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公开(公告)号：WO2016154201A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023579
申请日：2016-03-22
Applicant: ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： SHI, Songtao
CPC classification number: A61K38/2006 , A61K35/28 , C07K14/545 , C12N5/0632 , C12N5/0668 , C12N2501/2301
Abstract: This disclosure relates to a stem cell treatment. This disclosure also relates to an IL-1RA treatment. This disclosure also relates to a composition comprising stem cells and preparation of this composition. This disclosure also relates to a composition comprising IL-1RA, an IL-1RA substitute, or a combination thereof. This disclosure also relates to preparation of this composition. This disclosure further relates to a wound treatment using a composition comprising IL-1RA, an IL-1RA substitute, or a combination thereof. This disclosure also further relates to a treatment to reduce scar formation by using a composition comprising IL-1RA, an IL-1RA substitute, or a combination thereof.
Abstract translation: 本公开涉及干细胞治疗。 本公开还涉及IL-1RA治疗。 本公开还涉及包含干细胞的组合物和该组合物的制备。 本公开还涉及包含IL-1RA，IL-1RA替代物或其组合的组合物。 本公开还涉及该组合物的制备。 本公开还涉及使用包含IL-1RA，IL-1RA替代物或其组合的组合物的伤口治疗。 本公开还涉及通过使用包含IL-1RA，IL-1RA替代物或其组合的组合物来减少瘢痕形成的治疗。
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2.发明申请
公开(公告)号：WO2023069236A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/045003
申请日：2022-09-28
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： GOEPPERT, Alain , KOCH, Christopher J. , PRAKASH, G.K. Surya , SEN, Raktim
IPC: C10L3/08 , C07C29/132 , C10L3/06
Abstract: A liquid phase process for direct utilization of inorganic metal carbonate and related salts under hydrogenative conditions to produce value-added fuels and feedstocks such as methanol, methane, carbon monoxide, and higher hydrocarbons. Advantageously, the reaction can use heterogeneous catalysts. The hydrogenation proceeds with high selectivity and yield for the desired product at relatively low temperatures, along with co-production of metal hydroxide. The metal hydroxide can be used to capture CO2, forming metal carbonates and bicarbonates that can be reused to produce more methanol and methane, hydrocarbons and carbon monoxide, closing the loop. Such a hydrogenation process can thus also be used in a "carbon capture and recycling" manner to produce renewable methane, methanol, carbon monoxide, hydrocarbons, and other carbon feedstocks from CO2 sourced from any natural and anthropogenic emissions as well as from ambient air.
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公开(公告)号：WO2023022783A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/033608
申请日：2022-06-15
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： XIE, Wenjun , WARSHEL, Arieh
Abstract: A method for producing enzyme mutants includes a generative model parameterized using homologous sequences of wild-type enzymes. Based on a distance between a mutated amino acid residue of each mutant and a corresponding substrate when the substrate is bound to the mutant being less than or equal to a first threshold, the processor may select a first candidate set of enzyme mutants and calculate a statistical energy of each mutant of the first candidate set, and identify, based on the calculated statistical energies, a first set of enzyme mutants among the first candidate set to improve enzyme efficiency. Based on the distance being larger than or equal to a second threshold, the processor may select a second candidate set of enzyme mutants and calculate a statistical energy of each mutant of the second candidate set, and identify, based on the calculated statistical energies, a second set of enzyme mutants among the second candidate set of enzyme mutants to improve protein stability.
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公开(公告)号：WO2022256694A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/032223
申请日：2022-06-03
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： COHEN, Pinchas , MILLER, Brendan , KIM, Su-Jeong
Abstract: Described herein is a novel, mitochondrial encoded, open reading frame that leads to the production of a new mitochondrial peptide called SHMOOSE. SHMOOSE is a 58-amino-acid peptide and, within its open reading frame, contains a genome-wide significant small nucleotide polymorphism (SNP) that markedly increased risk for Alzheimer's disease, brain structure, brain gene expression, and cognition. SHMOOSE increased neuronal-type cell survival and protected against amyloid beta toxicity. Metabolomic studies revealed a role for the peptide in energy optimization, whose dysfunction and dysregulation leads to cell death in physiologically notable regions of the brain in neurodegenerative diseases such as Alzheimer's and Parkinson's. Methods and compositions, including peptide analogues and derivatives, are described for treatment and diagnostics.
