公开(公告)号：WO2006088902A2

公开(公告)日：2006-08-24

申请号：PCT/US2006/005235

申请日：2006-02-14

Applicant: JOHNSON, Robert, E. ,  JOHNSON, Paul, R.

Inventor： JOHNSON, Paul, R.

IPC: B32B3/06

CPC classification number: B32B5/18 ,  A43B17/02 ,  A43B17/14 ,  B32B5/22 ,  B32B2250/03 ,  B32B2266/06 ,  B32B2266/08 ,  B32B2437/02

Abstract: The present invention provides individual solutions to workplace fatigue and stress by determining the specific support needed for each individual. Specifically, the present invention defines and utilizes an ergonomic interaction factor to enable selection of a proper fitting shoe. Such selection occurs in one embodiment by dividing a person's weight by the contact area of the bottom of their feet.

Abstract translation: 本发明通过确定每个人所需的具体支持，为工作场所的疲劳和压力提供单独的解决方案。 具体地说，本发明定义并利用符合人机工程学的相互作用因子，以使得能够选择合适的配合鞋。 在一个实施例中，通过将人的重量除以其脚底部的接触面积来进行这种选择。

公开(公告)号：WO1996019374A1

公开(公告)日：1996-06-27

申请号：PCT/US1995016743

申请日：1995-12-19

Applicant: JOHNSON, Robert, E. ,  JOHNSON, Deborah, K.

IPC: B62D55/075

CPC classification number: A61G5/061 ,  A61G5/066 ,  A61G5/107 ,  A61G5/1075 ,  A61G2203/14 ,  B62D55/075 ,  Y10S180/907 ,  Y10S280/10

Abstract: In order to provide safe and effective surface climbing vehicles, the vehicle includes a base (56) for supporting a platform (57) to be maintained in a generally horizontal orientation. The mechanism (98) automatically raises and lowers the platform as the vehicle is descending or climbing the surface, respectively, in order to maintain the platform in the generally horizontal orientation. With this arrangement, the vehicle further includes a pair of endless belts (1) normally to be maintained in driving engagement with the surface in a manner to conform to the surface during climbing and descending.

Abstract translation: 为了提供安全有效的表面爬坡车辆，车辆包括用于支撑平台（57）的基座（56），以保持大致水平的方向。 机构（98）分别在车辆下降或爬升时自动升高和降低平台，以便将平台保持在大致水平的方向。 通过这种布置，车辆还包括一对环形皮带（1），通常在爬升和下降过程中保持与表面的驱动接合。

公开(公告)号：WO2006079054A2

公开(公告)日：2006-07-27

申请号：PCT/US2006/002402

申请日：2006-01-24

Applicant: JOHNSON TECHNOLOGIES CORPORATION ,  JOHNSON, Paul, R. ,  JOHNSON, Robert, E.

Inventor： JOHNSON, Paul, R. ,  JOHNSON, Robert, E.

IPC: B32B3/06

CPC classification number: B32B7/02 ,  A47G27/0231 ,  B32B3/06 ,  B32B3/263 ,  B32B27/065 ,  B32B27/30 ,  B32B2266/0235 ,  B32B2266/0278 ,  B32B2307/102 ,  B32B2419/04 ,  B32B2471/04 ,  Y10T428/169 ,  Y10T428/24 ,  Y10T428/24008 ,  Y10T428/24017 ,  Y10T428/24025

Abstract: A matting construction includes a multilayer thickness for supporting at least a user thereon, the multilayer thickness may have an outer layer which enables a user to ambulate without slipping thereon; a compressible layer for absorbing at least a portion of the weight of the user, and a peripheral frame member disposed between the outer layer and the compressible layer. The peripheral frame member may be disposed at an angle from the horizontal and the frame member is fixedly attached between the outer layer and the compressible layer.

