公开(公告)号：WO1994011069A1

公开(公告)日：1994-05-26

申请号：PCT/GB1992002107

申请日：1992-11-13

Applicant: KOSMIN, Gerald, Emmanuel ,  ROBO SPORTS TECHNOLOGIES PTY. LIMITED ,  ELBAUM, Daniel

Inventor： KOSMIN, Gerald, Emmanuel ,  ROBO SPORTS TECHNOLOGIES PTY. LIMITED

IPC: A63B69/40

CPC classification number: A63B69/406 ,  A63B69/40

Abstract: A machine which can be used by a player practising a ball game such as tennis or badminton has an ejection mechanism comprising a pair of revolving discs (1a, 1b) spaced apart by a gap (2) through which can be drawn a ball (4) for ejection in a direction (3) which can be determined by appropriate adjustment of the vertical and horizontal positioning of the revolving discs by means of inclination drive (10) and sweep gear (12). Side spin or slice can be imparted to the ball by rotation of the revolving discs about an axis lying in the direction (3) of the ball ejection, whilst top spin or under spin can be imparted to the ball by varying the angular velocity of the discs (1a, 1b) by causing them to rotate at differing speeds. The ejection mechanism may be mounted on a height adjusting mechanism in order to vary the height at which the ball is ejected. The machine can be controlled by a microprocessor-based system which may be pre-programmed or operated by remote control.

Abstract translation: 可以由练习网球或羽毛球等玩家的玩家使用的机器具有弹出机构，其包括由间隙（2）间隔开的一对旋转盘（1a，1b），通过该间隙可以将球（4） ），用于通过借助于倾斜驱动（10）和扫掠齿轮（12）适当调节旋转盘的垂直和水平定位来确定的方向（3）上的喷射。 侧旋转或切片可以通过旋转盘围绕球排出的方向（3）的轴旋转而赋予球，而顶部旋转或下旋转可以通过改变球的角速度来赋予球 通过使盘（1a，1b）以不同的速度旋转。 弹出机构可以安装在高度调节机构上，以便改变球的弹出高度。 机器可以由基于微处理器的系统控制，该系统可以通过远程控制进行预编程或操作。

公开(公告)号：WO1995003303A2

公开(公告)日：1995-02-02

申请号：PCT/GB1994001543

申请日：1994-07-15

Applicant: KOSMIN, Gerald, Emmanuel ,  STATE OF ISRAEL, represented by THE PRIME MINISTER'S OFFICE, ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH ,  FISHER, Abraham ,  KARTON, Yishal ,  MARCIANO, Daniele ,  BARAK, Dov ,  MESHULAM, Haim

Inventor： KOSMIN, Gerald, Emmanuel ,  STATE OF ISRAEL, represented by THE PRIME MINISTER'S OFFICE, ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH

IPC: C07D471/10

CPC classification number: C07D471/10 ,  C07D491/10 ,  C07D497/10 ,  C07D513/10

Abstract: The invention relates to spiro compounds having central and peripheral nervous system activity, for example muscarinic agonist activity, having formulae (I, II, III, IV, V, VI, VII, VIII and IX) and their pharmaceutically acceptable salts, quaternary compounds which are structurally derived from said compounds having a tertiary nitrogen atom, enantiomers and racemates, wherein ring A together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms, and the value of each of the other symbols in the formulae is defined.

Abstract translation: 本发明涉及具有中枢和周围神经系统活性的螺环化合物，例如毒蕈碱激动剂活性，具有式（I，II，III，IV，V，VI，VII，VIII和IX）及其药学上可接受的盐， 在结构上衍生自具有叔氮原子，对映异构体和外消旋体的所述化合物，其中环A与螺 - 碳原子一起构成含有一个或两个环氮原子的桥连或非桥连环，并且其中每个其它符号的值 定义公式。

公开(公告)号：WO1996041093A1

公开(公告)日：1996-12-19

申请号：PCT/GB1995001329

申请日：1995-06-07

Applicant: ZINKAL LTD. ,  KOSMIN, Gerald, Emmanuel ,  SHENKAR, Roy ,  STERNFELD, Yehuda

Inventor： ZINKAL LTD. ,  KOSMIN, Gerald, Emmanuel

IPC: F16L37/02

CPC classification number: F16L37/025 ,  A01G9/245 ,  F16L37/148 ,  F28F1/16 ,  F28F9/264 ,  Y02A40/268

Abstract: A quick assembly heating system comprises a combination as required of: (1) a plurality of substantially smooth conduit lengths each having a male end portion and a female end portion of a larger internal diameter than the corresponding male end portion, each male end portion being formed with at least one recessed annular groove and each female end portion being formed with at least two protruding annular grooves, one of which serves in use to accommodate a sealing gasket and the other of which serves in use to form with a recessed annular groove of said male end portion of an adjoining conduit length an annular cavity into which a flexible elastomeric securing rod can be fed through an aperture formed in the annular groove; (2) and a plurality of pipe sections each provided with one or more heat dissipating fins.

