公开(公告)号：WO2005087250A1

公开(公告)日：2005-09-22

申请号：PCT/US2004/004142

申请日：2004-02-12

Applicant: NATIONAL INSTITUTES OF HEALTH ,  CSAKY, Karl, G. ,  KLEINMAN, Hynda ,  PONCE, Lourdes

Inventor： CSAKY, Karl, G. ,  KLEINMAN, Hynda ,  PONCE, Lourdes

IPC: A61K38/00

CPC classification number: A61K38/08 ,  A61K38/10 ,  C07K5/101 ,  C07K5/1016 ,  C07K14/78

Abstract: Unregulated angiogenesis is associated with a variety of pathological conditions. Tumor growth and metastasis is dependent on the development of new blood vessels. The development of new blood vessels in the eye, or ocular neovascularization, has been implicated in a variety of serious ocular diseases. For instance, choroidal neovascularization is linked to age-related macular degeneration, while retinal neovascularization is linked to diabetic retinopathy. The present invention is based on the discovery of a peptide sequence, C16Y, which inhibits ocular neovascularization and tumor growth in vivo . C16Y is a scrambled version of the C16 peptide sequence from the y1 chain of laminin-1. Unlike C16, which is an angiogenic stimulator, C16Y has been shown to inhibit angiogenesis. The present invention discloses methods of treating ocular neovascularization and cancer using both full-length and truncated versions of the C16Y.

Abstract translation: 不规则的血管发生与多种病理状况有关。 肿瘤生长和转移取决于新血管的发育。 眼睛中新血管的发展或眼睛新生血管形成已经涉及各种严重的眼部疾病。 例如，脉络膜新生血管形成与年龄相关的黄斑变性相关，而视网膜新生血管形成与糖尿病性视网膜病变相关。 本发明基于肽体系C16Y的发现，C16Y抑制体内新生血管形成和肿瘤生长。 C16Y是来自层粘连蛋白-1的y1链的C16肽序列的加扰版本。 不同于作为血管生成刺激物的C16，C16Y已被证明可以抑制血管发生。 本发明公开了使用全长和截短版本的C16Y治疗眼新生血管形成和癌症的方法。

公开(公告)号：WO2003063775A2

公开(公告)日：2003-08-07

申请号：PCT/US2003/001973

申请日：2003-01-22

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  PHILP, Deborah ,  KLEINMAN, Hynda, K. ,  ELKIN, Michael

Inventor： PHILP, Deborah ,  KLEINMAN, Hynda, K. ,  ELKIN, Michael

IPC: A61K

CPC classification number: A61K8/64 ,  A61K38/2292 ,  A61Q7/00

Abstract: Disclosed herein are methods and compositions suitable for the promotion of hair growth on humans and other animals. Disclosed embodiments include compositions comprising actin-binding peptides. In some embodiments, the actin-binding peptides comprise fragments of thymosin β 4 . In other embodiments, the disclosure provides compositions comprising fragments of thymosin β 4 and/or other actin-binding peptides that are suitable for the treatment of alopecia and other conditions associated with hair loss. In still further embodiments, the disclosure provides compositions comprising the sequence of approximately six or seven amino acids of the thymosin β 4 sequence that bind actin.

Abstract translation: 本文公开了适用于促进人类和其他动物的毛发生长的方法和组合物。 所公开的实施方案包括含有肌动蛋白结合肽的组合物。 在一些实施方案中，肌动蛋白结合肽包含胸腺素β4的片段。 在其他实施方案中，本公开提供了包含胸腺素β4和/或其他肌动蛋白结合肽片段的组合物，其适用于治疗与脱发相关的脱发和其他病症。 在更进一步的实施方案中，本公开提供了组合物，其包含结合肌动蛋白的胸腺素β_4序列的大约六或七个氨基酸的序列。

公开(公告)号：WO2003018014A3

公开(公告)日：2003-03-06

申请号：PCT/US2002/026909

申请日：2002-08-23

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  PARK, Myung, Hee ,  CLEMENT, Paul, M. ,  HANAUSKE-ABEL, Hartmut, M. ,  WOLF, Edith, C. ,  KLEINMAN, Hynda, K. ,  CRACCHIOLO, Bernadette, M.