Abstract translation: 消光结构包括用于在其上至少支撑使用者的多层厚度，多层厚度可以具有使得使用者能够在没有滑动的情况下行走的外层; 用于吸收使用者的重量的至少一部分的可压缩层，以及设置在外层和可压缩层之间的外围框架构件。 外围框架构件可以与水平面成一定角度设置，并且框架构件固定地附接在外层和可压缩层之间。

公开(公告)号：WO2004019861A2

公开(公告)日：2004-03-11

申请号：PCT/US2003/024414

申请日：2003-08-05

Applicant: PHARMACIA CORPORATION ,  JOHNSON, Robert, E. ,  QI, Hong ,  BORGMEYER, Jeffry, R. ,  KESSLER, Robert, Kendall ,  ZENG, David, L.

Inventor： JOHNSON, Robert, E. ,  QI, Hong ,  BORGMEYER, Jeffry, R. ,  KESSLER, Robert, Kendall ,  ZENG, David, L.

IPC: A61K

CPC classification number: C07K16/241 ,  A61K39/39591 ,  C07K2317/24

Abstract: The present invention is directed to stable formulations of modified antibodies, each comprising an antibody fragment in an aqueous solution covalently attached to at least one nonproteinaceous polymer, such as @>lC(ethyleneglycol), through 0 succinimide moiety. CDP870 is an example of one such modified antibody. The formulations of the present invention include 0 buffer that maintains the solution at 0 pH of 3.5 to about 6, wherein all components of the modified antibody, including 0 succinimide ring of the succinimide moiety, are stable.

Abstract translation: 本发明涉及修饰抗体的稳定制剂，其各自包含在共价连接至至少一种非蛋白性聚合物如@> 1C（乙二醇）至0琥珀酰亚胺部分的水溶液中的抗体片段。 CDP870是一种这样的修饰抗体的实例。 本发明的制剂包括将溶液保持在pH为3.5至约6的溶液的0缓冲液，其中修饰的抗体包括琥珀酰亚胺部分的琥珀酰亚胺环的所有组分都是稳定的。

公开(公告)号：WO2004019860A2

公开(公告)日：2004-03-11

申请号：PCT/US2003/024413

申请日：2003-08-05

Applicant: PHARMACIA CORPORATION ,  LEWIS, Lavinia, M. ,  QI, Hong ,  JOHNSON, Robert, E.

Inventor： LEWIS, Lavinia, M. ,  QI, Hong ,  JOHNSON, Robert, E.

IPC: A61K

CPC classification number: C07K16/1289 ,  A61K47/60 ,  C07K2317/55

Abstract: The present invention is directed to novel formulations of modified antibodies and to methods of producing the same. The modified antibodies formulated according to the present invention each comprise an antibody fragment covalently attached to at least one nonproteinaceous polymer, such as poly(ethyleneglycol). CDP870 is an example of one such modified antibody, a therapeutic modified antibody. One method disclosed herein involves the removal from a solution of the modified antibody of molecules capable of adversely affecting the stability or solubility of the modified antibody after lyophilization (e.g., by dialysis or diafiltration), followed by lyophilization of the modified antibody. Another method involves concentration of a modified antibody solution by equilibrium dialysis. The methods of the present invention can be used to produce formulations suitable for use in subcutaneous and parenteral injection, including high concentration formulations.

Abstract translation: 本发明涉及修饰抗体的新制剂及其制备方法。 根据本发明配制的修饰的抗体各自包含与至少一种非蛋白质聚合物如聚（乙二醇）共价连接的抗体片段。 CDP870是一种这样的修饰抗体（治疗性修饰的抗体）的实例。 本文公开的一种方法包括从修饰的抗体的溶液中除去能够不利地影响修饰的抗体在冻干（例如通过透析或渗滤）之后的稳定性或溶解度，然后冻干修饰的抗体的分子。 另一种方法涉及通过平衡透析浓缩修饰的抗体溶液。 本发明的方法可用于制备适用于皮下和肠胃外注射的制剂，包括高浓度制剂。

公开(公告)号：WO2009097581A1

公开(公告)日：2009-08-06

申请号：PCT/US2009/032734

申请日：2009-01-30

Applicant: AMERICAN INTERNATIONAL GROUP, INC. ,  SAGALOW, Ty ,  ORLOWICZ, Charles, P. ,  BURRELL, Susan, E. ,  MOONEY, Phyllis, Ann ,  JOHNSON, Robert, E. ,  SHIMOMURA, Akiko ,  FEIGHAN, Michael ,  PEDERSEN, Leah, C.