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公开(公告)号：WO2022241308A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/029421
申请日：2022-05-16
Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： FERRARA, Katherine, W , WODNICKI, Robert, Gideon , FOIRET, Josquin, L , PARK, Eunyeong , PODKOWA, Anthony, S , BENDJADOR, Hanna , WONSEOK, Choi
IPC: G01S15/89
Abstract: Ultrasound (US ) imaging is scaled to arrays having a large number of elements. We use "active windows" to define the parts of the overall array that are active for transmission and reception. Each active window is 2D. Local electronics can move these active windows freely within the array, either together or independently. This effectively provides fast scanning by electronically moving the active windows around within a large stationary array. All of the elements within an active window are individually controlled for beam forming, focusing etc. by beam forming electronics in the system controller. Thus there is no need to have all of the elements of the large, stationary 2D ultrasound array connected to the system controller.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2022232055A1
公开(公告)日：2022-11-03
申请号：PCT/US2022/026190
申请日：2022-04-25
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： CHEN, Shuo-Wei , RASUL, Rezwan
Abstract: A compute in-memory architecture comprising multiple neurons is provided. Each neuron includes one or more storage compute cells, each of which includes a logic circuit configured to receive a multi-bit input and a weight. The weight is defined by one or more weight bits. The logic circuit is further configured to output a control voltage corresponding to logic 'HIGH' when XNOR operation between an input sign bit and a corresponding weight bit is 1 and a corresponding input magnitude bit is also 1. A first digital-to-analog converter is formed from a first MOSCAP group in electrical communication with the logic circuit. The first MOSCAP group includes a total number of MOSCAPs equal to input magnitude bit resolution times weight bit resolution. Characteristically, each MOSCAP in the first MOSCAP group has a first end that receives the control voltage, and a second end in electrical communication with a first summation line.
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公开(公告)号：WO2022183009A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/017934
申请日：2022-02-25
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： LIEW, Sook-Lei , MARIN-PARDO, Octavio , PHANORD, Coralie
Abstract: A plurality of sensors detect neural activity and/or muscle activity of a person. A display renders an image with an avatar that represents the person. A processor moves a portion of the avatar in response to calculations performed on signals corresponding to the neural activity and the muscle activity. The avatar may be caused to move in a manner corresponding to an expected muscle movement of the person. However, due to illness or disease, the person may be unable to fully execute the expected muscle movement. By watching the avatar move in response to efforts to execute an expected muscle movement, the person may train his or her body to more fully execute desired muscle movements, such as through neurofeedback for rehabilitation.
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公开(公告)号：WO2022157674A1
公开(公告)日：2022-07-28
申请号：PCT/IB2022/050497
申请日：2022-01-21
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： ZAVALETA, Cristina , EREMINA, Olga , CZAJA, Alexander
IPC: G01N33/543 , G01N21/65 , G01N33/58
Abstract: This disclosure relates to a rapid molecular imaging strategy that utilizes Raman spectroscopy to interrogate the molecular expression of samples, for example, histology samples. This disclosure also relates to surface-enhanced Raman spectroscopy nanoparticles (SERS-NP) as contrast agents that exhibit unsurpassed multiplexing capabilities to offer exceptional specificity. This disclosure also relates to a SERS-NP comprising a Raman active metallic core, a Raman active layer, and a shell that may offer ultra-high diagnostic sensitivity (e.g., femtomolar level). This disclosure also relates to chemically modifying these new contrast agents to target a plurality of biomarkers within the sample. This disclosure also relates to rapid assessment of the molecular expression profile of the entire sample, for example, a whole tissue section, in a single image.
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公开(公告)号：WO2022155493A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012559
申请日：2022-01-14
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： MOLISCH, Andreas , MECKLENBRAEUKER, Christoph , POHL, Thomas , HAMMOUD, Hussein , ZHANG, Yuning
Abstract: A redirecting rotating mirror arrangement includes a directional antenna subcomponent having a direction of maximum received or transmitted beam intensity. The redirecting rotating mirror arrangement also includes a rotatable mirror that reflects an electromagnetic beam to or from the directional antenna subcomponent. The rotatable mirror is inclined at an inclination angle with respect to a horizontal plane. The arrangement also includes a motor that rotates the rotatable mirror about the direction of maximum received or transmitted beam intensity such that the electromagnetic beam is either received from or transmitted to a range of angles as the rotatable mirror rotates.
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公开(公告)号：WO2022147507A1
公开(公告)日：2022-07-07
申请号：PCT/US2022/011049
申请日：2022-01-03
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： ANTYPAS, Robert , WANG, Joseph
Abstract: A device and method for emitting an electrospray of ionized particles is disclosed, comprising a reservoir, an emitter in communication with the reservoir and having openings, wherein the openings are configured to permit release of the liquid media therefrom in response to a dynamic magnetic field; and an element for generating a dynamic magnetic field that runs through the emitter. The element may comprise two orthogonal Helmholtz coil pairs. In another example embodiment, an electrospray thruster is disclosed. The electrospray thruster may comprise: a reservoir for accommodating a volume of liquid media capable of being ionized; an emitter grid comprising a plurality of emitters, wherein each emitter of the plurality of emitters is in communication with the reservoir and comprises an opening disposed therethrough; and an element for causing the liquid media to be ionized from the emitter by a dynamic magnetic field.
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