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    METHOD FOR PREPARATION OF 3-ALKYLTHIO-2-BROMOPYRIDINE
    2.
    发明申请
    METHOD FOR PREPARATION OF 3-ALKYLTHIO-2-BROMOPYRIDINE 审中-公开
    制备3-甲基-L-溴代吡啶的方法

    公开(公告)号：WO2015053576A1

    公开(公告)日：2015-04-16

    申请号：PCT/KR2014/009508

    申请日：2014-10-10

    Applicant: LG LIFE SCIENCES LTD.

    Inventor： AHN, Sei Chang ,  KIM, Sook Hee ,  KADIVENDI, Sadaiah ,  LEE, Seo Yeon ,  KIM, Ki Dae ,  RYU, In Ae

    IPC: C07D213/32 ,  A01N43/40 ,  A01P21/00

    CPC classification number: A01N47/36 ,  C07C323/60 ,  C07D213/32 ,  C07D295/145

    Abstract: The present invention relates to a novel method for the preparation of a key intermediate pyridine compound for producing fluoroalkylpyridine-sulfonyl urea derivatives showing superior herbicidal activity, novel alkylthioolefin derivatives used in the preparation, and a method for the preparation thereof. According to the present method using the novel alkylthioolefin derivatives of Formula 2, the intermediate compound of Formula 1 for producing flucetosulfuron can be prepared, through a simple processing step, with a yield equivalent or superior to those of conventional methods.

    Abstract translation: 本发明涉及一种制备用于制备显示出优异除草活性的氟代烷基吡啶 - 磺酰脲衍生物的关键中间体吡啶化合物的新方法，用于制备的新型烷基硫代烯烃衍生物及其制备方法。 根据本发明的使用式2的烷基硫代烯烃衍生物的方法，可以通过简单的加工步骤以等同于或高于常规方法的产率制备用于制备氟磺草酮的式1的中间体化合物。

    COMBINATION DRUG COMPRISING GEMIGLIPTIN AND METFORMIN, AND METHOD FOR THE PREPARATION THEREOF
    4.
    发明申请
    COMBINATION DRUG COMPRISING GEMIGLIPTIN AND METFORMIN, AND METHOD FOR THE PREPARATION THEREOF 审中-公开
    包含GEMIGLIPTIN和METFORMIN的组合药物及其制备方法

    公开(公告)号：WO2014058188A1

    公开(公告)日：2014-04-17

    申请号：PCT/KR2013/008932

    申请日：2013-10-07

    Applicant: LG LIFE SCIENCES LTD.

    Inventor： KIM, Geun Tae ,  YUN, Duck Il ,  PARK, Ki Sook

    IPC: A61K9/24 ,  A61K9/20 ,  A61K31/155

    CPC classification number: A61K31/155 ,  A61K9/209 ,  A61K31/517 ,  A61K2300/00

    Abstract: The present invention relates to a combination drug comprising gemigliptin and metformin as active components and a method for the preparation thereof. The pharmaceutical composition consisting of a first layer comprising metformin and a second layer comprising gemigliptin according to the present invention has a superior effect on the prevention and treatment of diabetes and their complex diseases, and reduces the adverse effects of each component. In addition, the present composition comprises gemigliptin and metformin in a separated form so as to maintain the inherent dissolution rates of both components and improve patient compliance.

