公开(公告)号：WO2009066321A2

公开(公告)日：2009-05-28

申请号：PCT/IN2008/000637

申请日：2008-10-03

Applicant: IPCA LABORATORIES LIMITED ,  KUMAR, Ashok ,  SINGH, Dharmendra ,  NELLITHANATH, Thankachen, Byju ,  KADAM, Prasad, Shankar ,  VISHWAKARMA, Harishankar, Prahladkumar ,  OJHA, Vijay ,  NINAWE, Umeshkumar

Inventor： KUMAR, Ashok ,  SINGH, Dharmendra ,  NELLITHANATH, Thankachen, Byju ,  KADAM, Prasad, Shankar ,  VISHWAKARMA, Harishankar, Prahladkumar ,  OJHA, Vijay ,  NINAWE, Umeshkumar

IPC: C07D401/12

CPC classification number: C07D401/12

Abstract: The present invention discloses novel processes for preparing optically active sulphoxide compounds of formula I by asymmetric oxidation of prochiral sulphide compounds of Formula II. More particularly, the invention discloses processes for preparation of optically active proton pump Inhibitors (PPIs) or their optically active precursor (=intermediate) compounds (Formula I) that can be converted into pharmaceutically useful PPIs.

Abstract translation: 本发明公开了通过式II的前手性硫化物化合物的不对称氧化制备式I的光学活性亚砜化合物的新方法。 更具体地，本发明公开了可转化为药学上有用的PPI的光学活性质子泵抑制剂（PPI）或其光学活性前体（=中间体）化合物（式I）的制备方法。

公开(公告)号：WO2009066321A3

公开(公告)日：2011-01-06

申请号：PCT/IN2008000637

申请日：2008-10-03

Applicant: IPCA LAB LTD ,  KUMAR ASHOK ,  SINGH DHARMENDRA ,  NELLITHANATH THANKACHEN BYJU ,  KADAM PRASAD SHANKAR ,  VISHWAKARMA HARISHANKAR PRAHLADKUMAR ,  OJHA VIJAY ,  NINAWE UMESHKUMAR

Inventor： KUMAR ASHOK ,  SINGH DHARMENDRA ,  NELLITHANATH THANKACHEN BYJU ,  KADAM PRASAD SHANKAR ,  VISHWAKARMA HARISHANKAR PRAHLADKUMAR ,  OJHA VIJAY ,  NINAWE UMESHKUMAR

IPC: C07D401/12 ,  C07D235/28

CPC classification number: C07D401/12

Abstract: The present invention discloses novel processes for preparing optically active sulphoxide compounds of formula I by asymmetric oxidation of prochiral sulphide compounds of Formula II. More particularly, the invention discloses processes for preparation of optically active proton pump Inhibitors (PPIs) or their optically active precursor (=intermediate) compounds (Formula I) that can be converted into pharmaceutically useful PPIs.

Abstract translation: 本发明公开了通过式II的前手性硫化物化合物的不对称氧化制备式I的光学活性亚砜化合物的新方法。 更具体地，本发明公开了可转化为药学上有用的PPI的光学活性质子泵抑制剂（PPI）或其光学活性前体（=中间体）化合物（式I）的制备方法。