公开(公告)号：WO2007099289A1

公开(公告)日：2007-09-07

申请号：PCT/GB2007/000526

申请日：2007-02-14

Applicant: MEDICAL RESEARCH COUNCIL ,  JONES, William, Alexander ,  BHAKOO, Kishore, Kumar

Inventor： JONES, William, Alexander ,  BHAKOO, Kishore, Kumar

IPC: G01N33/543

CPC classification number: G01N33/54353 ,  A61K41/00 ,  A61K41/0052 ,  A61K47/6923 ,  A61K49/1875 ,  B82Y5/00

Abstract: Iron oxide nanoparticles comprising functional groups of the formula-X-NH 2 on the outer surface of said nanoparticles, wherein X is selected from O, NR, NH or S, where R is C 1-7 alkyl and conjugate particles comprising an iron oxide nanoparticle linked via a bond of formula-C=N-X-to a cell targeting ligand, where X is selected from O, NR, NH or S, where R is C 1-7 alkyl.

Abstract translation: 在所述纳米颗粒的外表面上包含式-X-NH 2官能团的氧化铁纳米颗粒，其中X选自O，NR，NH或S，其中R是C 1 包含通过式-C = NX的键连接的氧化铁纳米颗粒的偶联颗粒与细胞靶向配体结合，其中X选自O，NR，NH或S，其中R为C < 烷基。