公开(公告)号：WO2022254227A1

公开(公告)日：2022-12-08

申请号：PCT/GB2022/051413

申请日：2022-06-06

申请人： KYMAB LIMITED

发明人： NEWTON, Anthea ,  PALU, Cintia Cristina ,  QUARATINO, Sonia ,  SAINSON, Richard Charles Alfred ,  DEANTONIO, Cecilia ,  WAKE, Matthew Stephen

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76

摘要： This invention relates to compositions and methods for the treatment of cancer, in particular difficult-to-treat cancers. More specifically, the present invention relates to compositions and methods for the treatment of PD-L1 negative or PD-L1 low expressing cancers using a modulator of ICOS, such as an anti-ICOS antibody, either alone or in combination with other agents, such as an anti-PD-L1 antibody.

公开(公告)号：WO2022207846A1

公开(公告)日：2022-10-06

申请号：PCT/EP2022/058669

申请日：2022-03-31

申请人： CAMBRIDGE ENTERPRISE LIMITED ,  KYMAB LIMITED

发明人： O’RAHILLY, Stephen ,  COLL, Anthony Patrick ,  CIMINO, Irene ,  LEE, E-Chiang ,  LIU, Hui ,  CARPENTER, Adam

IPC分类号： C07K16/28 ,  A61P43/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/76 ,  C07K2317/92

摘要： This invention relates to antibodies that bind to and inhibit the activity of glial cell-derived neurotrophic factor family receptor alpha like (GFRAL) protein. The invention also relates to the GDF15-GFRAL signalling pathway as a therapeutic target for states of cachexia and conditions involving reduction in food intake and reduction in muscle and fat mass.

公开(公告)号：WO2021229032A1

公开(公告)日：2021-11-18

申请号：PCT/EP2021/062778

申请日：2021-05-13

申请人： KYMAB LIMITED

发明人： SAINSON, Richard, Charles, Alfred ,  DEANTONIO, Cecilia ,  HSU, Chih-Hung ,  LU, Li-Chun ,  SHERRY, Lorcan, Adrian

IPC分类号： G01N33/574 ,  G01N33/50

摘要： Biomarkers for prognosis of tumours, in hepatocellular carcinoma and other cancers. Measurement of biomarkers for prescription of anticancer immunotherapy targeted against ICOS+ regulatory T cells (TReg), e.g., selecting patients for treatment with an anti-ICOS antibody. Biomarkers comprising: (i) ratio of the number of ICOS FOXP3 double positive cells within a defined radius of influence around ICOS single positive cells to the total number of ICOS single positive cells, (ii) mean distance between each ICOS positive FOXP3 negative cell and its nearest ICOS FOXP3 double positive cell, (iii) proportion of FOXP3 positive cells which are ICOS positive, and (iv) density of ICOS positive cells.

公开(公告)号：WO2020128467A2

公开(公告)日：2020-06-25

申请号：PCT/GB2019/053607

申请日：2019-12-18

申请人： KYMAB LIMITED

发明人： BRADLEY, Allan ,  LIANG, Qi ,  LEE, E-Chiang ,  LIOU, Li-Ying ,  HUANG, Yu-Hui ,  CHEN, Yen-Ju ,  CHEN, Li-Tzu

IPC分类号： A61P3/06

摘要： The invention relates to Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) antagonists, such as antibodies and fragments, as well as methods, uses and combinations.

公开(公告)号：WO2018234793A3

公开(公告)日：2018-12-27

申请号：PCT/GB2018/051714

申请日：2018-06-20

申请人： KYMAB LIMITED

发明人： CARVALHO, Joana de Abreu ,  KIMBER, Rachael Jane ,  CAMPBELL, Jamie Ian ,  SANDY, Nikole ,  VAN KRINKS, Cassandra ,  ARKINSTALL, Stephen John ,  GERMASHEWSKI, Volker ,  KIRBY, Ian ,  KOSMAC, Miha ,  GALLAGHER, Thomas ,  MCCOURT, Matthew John ,  SAINSON, Richard Charles Alfred ,  ALI, Mohammed Hanif ,  LEE, E-Chiang ,  GILLIES, Stephen Douglas

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K39/395

摘要： The present invention relates to antibodies specific for one or more antigens, such as PD-L1, TIGIT and ICOS, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

