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1.发明申请EXPRESSION VECTOR ENCODING ALPHAVIRUS REPLICASE AND THE USE THEREOF AS IMMUNOLOGICAL ADJUVANT 审中-公开表达载体编码ALPHAVIRUS REPLICASE及其作为免疫调节剂的用途
公开(公告)号：WO2009141434A1
公开(公告)日：2009-11-26
申请号：PCT/EP2009/056240
申请日：2009-05-22
Applicant: FIT BIOTECH OY , KIIVER, Kaja , SIKUT, Rein , TOOTS, Urve , MÖLDER, Tarmo , MÄNNIK, Andres , USTAV, Mart , KALDMA, Katrin
Inventor： KIIVER, Kaja , SIKUT, Rein , TOOTS, Urve , MÖLDER, Tarmo , MÄNNIK, Andres , USTAV, Mart , KALDMA, Katrin
CPC classification number: A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/005 , C07K2319/09 , C12N7/00 , C12N9/127 , C12N2710/20022 , C12N2770/36122
Abstract: The present invention relates to an alphaviral replicase, especially Semliki Forest Virus replicase, or an expression vector encoding an alphaviral replicase, said alphaviral replicase comprising RNA dependent RNA polymerase activity, for use as an immune system modulating adjuvant. The alphaviral replicase may be used in the combination with a vaccine providing an adjuvant function therein, which when present therein will generate an additional boost to the immune response in the subject to whom this combination is administered as compared to when the vaccine alone is administered to a subject in need thereof. The aim of the present invention is to provide an efficient and easy to administer, species-independent adjuvant which will provide advantages to the adjuvants used together with vaccines today.
Abstract translation: 本发明涉及甲病毒复制酶，特别是塞米利奇森林病毒复制酶，或编码甲病毒复制酶的表达载体，所述甲病毒复制酶包含RNA依赖性RNA聚合酶活性，用作免疫系统调节佐剂。 甲病毒复制酶可以与提供其中的佐剂功能的疫苗组合使用，当其中存在时，其将在给予该组合的受试者中产生额外的促进作用，与将单独的疫苗施用于 有需要的科目。 本发明的目的是提供一种有效和易于施用的与物种无关的佐剂，其将为今天与疫苗一起使用的佐剂提供优点。
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2.发明申请EXPRESSION VECTOR ENCODING ALPHAVIRUS REPLICASE AND THE USE THEREOF AS IMMUNOLOGICAL ADJUVANT 审中-公开表达载体编码ALPHAVIRUS REPLICASE及其作为免疫调节剂的用途
公开(公告)号：WO2009141434A4
公开(公告)日：2010-01-14
申请号：PCT/EP2009056240
申请日：2009-05-22
Applicant: FIT BIOTECH OY , KIIVER KAJA , SIKUT REIN , TOOTS URVE , MOELDER TARMO , MAENNIK ANDRES , USTAV MART , KALDMA KATRIN
Inventor： KIIVER KAJA , SIKUT REIN , TOOTS URVE , MOELDER TARMO , MAENNIK ANDRES , USTAV MART , KALDMA KATRIN
CPC classification number: A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/005 , C07K2319/09 , C12N7/00 , C12N9/127 , C12N2710/20022 , C12N2770/36122
Abstract: The present invention relates to an alphaviral replicase, especially Semliki Forest Virus replicase, or an expression vector encoding an alphaviral replicase, said alphaviral replicase comprising RNA dependent RNA polymerase activity, for use as an immune system modulating adjuvant. The alphaviral replicase may be used in the combination with a vaccine providing an adjuvant function therein, which when present therein will generate an additional boost to the immune response in the subject to whom this combination is administered as compared to when the vaccine alone is administered to a subject in need thereof. The aim of the present invention is to provide an efficient and easy to administer, species-independent adjuvant which will provide advantages to the adjuvants used together with vaccines today.
Abstract translation: 本发明涉及甲病毒复制酶，特别是塞米利奇森林病毒复制酶，或编码甲病毒复制酶的表达载体，所述甲病毒复制酶包含RNA依赖性RNA聚合酶活性，用作免疫系统调节佐剂。 甲病毒复制酶可以与提供其中的佐剂功能的疫苗组合使用，当其中存在时，其将在给予该组合的受试者中产生额外的促进作用，与将单独的疫苗施用于 有需要的科目。 本发明的目的是提供一种有效和易于施用的与物种无关的佐剂，其将为今天与疫苗一起使用的佐剂提供优点。
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