图像，以有效地延长OCT系统的操作深度，从而提供增强的眼睛适应性研究能力，以及增强或以其他方式延伸其他感兴趣组织的成像深度的能力。

公开(公告)号：WO2009058850A1

公开(公告)日：2009-05-07

申请号：PCT/US2008/081568

申请日：2008-10-29

Applicant: UNIVERSITY OF MIAMI ,  WANG, Jianhua ,  JIAO, Shuliang

Inventor： WANG, Jianhua ,  JIAO, Shuliang

IPC: A61B5/16 ,  A61B8/06

CPC classification number: A61B3/101 ,  A61B3/102 ,  A61B5/0059 ,  A61B5/0066

Abstract: A method and system for imaging tear film on an ocular surface. The method and system includes depositing a contrasting agent onto the ocular surface. The method may further include positioning an ocular device about the ocular surface. An OCT scanner may then image the ocular surface to detect impairments in the boundary layer between the tear film and the ocular device or the boundary between the tear meniscus and the ocular device.

Abstract translation: 一种用于在眼表上成像泪膜的方法和系统。 该方法和系统包括将对比剂沉积在眼表面上。 该方法还可以包括围绕眼表面定位眼睛装置。 然后，OCT扫描仪可以对眼表进行成像，以检测泪液膜和眼部装置之间的边界层中的损伤或泪液弯液面与眼睛装置之间的边界。