公开(公告)号：WO2009119980A2

公开(公告)日：2009-10-01

申请号：PCT/KR2009001095

申请日：2009-03-05

申请人： CHONG KUN DANG PHARM CORP ,  CHOI NAM-SONG ,  KIM YOUNG-HOON ,  LEE JAE-KWANG ,  KANG HEE-RYONG ,  CHOI HO-JIN ,  MOON SEUNG-KEE ,  KIM SOO-JIN ,  PARK GYU-TAE ,  HAN BYEONG-HOON ,  KIM DAL-HYUN ,  CHOI JAE-HOON ,  LEE SUNG-SOOK ,  AHN SOON-KIL ,  LEE KYUNG-JOO ,  BAE SU-YEAL

发明人： CHOI NAM-SONG ,  KIM YOUNG-HOON ,  LEE JAE-KWANG ,  KANG HEE-RYONG ,  CHOI HO-JIN ,  MOON SEUNG-KEE ,  KIM SOO-JIN ,  PARK GYU-TAE ,  HAN BYEONG-HOON ,  KIM DAL-HYUN ,  CHOI JAE-HOON ,  LEE SUNG-SOOK ,  AHN SOON-KIL ,  LEE KYUNG-JOO ,  BAE SU-YEAL

IPC分类号： C07D417/10

CPC分类号： C07D417/10 ,  C07D417/14

摘要： The present invention relates to novel benzophenone thiazole derivatives of chemical formula 1, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof or solvates thereof, pharmaceutical compositions containing the same, use thereof as therapeutic agents and a method for producing the same. The benzophenone thiazole derivatives of the present invention have inhibitory activities against the formation of microtubules, and exterminate active proliferating cells of malignant tumors and thus can be used in treating the general growth state of a malignant tumor. R, R1 and R2 in chemical formula 1 are the same as those defined in the description of the invention.

摘要翻译： 本发明涉及化学式1的新型二苯甲酮噻唑衍生物，其异构体，其药学上可接受的盐，其水合物或溶剂合物，含有它们的药物组合物，作为治疗剂的用途及其制备方法。 本发明的二苯甲酮噻唑衍生物具有抗微管形成的抑制活性，能够消除恶性肿瘤的活性增殖细胞，可用于治疗恶性肿瘤的一般生长状态。 化学式1中的R，R 1和R 2与本发明的说明书中定义的相同。