Abstract translation: 快速组装加热系统包括以下组合：（1）多个基本上平滑的管道长度，每个管道长度分别具有比相应的公端部更大内径的阳端部分和阴端部分，每个阳端部分为 形成有至少一个凹入的环形凹槽，并且每个阴端部分形成有至少两个突出的环形凹槽，其中一个用于容纳密封垫片，另一个用于容纳密封垫片，另一个用于形成具有凹陷的环形凹槽 相邻导管的所述阳端部长度为环形空腔，柔性弹性体固定杆可以通过形成在环形槽中的孔进给到其中; （2）和多个管段，每个管段设有一个或多个散热翅片。

公开(公告)号：WO1994022483A2

公开(公告)日：1994-10-13

申请号：PCT/GB1994000669

申请日：1994-03-30

Applicant: KOSMIN, Gerald, Emmanuel ,  D-PHARM, LTD. ,  KOZAK, Alexander

Inventor： KOSMIN, Gerald, Emmanuel ,  D-PHARM, LTD.

IPC: A61K47/48

CPC classification number: C07F9/10 ,  A61K47/54 ,  A61K47/542 ,  A61K47/544

Abstract: The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to intracellular enzyme activity. The prodrug may be used in a technique for treating a condition or disease in a human related to supranormal intracellular enzyme (e.g. phospholipase and/or esterase) activity, whereby on administering it to a human having such condition or disease, the bond is broken in response to such activity, and the pharmacologically active compound accumulates selectively within cells having such supranormal intracellular enzyme activity. Exemplary conjugates are esters of the carboxylic function in the formula, with e.g. heptanoyl-sn-3-glycerophosphoryl-choline or octanoyl-sn-3-glycerophosphoryl-choline.

Abstract translation: 本发明涉及药学上可接受的前体药物，其是药理学活性化合物和细胞内运输佐剂的共价缀合物，其特征在于存在对细胞内酶活性具有断裂敏感性的共价键。 该前体药物可用于治疗与超细胞内酶（例如磷脂酶和/或酯酶）活性相关的人的病症或疾病的技术，由此在将其施用于具有这种病症或疾病的人时，该结合被破坏 对这种活性的反应，并且药理活性化合物选择性地在具有这种超常规细胞内酶活性的细胞内积累。 共轭物是式中羧基官能团的酯， 庚酰基-sn-3-甘油磷酰胆碱或辛酰基-sn-3-甘油磷酰胆碱。

公开(公告)号：WO1994021332A1

公开(公告)日：1994-09-29

申请号：PCT/GB1993000547

申请日：1993-03-17

Applicant: KOSMIN, Gerald, Emmanuel ,  ELBAUM, Daniel ,  KARO, Ofer

Inventor： KOSMIN, Gerald, Emmanuel

IPC: A63B51/02

CPC classification number: D07B1/162 ,  A63B51/02 ,  D07B2201/2055 ,  D07B2201/2087 ,  D07B2201/209 ,  D07B2801/12

Abstract: A composite string useful for stringing sports rackets such as tennis rackets comprises an inner core (1) of plastics material, preferably polyethylene, a sleeve (2) composed of a multiplicity of small diameter filaments peripheral to the core (1), the filaments preferably being made of a metal alloy such as stainless steel, and an outer jacket (3) of plastics material, the latter having a higher durometer than the core material. Advantageously the filaments of the sleeve (2) are braided around the core (1) and may be partially or completely embedded in the core (1) or in the jacket (3).

Abstract translation: 用于穿线运动球拍如网球拍的复合线包括塑料材料的内芯（1），优选聚乙烯，由芯（1）周围的多个小直径细丝构成的套筒（2），优选地 由诸如不锈钢的金属合金制成，并且具有塑料材料的外护套（3），后者具有比芯材料更高的硬度。 有利地，套筒（2）的细丝围绕芯部（1）编织，并且可以部分或完全地嵌入在芯部（1）中或夹套（3）中。