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    METHODS FOR TRANSFERRING GENE INTO CHROMOSOME
    2.
    发明申请
    METHODS FOR TRANSFERRING GENE INTO CHROMOSOME 审中-公开
    将基因转染到染色体中的方法

    公开(公告)号：WO1997049820A1

    公开(公告)日：1997-12-31

    申请号：PCT/JP1997002187

    申请日：1997-06-25

    Applicant: KABUSHIKI KAISHA YAKULT HONSHA ,  KADOTA, Mariko ,  KIWAKI, Mayumi ,  SAWAKI, Saeko ,  SHIRASAWA, Yukio ,  SONE, Harue ,  SAKO, Tomoyuki

    Inventor： KABUSHIKI KAISHA YAKULT HONSHA

    IPC: C12N15/74

    CPC classification number: C12N15/907 ,  C12N15/746 ,  C12N15/90

    Abstract: Methods for transferring a foreign gene into a chromosome in order to eliminate unnecessary genes originating in a vector, etc. other than the foreign gene by contriving procedures for transferring the foreign gene into the vector with the use of a lysogenic phage. One of these methods comprises: the first step of acquiring a vector wherein the integration site (the attP site) of the lysogenic phage is located between a first partial sequence of the foreign gene to be transferred but lacking one terminal region and a second partial sequence of the gene lacking another terminal region and having a region overlapping that of the first partial sequence; the second step of integrating the vector obtained in the first step onto the host chromosome; and the third step of screening from among the recombinants obtained in the second step a recombinant from which the unnecessary genes originating in the vector have been eliminated owing to the homologous recombination mechanism of the overlapping region in the first and second partial sequences.

    Abstract translation: 通过设计使用溶源性噬菌体将外源基因转移到载体中的方法，将外源基因转移到染色体中以除去源自异源基因以外的载体等的不必要的基因。 这些方法之一包括：获得载体的第一步骤，其中溶源性噬菌体的整合位点（attP位点）位于待转移的外源基因的第一部分序列之间但缺少一个末端区域和第二部分序列 的缺失另一个末端区并具有与第一部分序列重叠的区域的基因; 将在第一步骤中获得的载体整合到宿主染色体上的第二步骤; 以及由第二和第二部分序列中的重叠区域的同源重组机制，在第二步中得到的重组体中筛选的第三步骤是源自载体的不必要的基因已被消除的重组体。

    TAXANE DERIVATIVES AND DRUGS CONTAINING THE SAME
    3.
    发明申请
    TAXANE DERIVATIVES AND DRUGS CONTAINING THE SAME 审中-公开
    TAXANE衍生物和含有其的药物

    公开(公告)号：WO1998002426A1

    公开(公告)日：1998-01-22

    申请号：PCT/JP1997002431

    申请日：1997-07-14

    Applicant: KABUSHIKI KAISHA YAKULT HONSHA ,  SHIMIZU, Hideaki ,  ABE, Atsuhiro ,  YAEGASHI, Takashi ,  SAWADA, Seigo ,  NAGATA, Hiroshi

    Inventor： KABUSHIKI KAISHA YAKULT HONSHA

    IPC: C07D305/14

    CPC classification number: C07D405/12 ,  C07D305/14 ,  C07D413/12 ,  C07D413/14

    Abstract: Taxane derivatives of general formula (1) and drugs containing the same wherein at least either of X and Y is -CO-A-B (wherein A is a single bond, alkylenecarbonyl or the like, and B is optionally substituted piperidono or the like); and the other thereof is t-butoxycarbonyl or the like; and Z is H or triethylsilyl. These compounds exhibit a high solubility in water and are excellent in antitumor activity.

    Abstract translation: 通式（1）的紫杉烷衍生物和含有其的药物，其中X和Y中的至少一个是-CO-A-B（其中A是单键，亚烷基羰基等，B是任选取代的哌啶子基等）; 另一方面是叔丁氧基羰基等; Z为H或三乙基甲硅烷基。 这些化合物在水中表现出高溶解性，抗肿瘤活性优异。

    PROCESS FOR PRODUCING PHOSPHATIDYLSERINES HAVING POLYBASIC UNSATURATED FATTY ACID AS SIDE CHAIN
    5.
    发明申请
    PROCESS FOR PRODUCING PHOSPHATIDYLSERINES HAVING POLYBASIC UNSATURATED FATTY ACID AS SIDE CHAIN 审中-公开
    生产具有多链脂肪酸作为侧链的磷脂酰胆碱的方法

    公开(公告)号：WO1997017460A1

    公开(公告)日：1997-05-15

    申请号：PCT/JP1996003237

    申请日：1996-11-06

    Applicant: KABUSHIKI KAISHA YAKULT HONSHA ,  SAKAI, Masashi ,  YAMATOYA, Hideyuki ,  KUDO, Satoshi

    Inventor： KABUSHIKI KAISHA YAKULT HONSHA

    IPC: C12P13/00

    CPC classification number: C12P7/6481 ,  C12P7/6472 ,  C12P13/06

    Abstract: A process for producing phosphatidylserines having a side chain derived from a polybasic unsaturated fatty acid. A natural lecithin containing a fatty acid side chain derived from a polybasic unsaturated fatty acid is used as the feedstock. Phospholipase D is caused to act on the natural lecithin as a substrate in the presence of serine, whereby phosphatidylserines having a side chain derived from a polybasic unsaturated fatty acid can be easily obtained through only one reaction step.