Inventor： PARK, Myung, Hee ,  CLEMENT, Paul, M. ,  HANAUSKE-ABEL, Hartmut, M. ,  WOLF, Edith, C. ,  KLEINMAN, Hynda, K. ,  CRACCHIOLO, Bernadette, M.

IPC: A61K31/44

Abstract: A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.

公开(公告)号：WO2013003234A1

公开(公告)日：2013-01-03

申请号：PCT/US2012/043824

申请日：2012-06-22

Applicant: TREVIGEN, INC. ,  GEORGE, Jay ,  KLEINMAN, Hynda

Inventor： GEORGE, Jay ,  KLEINMAN, Hynda

IPC: C12N5/09

CPC classification number: C12N5/0068 ,  C12N5/0693 ,  C12N2533/90

Abstract: The present invention relates to a tumor matrix comprising extracellular matrix components from a basement membrane, stroma, and tumor, that promotes tumor cell growth in vitro and in vivo reflective of the tumor type. Also disclosed are methods for the preparation of the tumor matrix.

Abstract translation: 本发明涉及包含来自基底膜，基质和肿瘤的细胞外基质成分的肿瘤基质，其促进反映肿瘤类型的体外和体内的肿瘤细胞生长。 还公开了用于制备肿瘤基质的方法。

公开(公告)号：WO03018014A2

公开(公告)日：2003-03-06

申请号：PCT/US0226909

申请日：2002-08-23

Applicant: US GOV HEALTH & HUMAN SERV ,  PARK MYUNG HEE ,  CLEMENT PAUL M ,  HANAUSKE-ABEL HARTMUT M ,  WOLF EDITH C ,  KLEINMAN HYNDA K ,  CRACCHIOLO BERNADETTE M

Inventor： PARK MYUNG HEE ,  CLEMENT PAUL M ,  HANAUSKE-ABEL HARTMUT M ,  WOLF EDITH C ,  KLEINMAN HYNDA K ,  CRACCHIOLO BERNADETTE M

IPC: A61K31/16 ,  A61K31/44 ,  A61K31/4412 ,  A61P35/00

CPC classification number: A61K31/16 ,  A61K31/44 ,  A61K31/4412

Abstract: A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.

Abstract translation: 一种抑制组织中血管通道形成的方法和一种抑制非血管化上皮内瘤形成细胞增殖的方法，两种方法都包括给予组织或细胞化合物。

公开(公告)号：WO03018014A9

公开(公告)日：2003-12-11

申请号：PCT/US0226909

申请日：2002-08-23

Applicant: US GOV HEALTH & HUMAN SERV ,  PARK MYUNG HEE ,  CLEMENT PAUL M ,  HANAUSKE-ABEL HARTMUT M ,  WOLF EDITH C ,  KLEINMAN HYNDA K ,  CRACCHIOLO BERNADETTE M

Inventor： PARK MYUNG HEE ,  CLEMENT PAUL M ,  HANAUSKE-ABEL HARTMUT M ,  WOLF EDITH C ,  KLEINMAN HYNDA K ,  CRACCHIOLO BERNADETTE M

IPC: A61K31/16 ,  A61K31/44 ,  A61K31/4412 ,  A61P35/00

CPC classification number: A61K31/16 ,  A61K31/44 ,  A61K31/4412

Abstract: A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.

Abstract translation: 抑制组织中血管通道形成的方法和抑制非血管化上皮内瘤变细胞增殖的方法，所述方法包括向组织或细胞施用化合物。

公开(公告)号：WO2003063775A3

公开(公告)日：2003-08-07

申请号：PCT/US2003/001973

申请日：2003-01-22

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  PHILP, Deborah ,  KLEINMAN, Hynda, K. ,  ELKIN, Michael

Inventor： PHILP, Deborah ,  KLEINMAN, Hynda, K. ,  ELKIN, Michael

IPC: A61K7/06

Abstract: Disclosed herein are methods and compositions suitable for the promotion of hair growth on humans and other animals. Disclosed embodiments include compositions comprising actin-binding peptides. In some embodiments, the actin-binding peptides comprise fragments of thymosin β 4 . In other embodiments, the disclosure provides compositions comprising fragments of thymosin β 4 and/or other actin-binding peptides that are suitable for the treatment of alopecia and other conditions associated with hair loss. In still further embodiments, the disclosure provides compositions comprising the sequence of approximately six or seven amino acids of the thymosin β 4 sequence that bind actin.