Inventor： SAGALOW, Ty ,  ORLOWICZ, Charles, P. ,  BURRELL, Susan, E. ,  MOONEY, Phyllis, Ann ,  JOHNSON, Robert, E. ,  SHIMOMURA, Akiko ,  FEIGHAN, Michael ,  PEDERSEN, Leah, C.

IPC: G06Q40/00

CPC classification number: G06Q40/08

Abstract: Aspects of the invention include a method and system to develop a product within a corporate environment comprising diverse business units that are located in geographically dispersed locations. In addition, aspects of the invention provide for a streamlined product development process such that a company can efficiently launch products to market from an idea generation stage. Further aspects of the invention include systems and methods that coordinate product development activities within and between different business units within a company. Additional aspects of the invention provide for systems and methods that improve efficiency, reduce redundancy and provide synergy of expertise between different business units to develop a product.

Abstract translation: 本发明的方面包括在公司环境中开发产品的方法和系统，其包括位于地理上分散的位置的各种业务单元。 此外，本发明的方面提供了简化的产品开发过程，使得公司可以从想法生成阶段有效地将产品推向市场。 本发明的其它方面包括协调公司内部和之间不同业务部门内的产品开发活动的系统和方法。 本发明的另外的方面提供了提高效率，减少冗余并提供不同业务单元之间的专业技术协同以开发产品的系统和方法。

公开(公告)号：WO2006088902A3

公开(公告)日：2009-04-30

申请号：PCT/US2006005235

申请日：2006-02-14

Applicant: JOHNSON ROBERT E ,  JOHNSON PAUL R

Inventor： JOHNSON PAUL R

IPC: A43B13/38 ,  A43B13/42

CPC classification number: B32B5/18 ,  A43B17/02 ,  A43B17/14 ,  B32B5/22 ,  B32B2250/03 ,  B32B2266/06 ,  B32B2266/08 ,  B32B2437/02

Abstract: The present invention provides individual solutions to workplace fatigue and stress by determining the specific support needed for each individual. Specifically, the present invention defines and utilizes an ergonomic interaction factor to enable selection of a proper fitting shoe. Such selection occurs in one embodiment by dividing a person's weight by the contact area of the bottom of their feet.

Abstract translation: 本发明通过确定每个人所需的具体支持，为工作场所的疲劳和压力提供单独的解决方案。 具体地说，本发明定义并利用符合人机工程学的相互作用因子，以使得能够选择合适的配合鞋。 在一个实施例中，通过将人的重量除以其脚底部的接触面积来进行这种选择。

公开(公告)号：WO2006079054A3

公开(公告)日：2007-11-01

申请号：PCT/US2006002402

申请日：2006-01-24

Applicant: JOHNSON TECHNOLOGIES CORP ,  JOHNSON PAUL R ,  JOHNSON ROBERT E

Inventor： JOHNSON PAUL R ,  JOHNSON ROBERT E

IPC: B32B3/06

CPC classification number: B32B7/02 ,  A47G27/0231 ,  B32B3/06 ,  B32B3/263 ,  B32B27/065 ,  B32B27/30 ,  B32B2266/0235 ,  B32B2266/0278 ,  B32B2307/102 ,  B32B2419/04 ,  B32B2471/04 ,  Y10T428/169 ,  Y10T428/24 ,  Y10T428/24008 ,  Y10T428/24017 ,  Y10T428/24025

Abstract: A matting construction includes a multilayer thickness for supporting at least a user thereon, the multilayer thickness may have an outer layer which enables a user to ambulate without slipping thereon; a compressible layer for absorbing at least a portion of the weight of the user, and a peripheral frame member disposed between the outer layer and the compressible layer. The peripheral frame member may be disposed at an angle from the horizontal and the frame member is fixedly attached between the outer layer and the compressible layer.

