公开(公告)号：WO2018138090A1

公开(公告)日：2018-08-02

申请号：PCT/EP2018/051590

申请日：2018-01-23

Applicant: UNIVERSITÀ DEGLI STUDI DI GENOVA ,  L-NUTRA INC.

Inventor： NENCIONI, Alessio ,  CAFFA, Irene ,  BECHERINI, Pamela ,  LONGO, Valter

IPC: A23L33/00 ,  A23L33/20

Abstract: Diet composition for use in the prevention and/or the treatment of endometrial hyperplasia in a human subject comprising a) a fasting mimicking diet component to be administered for a first period of time and providing less than 50% of the normal caloric intake of the subject with both protein restriction and sugar restriction; and b) a re-feeding diet component to be administered for a second time period, which provides 60-100% of the normal caloric intake of the subject, wherein the fasting mimicking diet component and the re-feeding diet component are administered over multiple cycles.

公开(公告)号：WO2015144934A1

公开(公告)日：2015-10-01

申请号：PCT/EP2015/056918

申请日：2015-03-30

Applicant: UNIVERSITÀ DEGLI STUDI DI GENOVA ,  L-NUTRA INC.

Inventor： BALLESTRERO, Alberto ,  CAFFA, Irene ,  LONGO, Valter ,  NENCIONI, Alessio ,  ODETTI, Patrizio ,  PATRONE, Franco

IPC: A61K31/403 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/5365 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00

CPC classification number: A61K31/517 ,  A61K31/403 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/5365

Abstract: A tyrosine kinase inhibitor (TKI) for use in a method for the treatment of cancer in a patient, wherein the method comprises subjecting the patient to reduced caloric intake, i.e a daily caloric intake reduced by 10-100%, including starvation, for a period of 24-190 hours and administering the tyrosine kinase inhibitorto the patient during such period; the tyrosine kinase inhibitor is preferably selected among Lapatinib, Crizotinib, Gefitinib, Erlotinib, Afatinib and Regorafenib.

Abstract translation: 一种用于治疗患者癌症的方法的酪氨酸激酶抑制剂（TKI），其中所述方法包括使患者降低热量摄入，即每日热量摄入减少10-100％，包括饥饿，对于 期间24〜90小时，并在此期间向患者施用酪氨酸激酶抑制剂; 酪氨酸激酶抑制剂优选选自拉帕替尼，格列齐特，吉非替尼，埃罗替尼，阿拉美文和罗卡非尼。

公开(公告)号：WO2022012845A1

公开(公告)日：2022-01-20

申请号：PCT/EP2021/066377

申请日：2021-06-17

Applicant: L-NUTRA INC. ,  LA BARBERA, Daniele ,  MANIACI, Giuseppe ,  MIRISOLA, Mario Giuseppe

Inventor： LONGO, Valter

IPC: A23L33/00 ,  A61P25/24

Abstract: A diet composition for use in the treatment of depression in a human subject, the diet composition comprising a) a fasting mimicking diet (FMD) component to be administered for a first time period, which proves less than 50% of the normal calorie intake of the subject with both protein restriction and sugar restriction; and b) a re-feeding diet component to be administered for a second time period, which provides 60-100% of the normal calorie intake of the subject; wherein the fasting mimicking diet component and the re-feeding diet component are administered for multiple cycles, and wherein the subject undergoes a psychotherapeutic treatment for the whole duration of the multiple cycles; the first time period is preferably from 2 days to 10 days, convenienty 5 days; the second time period is preferably from 7 to 85 days, conveniently 25-26 days and the multiple cycles preferably comprise an administration once a month for at least 2 months.

公开(公告)号：WO2021257465A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/037251

申请日：2021-06-14

Applicant: L-NUTRA, INC.

Inventor： SCHIRANO, Fabrizio

IPC: A23L2/52 ,  A61K31/47 ,  A61K31/19 ,  A23F3/16 ,  A23F5/24 ,  A23L2/39 ,  A23L2/66 ,  A23L25/20 ,  A23L33/115 ,  A23L33/125 ,  A23L33/175 ,  A23L33/185 ,  A23L33/21 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00

Abstract: A fasting bar to be used for an intermittent fasting-mimicking meal includes any combination of macadamia nuts; honey; pecans; almonds; almond butter; coconut; inulin; flax seeds; coconut oil; cocoa derivatives; and coconut flour.

公开(公告)号：WO2017140641A1

公开(公告)日：2017-08-24

申请号：PCT/EP2017/053209

申请日：2017-02-14

Applicant: UNIVERSITÀ DEGLI STUDI DI GENOVA ,  L-NUTRA INC.

Inventor： NENCIONI, Alessio ,  BALLESTRERO, Alberto ,  ODETTI, Patrizio ,  MONACELLI, Fiammetta ,  CAFFA, Irene ,  LONGO, Valter

IPC: A61K31/138 ,  A61K31/337 ,  A61K31/565 ,  A61K31/704 ,  A61K45/06 ,  A61P35/00 ,  A61P43/00

CPC classification number: A61K45/06 ,  A61K31/138 ,  A61K31/337 ,  A61K31/565 ,  A61K31/704

Abstract: A compound having antiestrogenic activity is used in a method for the treatment of BC or other estrogen-responsive tumors in a human patient, wherein the method comprises subjecting the patient to a fasting mimicking diet for a period of 24- 190 hours while the patient is being treated with the compound having antiestrogenic activity, which can be a selective estrogen receptor modulator (SERM), a selective estrogen receptor downregulator (SERD) or an aromatase inhibitor (AI).

Abstract translation: 具有抗雌激素活性的化合物用于治疗人类患者的BC或其他雌激素 - 反应性肿瘤的方法中，其中该方法包括使患者禁食模拟饮食持续一段时间 （SERM），选择性雌激素受体下调剂（SERD）或芳香化酶抑制剂（AI）治疗患有抗雌激素活性的化合物治疗患者24至190小时。