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    NOVEL HYBRID PROMOTER AND RECOMBINANT VECTOR COMPRISING THE SAME
    1.
    发明申请
    NOVEL HYBRID PROMOTER AND RECOMBINANT VECTOR COMPRISING THE SAME 审中-公开
    新型混合启动器和包含它的重组载波

    公开(公告)号：WO2012074277A3

    公开(公告)日：2012-08-09

    申请号：PCT/KR2011009166

    申请日：2011-11-29

    Applicant: LG LIFE SCIENCES LTD ,  KIM YEON CHUL ,  JUNG SAEM ,  JUNG JUN

    Inventor： KIM YEON CHUL ,  JUNG SAEM ,  JUNG JUN

    IPC: C12N15/63 ,  A61K48/00 ,  C12N15/85

    CPC classification number: C12N15/85 ,  C12N2830/15 ,  C12N2830/36 ,  C12N2830/42 ,  C12N2830/60 ,  C12N2830/80 ,  C12N2830/85

    Abstract: The present invention relates to a hybrid promoter, in which a whole or a part of a CMV enhancer, a whole or a part of a ß-actin promoter, a whole or a part of a CMV promoter, and a whole or a part of a ß-actin intron are operably linked to each other, a recombinant vector comprising the same, a transformant transformed with the recombinant vector, a pharmaceutical composition comprising the recombinant vector or the transformant, and a method for preparing a target protein using the recombinant vector or the transformant. The hybrid promoter of the present invention is able to induce high expression of a target protein in a eukaryotic cell. Therefore, the hybrid promoter of the present invention can be effectively used for the development of an antibody or the production of a DNA vaccine.

    Abstract translation: 本发明涉及杂合启动子，其中CMV增强子的全部或部分，β-肌动蛋白启动子的全部或一部分，CMV启动子的全部或一部分，以及整个或部分 β-肌动蛋白内含子彼此可操作地连接，包含所述重组载体的重组载体，包含所述重组载体的转化体，包含所述重组载体或所述转化体的药物组合物，以及使用所述重组载体制备靶蛋白的方法 或转化体。 本发明的杂合启动子能够在真核细胞中诱导靶蛋白的高表达。 因此，本发明的杂合启动子可以有效地用于开发抗体或生产DNA疫苗。

    IMMUNOASSAY FOR PLASMODIUM FALCIPARUM AND ASSAY DEVICE USED THEREFOR
    2.
    发明申请
    IMMUNOASSAY FOR PLASMODIUM FALCIPARUM AND ASSAY DEVICE USED THEREFOR 审中-公开
    用于其中的PLASMODIUM FALCIPARUM和测定装置的免疫测定

    公开(公告)号：WO2006004332A1

    公开(公告)日：2006-01-12

    申请号：PCT/KR2005/002010

    申请日：2005-06-28

    Applicant: LG LIFE SCIENCES LTD. ,  SOHN, Mi Jin ,  YOO, Seung Bum ,  KIM, Yeon Chul ,  OH, Jae Hoon ,  KIM, Eunkyung ,  CHOO, Seung Ho

    Inventor： SOHN, Mi Jin ,  YOO, Seung Bum ,  KIM, Yeon Chul ,  OH, Jae Hoon ,  KIM, Eunkyung ,  CHOO, Seung Ho

    IPC: G01N33/549

    CPC classification number: G01N33/56905 ,  G01N33/543 ,  G01N2333/445 ,  Y02A50/58

    Abstract: Disclosed are an immunoassay of Plasmodium falciparum for determining the presence/absence of a specific and/or antibody thereof vialabel in conjugates bound to the specific antigen and/or antibody present in a sample, comprising immobilizing the specific antigen and antibody of Plasmodium falciparum on a solid phase, adding a sample obtained from a subject of interest to the solid phase so as to induce specific antibody-antigen reaction, adding a conjugate of the antigen and alabel and a conjugate of the antibody and a label, separately prepared, so as to induce binding of at least one of the conjugates; and an assay device comprising the above-mentioned solid phase and conjugates. The present invention can effect specific detection of antigens and/or antibodies in patients with manifested malaria-symptoms as well as malaria carriers and can also be efficiently employed in samples at the early stage of malaria infection that is difficult to detect via conventional arts. Further, due to the capacity to utilize sera and blood plasma rather than whole blood, the present invention is well suited to large-scale examination such as blood screening.

    Abstract translation: 披露的是i的免疫测定

    NOVEL HYBRID PROMOTER AND RECOMBINANT VECTOR COMPRISING THE SAME
    3.
    发明申请
    NOVEL HYBRID PROMOTER AND RECOMBINANT VECTOR COMPRISING THE SAME 审中-公开
    新型混合动力推进器和包含其的重组矢量

    公开(公告)号：WO2012074277A2

    公开(公告)日：2012-06-07

    申请号：PCT/KR2011/009166

    申请日：2011-11-29

    Applicant: LG LIFE SCIENCES LTD. ,  KIM, Yeon Chul ,  JUNG, Saem ,  JUNG, Jun

    Inventor： KIM, Yeon Chul ,  JUNG, Saem ,  JUNG, Jun

    IPC: C12N15/63 ,  C12N15/85 ,  A61K48/00

    CPC classification number: C12N15/85 ,  C12N2830/15 ,  C12N2830/36 ,  C12N2830/42 ,  C12N2830/60 ,  C12N2830/80 ,  C12N2830/85

    Abstract: The present invention relates to a hybrid promoter, in which a whole or a part of a CMV enhancer, a whole or a part of a β-actin promoter, a whole or a part of a CMV promoter, and a whole or a part of a β-actin intron are operably linked to each other, a recombinant vector comprising the same, a transformant transformed with the recombinant vector, a pharmaceutical composition comprising the recombinant vector or the transformant, and a method for preparing a target protein using the recombinant vector or the transformant. The hybrid promoter of the present invention is able to induce high expression of a target protein in a eukaryotic cell. Therefore, the hybrid promoter of the present invention can be effectively used for the development of an antibody or the production of a DNA vaccine.

    Abstract translation: 本发明涉及一种杂交启动子，其中全部或部分CMV增强子，ß-肌动蛋白启动子的全部或部分，全部或部分CMV启动子，以及全部或部分 β-肌动蛋白内含子彼此可操作地连接，包含其的重组载体，用重组载体转化的转化体，包含重组载体或转化体的药物组合物，以及使用重组载体制备靶蛋白的方法 或转化体。 本发明的杂交启动子能够在真核细胞中诱导靶蛋白的高表达。 因此，本发明的杂交启动子可以有效地用于抗体的制备和DNA疫苗的制备。

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