Abstract translation: 消光结构包括用于在其上至少支撑使用者的多层厚度，多层厚度可以具有使得使用者能够在没有滑动的情况下行走的外层; 用于吸收使用者的重量的至少一部分的可压缩层，以及设置在外层和可压缩层之间的外围框架构件。 外围框架构件可以与水平面成一定角度设置，并且框架构件固定地附接在外层和可压缩层之间。

公开(公告)号：WO2004019861A3

公开(公告)日：2004-07-22

申请号：PCT/US0324414

申请日：2003-08-05

Applicant: PHARMACIA CORP ,  JOHNSON ROBERT E ,  QI HONG ,  BORGMEYER JEFFRY R ,  KESSLER ROBERT KENDALL ,  ZENG DAVID L

Inventor： JOHNSON ROBERT E ,  QI HONG ,  BORGMEYER JEFFRY R ,  KESSLER ROBERT KENDALL ,  ZENG DAVID L

IPC: A61K39/395 ,  C07K16/24 ,  A61K47/48

CPC classification number: C07K16/241 ,  A61K39/39591 ,  C07K2317/24

Abstract: The present invention is directed to stable formulations of modified antibodies, each comprising an antibody fragment in an aqueous solution covalently attached to at least one nonproteinaceous polymer, such as @>lC(ethyleneglycol), through 0 succinimide moiety. CDP870 is an example of one such modified antibody. The formulations of the present invention include 0 buffer that maintains the solution at 0 pH of 3.5 to about 6, wherein all components of the modified antibody, including 0 succinimide ring of the succinimide moiety, are stable.

Abstract translation: 本发明涉及经修饰的抗体的稳定制剂，其各自包含水溶液中的抗体片段，所述抗体片段通过0琥珀酰亚胺部分与至少一种非蛋白质聚合物（例如≥1C（乙二醇））共价连接。 CDP870是这种修饰抗体的一个例子。 本发明的制剂包括使溶液维持在3.5至约6的pH值的缓冲液，其中修饰的抗体的所有组分（包括琥珀酰亚胺部分的0琥珀酰亚胺环）都是稳定的。

公开(公告)号：WO2004019860A3

公开(公告)日：2004-07-22

申请号：PCT/US0324413

申请日：2003-08-05

Applicant: PHARMACIA CORP ,  LEWIS LAVINIA M ,  QI HONG ,  JOHNSON ROBERT E

Inventor： LEWIS LAVINIA M ,  QI HONG ,  JOHNSON ROBERT E

IPC: A61K20060101 ,  A61K39/395 ,  A61K47/48 ,  C07K16/00 ,  C07K16/12 ,  C12P21/08

CPC classification number: C07K16/1289 ,  A61K47/60 ,  C07K2317/55

Abstract: The present invention is directed to novel formulations of modified antibodies and to methods of producing the same. The modified antibodies formulated according to the present invention each comprise an antibody fragment covalently attached to at least one nonproteinaceous polymer, such as poly(ethyleneglycol). CDP870 is an example of one such modified antibody, a therapeutic modified antibody. One method disclosed herein involves the removal from a solution of the modified antibody of molecules capable of adversely affecting the stability or solubility of the modified antibody after lyophilization (e.g., by dialysis or diafiltration), followed by lyophilization of the modified antibody. Another method involves concentration of a modified antibody solution by equilibrium dialysis. The methods of the present invention can be used to produce formulations suitable for use in subcutaneous and parenteral injection, including high concentration formulations.

Abstract translation: 本发明涉及修饰抗体的新型制剂及其制备方法。 根据本发明配制的经修饰的抗体各自包含与至少一种非蛋白质聚合物如聚（乙二醇）共价连接的抗体片段。 CDP870是一种这样的修饰抗体，治疗性修饰抗体的实例。 本文公开的一种方法涉及从冻干（例如通过透析或渗滤）后可以不利地影响修饰抗体的稳定性或溶解度的分子的修饰抗体的溶液中除去，然后冻干该修饰的抗体。 另一种方法包括通过平衡透析浓缩修饰的抗体溶液。 本发明的方法可用于制备适用于皮下和肠胃外注射的制剂，包括高浓度制剂。