    Abstract translation: 一种具有衍生自多元不饱和脂肪酸的侧链的磷脂酰丝氨酸的方法。 使用含有源自多元不饱和脂肪酸的脂肪酸侧链的天然卵磷脂作为原料。 在丝氨酸存在下，使磷脂酶D作为底物作用于天然卵磷脂，由此通过仅一个反应步骤可以容易地获得具有衍生自多元不饱和脂肪酸的侧链的磷脂酰丝氨酸。

    METHOD FOR CONTROLLING CULTURE OF LACTIC BACTERIA
    6.
    发明申请
    METHOD FOR CONTROLLING CULTURE OF LACTIC BACTERIA 审中-公开
    控制细菌培养细菌的方法

    公开(公告)号：WO1997005236A1

    公开(公告)日：1997-02-13

    申请号：PCT/JP1996002093

    申请日：1996-07-25

    Applicant: KABUSHIKI KAISHA YAKULT HONSHA ,  HAYAKAWA, Kazuhito ,  HARADA, Katsuhisa ,  TAKEUCHI, Sogo ,  SHIBATA, Shinya ,  MIYAGI, Akihiko

    Inventor： KABUSHIKI KAISHA YAKULT HONSHA

    IPC: C12N01/20

    CPC classification number: C12N1/20 ,  C12P7/56

    Abstract: A novel method for controlling culture of lactic bacteria, which enables the state of culture of bacteria to be controlled in a simple and rapid manner in the step of cultivation in the production of various products utilizing lactic bacteria. The method is characterized in that, in the step of cultivating lactic bacteria, the intensity of the infrared absorption assignable to dissociable lactic acid and that of the infrared absorption assignable to nondissociable lactic acid in the culture are measured by FT-IR spectrometry and the pH value of the culture and/or the lactic acid concentration of the culture are calculated based on the measurements. The method according to another embodiment is characterized in that, in the above method for controlling culture of lactic bacteria, the intensity of the infrared absorption assignable to glucose as a substrate or an alcoholic C-O group of lactose is measured and the glucose concentration or lactose concentration is calculated based on these measurements. The method according to a further embodiment is characterized in that the intensity of the infrared absorption is measured in-line by the ATR-FT-IR spectrometry and, based on the measurements, the state of culture of lactic bacteria is automatically monitored and controlled.

    Abstract translation: 一种控制乳酸菌培养的新方法，其能够在利用乳酸菌生产各种产品的培养步骤中简单快速地控制细菌的培养状态。 该方法的特征在于，在培养乳酸菌的步骤中，通过FT-IR光谱法测定可分解乳酸的红外吸收强度和赋予培养物中不溶解的乳酸的红外吸收的强度，pH 基于测量计算培养物的pH值和/或培养物的乳酸浓度。 根据另一实施方式的方法的特征在于，在上述控制乳酸菌培养的方法中，测定赋予作为基质的葡萄糖或乳糖的醇类CO基团的红外吸收强度，并且测定葡萄糖浓度或乳糖浓度 基于这些测量计算。 根据另一个实施方案的方法的特征在于通过ATR-FT-IR光谱法在线测量红外吸收的强度，并且基于测量，乳酸菌的培养状态被自动监测和控制。

    PRINTING APPARATUS FOR CONTAINERS OF CIRCULAR CROSS SECTION
    7.
    发明申请
    PRINTING APPARATUS FOR CONTAINERS OF CIRCULAR CROSS SECTION 审中-公开
    圆形横截面集装箱的印刷装置

    公开(公告)号：WO1996035580A1

    公开(公告)日：1996-11-14

    申请号：PCT/JP1996001214

    申请日：1996-05-08

    Applicant: KABUSHIKI KAISHA YAKULT HONSHA ,  NO, Shinichiro ,  WATANABE, Shinichiro

    Inventor： KABUSHIKI KAISHA YAKULT HONSHA

    IPC: B41F17/18

    CPC classification number: B41F17/22 ,  B41F17/18

    Abstract: The invention has its object to effect simultaneous multi-color printing on a container having drum sections recessed from a drum portion by means of a simple construction. To attain such object, according to the invention, a timing screw (35) conveys containers (1), a transfer drum (10) is rotated, a first marking roll (31) transfers ink to stationary shoulder transfer surface portions (11) and stationary drum transfer surface portions (13), a second marking roll transfers ink to movable transfer surface portions (20), and after ink is transferred to shoulder portions (4), drum portion (6) and a neck portion (5) of a container (1) held between a guide (34) and the transfer roll (10) and moved in rotation and printing is performed, a cleaning roll (30) removes the remaining ink on the stationary shoulder transfer surface portions (11), stationary drum transfer surface portions (13) and the movable transfer surface portions (20).