    Abstract translation: 本发明涉及包含吉西他宁和二甲双胍作为活性成分的组合药物及其制备方法。 由包含二甲双胍的第一层和包含根据本发明的吉格列汀的第二层组成的药物组合物对预防和治疗糖尿病及其复杂疾病具有优异的作用，并且降低了每种组分的不利影响。 此外，本发明的组合物包含分离形式的吉西他宁和二甲双胍，以保持两种成分的固有溶解速率并改善患者依从性。

    NOVEL HYBRID PROMOTER AND RECOMBINANT VECTOR COMPRISING THE SAME
    5.
    发明申请
    NOVEL HYBRID PROMOTER AND RECOMBINANT VECTOR COMPRISING THE SAME 审中-公开
    新型混合动力推进器和包含其的重组矢量

    公开(公告)号：WO2012074277A2

    公开(公告)日：2012-06-07

    申请号：PCT/KR2011/009166

    申请日：2011-11-29

    Applicant: LG LIFE SCIENCES LTD. ,  KIM, Yeon Chul ,  JUNG, Saem ,  JUNG, Jun

    Inventor： KIM, Yeon Chul ,  JUNG, Saem ,  JUNG, Jun

    IPC: C12N15/63 ,  C12N15/85 ,  A61K48/00

    CPC classification number: C12N15/85 ,  C12N2830/15 ,  C12N2830/36 ,  C12N2830/42 ,  C12N2830/60 ,  C12N2830/80 ,  C12N2830/85

    Abstract: The present invention relates to a hybrid promoter, in which a whole or a part of a CMV enhancer, a whole or a part of a β-actin promoter, a whole or a part of a CMV promoter, and a whole or a part of a β-actin intron are operably linked to each other, a recombinant vector comprising the same, a transformant transformed with the recombinant vector, a pharmaceutical composition comprising the recombinant vector or the transformant, and a method for preparing a target protein using the recombinant vector or the transformant. The hybrid promoter of the present invention is able to induce high expression of a target protein in a eukaryotic cell. Therefore, the hybrid promoter of the present invention can be effectively used for the development of an antibody or the production of a DNA vaccine.

    Abstract translation: 本发明涉及一种杂交启动子，其中全部或部分CMV增强子，ß-肌动蛋白启动子的全部或部分，全部或部分CMV启动子，以及全部或部分 β-肌动蛋白内含子彼此可操作地连接，包含其的重组载体，用重组载体转化的转化体，包含重组载体或转化体的药物组合物，以及使用重组载体制备靶蛋白的方法 或转化体。 本发明的杂交启动子能够在真核细胞中诱导靶蛋白的高表达。 因此，本发明的杂交启动子可以有效地用于抗体的制备和DNA疫苗的制备。

    NON-AQUEOUS OILY INJECTABLE FORMULATION EXHIBITING PRESERVATIVE EFFICACY
    6.
    发明申请
    NON-AQUEOUS OILY INJECTABLE FORMULATION EXHIBITING PRESERVATIVE EFFICACY 审中-公开
    显示出保水效果的非水性油性注射剂

    公开(公告)号：WO2012036430A2

    公开(公告)日：2012-03-22

    申请号：PCT/KR2011006707

    申请日：2011-09-09

    Applicant: LG LIFE SCIENCES LTD ,  SO JIN EON ,  YEO DONG JUN ,  JANG YOON-SEON

    Inventor： SO JIN EON ,  YEO DONG JUN ,  JANG YOON-SEON

    IPC: A61K9/113 ,  A61K9/107 ,  A61K31/728

    CPC classification number: A61K47/10 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/728 ,  A61K47/14

    Abstract: Disclosed herein is preferably a multi-dose type non-aqueous oily injectable formulation including; an active ingredient (drug) expressing therapeutic effects, which is dissolved, dispersed or suspended in a therapeutically effective amount, in oil. The disclosed non-aqueous oily injectable formulation may include; an oil-affinitive preservative, and a hydrophilic excipient non-phase separable from the oil-affinitive preservative when the excipient is mixed with the oil-affinitive preservative.

    Abstract translation: 本文公开了优选多剂量型非水性油性可注射制剂，其包含： 将表达治疗效果的活性成分（药物）溶解，分散或悬浮于治疗有效量的油中。 所公开的非水性油性注射制剂可以包括; 亲油防腐剂和当赋形剂与油亲和防腐剂混合时可与亲油防腐剂无相分离的亲水赋形剂。

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