公开(公告)号：WO1996020205A1

公开(公告)日：1996-07-04

申请号：PCT/US1995016434

申请日：1995-12-21

Applicant: UNIVERSITY OF CINCINNATI ,  WILSON, Robert, Marshall ,  SCHNAPP, Karlyn, A. ,  HARSCH, Andreas ,  KELLER, Stephen, J. ,  SCHLEMM, Donna, J.

Inventor： UNIVERSITY OF CINCINNATI

IPC: C07H21/00

CPC classification number: C07D319/14

Abstract: The present invention relates to a class of 1,4-dihydrodioxin masked quinone compounds which are useful as DNA or RNA cleaving reagents. These compounds may additionally include moieties which target the compounds to specific base sequences on the DNA or RNA molecule to permit site-specific cleavage. The process for using these compounds in a UV or short wavelength visible light-activated reaction for cleaving DNA, as well as pharmaceutical compositions containing these compounds, are also disclosed.

Abstract translation: 本发明涉及可用作DNA或RNA切割试剂的一类1,4-二氢二恶英掩蔽的醌化合物。 这些化合物还可以包括将化合物靶向DNA或RNA分子上的特定碱基序列以允许位点特异性切割的部分。 还公开了在UV或短波长可见光激活反应中使用这些化合物以切割DNA的方法，以及含有这些化合物的药物组合物。

公开(公告)号：WO1991018999A1

公开(公告)日：1991-12-12

申请号：PCT/US1991003491

申请日：1991-05-17

Applicant: LEVIN, Robert, H. ,  KELLER, Stephen, J.

IPC: C12P21/04

CPC classification number: C07K14/395 ,  A61K38/00 ,  C07K14/485

Abstract: A yeast-derived Epidermal Growth Factor-like composition having an equivalency of from about 1000 to at least 943000 nanograms of murine-derived Epidermal Growth Factor activity per milligram of said composition, and processes for the production and assay of said composition. Dosage compositions for both topical and oral application are also provided.

Abstract translation: 具有约1000至至少943000纳克每毫克所述组合物的鼠衍生的表皮生长因子活性的等同物的酵母衍生的表皮生长因子样组合物，以及所述组合物的生产和测定方法。 还提供了用于局部和口服应用的剂量组合物。