公开(公告)号：WO2018234793A2

公开(公告)日：2018-12-27

申请号：PCT/GB2018/051714

申请日：2018-06-20

申请人： KYMAB LIMITED

发明人： CARVALHO, Joana de Abreu ,  KIMBER, Rachael Jane ,  CAMPBELL, Jamie Ian ,  SANDY, Nikole ,  VAN KRINKS, Cassandra ,  ARKINSTALL, Stephen John ,  GERMASHEWSKI, Volker ,  KIRBY, Ian ,  KOSMAC, Miha ,  GALLAGHER, Thomas ,  MCCOURT, Matthew John ,  SAINSON, Richard Charles Alfred ,  ALI, Mohammed Hanif ,  LEE, E-Chiang ,  GILLIES, Stephen Douglas

摘要： The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

公开(公告)号：WO2018029474A2

公开(公告)日：2018-02-15

申请号：PCT/GB2017/052352

申请日：2017-08-09

申请人： KYMAB LIMITED

发明人： SAINSON, Richard Charles Alfred ,  ARKINSTALL, Stephen John ,  CAMPBELL, Jamie Iain ,  ALI, Mohammed Hanif ,  LEE, E-Chiang ,  MCCOURT, Matthew John ,  SANDY, Nikole ,  VAN KRINKS, Cassandra ,  GERMASCHEWSKI, Volker ,  KIRBY, Ian ,  KOSMAC, Miha ,  GALLAGHER, Thomas ,  DEANTONIO, Cecilia ,  GILLIES, Stephen Douglas

IPC分类号： C07K16/28

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/90 ,  C07K2317/92

摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti- ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

摘要翻译： 结合ICOS的抗体（诱导性T细胞共刺激剂）。 抗ICOS抗体用于调节调节性T细胞与效应T细胞之间比率的治疗用途，用于刺激患者的免疫系统，包括用于治疗癌症。 使用转基因敲除小鼠产生抗ICOS抗体的方法，包括物种交叉反应抗体。

公开(公告)号：WO2018011573A1

公开(公告)日：2018-01-18

申请号：PCT/GB2017/052046

申请日：2017-07-12

申请人： KYMAB LIMITED

发明人： WILLIAMS, Robert ,  LEE, E-Chiang ,  BRADLEY, Allan

IPC分类号： A01K67/027 ,  C07K14/705 ,  C07K16/46

摘要： The invention relates inter alia to antigen binding ligands, wherein each ligand comprises a polypeptide comprising a T-cell receptor (TCR) variable domain and an antibody constant domain, non-human vertebrate comprising in its germline a locus for producing a plurality of such antigen binding ligands and cells (eg, B-cells) expressing such ligands.

摘要翻译： 本发明尤其涉及抗原结合配体，其中每个配体包含含有T细胞受体（TCR）可变结构域和抗体恒定结构域的多肽，非人类脊椎动物在其种系中包含 用于产生多个此类抗原结合配体的基因座和表达此类配体的细胞（例如B细胞）。

公开(公告)号：WO2016139482A1

公开(公告)日：2016-09-09

申请号：PCT/GB2016/050565

申请日：2016-03-03

申请人： KYMAB LIMITED

发明人： BLAND-WARD, Philip ,  KOSMAC, Miha ,  HOLMES, Steve ,  KIRBY, Ian ,  CAMPBELL, Jamie ,  KEEN, Leslie Susan ,  TKACHEV, Victor

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2875 ,  A61K31/365 ,  A61K31/436 ,  A61K31/519 ,  A61K31/573 ,  A61K31/675 ,  A61K38/13 ,  A61K38/1793 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  C07K2319/32 ,  A61K2300/00

摘要： The present invention relates to anti-human OX40L antibodies, new medical uses methods.

摘要翻译： 本发明涉及抗人OX40L抗体，新的医疗用途方法。

公开(公告)号：WO2016023916A1

公开(公告)日：2016-02-18

申请号：PCT/EP2015/068491

申请日：2015-08-11

申请人： KYMAB LIMITED

发明人： CLUBE, Jasper

IPC分类号： C07K16/40 ,  C07K16/18 ,  C07K16/28

CPC分类号： C07K16/248 ,  C07K16/22 ,  C07K16/247 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/40

摘要： The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.

摘要翻译： 本发明涉及人类靶标（TOI），抗-TOI配体，试剂盒组合物和方法。