    Abstract translation: 本发明的目的是通过简单的结构在具有从滚筒部分凹陷的鼓部分的容器上同时进行多色打印。 为了达到上述目的，根据本发明，定时螺钉（35）输送容器（1），转印鼓（10）旋转，第一标记辊（31）将油墨转印到固定的肩部转印表面部分（11）和 固定鼓转印表面部分（13），第二标记辊将油墨转移到可移动转印表面部分（20），并且在油墨转印到肩部（4），鼓部分（6）和颈部（5）之后 容器（1）保持在引导件（34）和转印辊（10）之间并旋转并进行打印，清洁辊（30）除去固定的肩部转印表面部分（11），固定鼓 转印表面部分（13）和可移动转印表面部分（20）。

    ANTIBODY-SENSITIZED LATEX USED FOR DETECTING NITRATE OR NITRITE BACTERIA
    8.
    发明申请
    ANTIBODY-SENSITIZED LATEX USED FOR DETECTING NITRATE OR NITRITE BACTERIA 审中-公开
    用于检测硝酸盐或硝酸菌细菌的抗菌敏感性

    公开(公告)号：WO1995025958A1

    公开(公告)日：1995-09-28

    申请号：PCT/JP1995000539

    申请日：1995-03-23

    Applicant: KABUSHIKI KAISHA YAKULT HONSHA ,  ATOBE, Hisao ,  YAGISHITA, Masami ,  OHMURA, Hiroshi ,  NAGAI, Fumiko

    Inventor： KABUSHIKI KAISHA YAKULT HONSHA

    IPC: G01N33/569

    CPC classification number: G01N33/54313 ,  G01N33/56911

    Abstract: An antibody-sensitized latex used for facilitating the detection of nitrate or nitrite bacteria present in activated sludge or soil, which latex comprises an antibody specific for nitrate or nitrite bacteria adsorbed on latex particles having a specific gravity of as high as around 1.5 g/cc or an average diameter of around 1.0 mu m. The latex facilitates the detection of nitrate or nitrite bacteria which has taken a long period of time or has required technical expertize. Further it serves to establish the method of controlling rapidly and suitably the number of active target microbes present in activated sludge or soil.

    Abstract translation: 用于促进检测存在于活性污泥或土壤中的硝酸盐或亚硝酸盐细菌的抗体敏化胶乳，该胶乳包含吸附在比重高达约1.5g / cc的胶乳颗粒上的硝酸盐或亚硝酸盐细菌特异性抗体 或平均直径约为1.0μm。 乳胶有助于检测长时间或需要技术专长的硝酸盐或亚硝酸盐细菌。 此外，它还建立了快速适当地控制活性污泥或土壤中存在的活性目标微生物数量的方法。

    APPARATUS FOR GETTING AN ARTICLE RECEIVED INTO A COVER
    9.
    发明申请
    APPARATUS FOR GETTING AN ARTICLE RECEIVED INTO A COVER 审中-公开
    获取收件人的文章的设备

    公开(公告)号：WO1994014661A1

    公开(公告)日：1994-07-07

    申请号：PCT/JP1993001853

    申请日：1993-12-22

    Applicant: KABUSHIKI KAISHA MURAHARU SEISAKUSHO ,  NIIKURA SCALES CO., LTD. ,  KABUSHIKI KAISHA YAKULT HONSHA ,  MURAKAMI, Toshiyuki

    Inventor： KABUSHIKI KAISHA MURAHARU SEISAKUSHO ,  NIIKURA SCALES CO., LTD. ,  KABUSHIKI KAISHA YAKULT HONSHA

    IPC: B65B67/12

    CPC classification number: A47F13/085 ,  A45B25/24 ,  B65B43/14

    Abstract: An object of the invention is to provide an apparatus which is capable of easily and positively getting an article of food such as French bread and an article for daily use such as umbrellas received into a receiving cover. To this end, the apparatus for getting an article received into a receiving cover according to the invention comprises a plurality of receiving covers adapted to receive a relatively elongated object, a body for containing a plurality of the receiving covers, and means for opening the opening portion of the receiving cover so as to have the object inserted into the receiving cover, said plurality of the receiving covers being loaded in the body of the apparatus while being received in a box. As a result, it is possible according to the invention to easily and positively get an article of food such as French bread and an article for daily use such as umbrellas received into a receiving cover.

    Abstract translation: 本发明的目的是提供一种能够容易且积极地获取诸如法国面包和日常用品如收纳在接收盖中的伞的物品的装置。 为此，根据本发明的用于接纳到接收盖中的物品的装置包括适于容纳相对细长物体的多个接收盖，用于容纳多个接收盖的主体，以及用于打开开口的装置 接收盖的一部分，以便将物体插入到接收盖中，所述多个接收盖在被接收在箱中时被装载在设备的主体中。 结果，根据本发明，可以容易且积极地获得诸如法国面包和日常用品的物品如收纳在接收盖中的伞。

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